LsIA [R10F] (P08946) Protein Card

General Information
Name LsIA [R10F] (named by ConoServer)
Alternative name(s) R10F-LsIA
Organism synthetic construct
Protein Type Synthetic
Parent LsIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
SGCCSNPACDVNNPNIC(nh2)
Modified residues
positionsymbolname
18nh2C-term amidation
Sequence evidence protein level
Average Mass 1705.86
Monoisotopic Mass 1704.61
Isoelectric Point 2.19
Extinction Coefficient [280nm] 500.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β4H. sapiens0.44 uM+/-0.1330 uM nicotineAbraham,N. et al. (2017)
α7H. sapiens0.41 uM+/-0.4130 uM cholineAbraham,N. et al. (2017)

Ki: Nicotinic acetylcholine receptors

TargetOrganismKiCompetitorAgonistRef
AChBPA. californica2.20 nM+/-0.05epibatidine (1 nM)Abraham,N. et al. (2017)
L. stagnalis0.11 uM+/-0.02epibatidine (1 nM)Abraham,N. et al. (2017)
0.8 uM+/-0.26epibatidine (1 nM)Abraham,N. et al. (2017)

References
Abraham,N., Healy,M., Ragnarsson,L., Brust,A., Alewood,P.F. and Lewis,R.J. (2017) Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor. Sci Rep 7:45466

Internal links
Nucleic acids
Structure

External links

Tools