LsIA [N12L] (P08949) Protein Card

General Information
Name LsIA [N12L] (named by ConoServer)
Alternative name(s) N12L-LsIA
Organism synthetic construct
Protein Type Synthetic
Parent LsIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
SGCCSNPACRVLNPNIC(nh2)
Modified residues
positionsymbolname
18nh2C-term amidation
Sequence evidence protein level
Average Mass 1746.02
Monoisotopic Mass 1744.73
Isoelectric Point 10.94
Extinction Coefficient [280nm] 500.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β4H. sapiens0.63 uM+/-0.1630 uM nicotineAbraham,N. et al. (2017)
α7H. sapiens25.7 uM+/-12.330 uM cholineAbraham,N. et al. (2017)

Ki: Nicotinic acetylcholine receptors

TargetOrganismKiCompetitorAgonistRef
AChBPA. californica61 nM+/-7epibatidine (1 nM)Abraham,N. et al. (2017)
L. stagnalis>10 uMepibatidine (1 nM)Abraham,N. et al. (2017)

References
Abraham,N., Healy,M., Ragnarsson,L., Brust,A., Alewood,P.F. and Lewis,R.J. (2017) Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor. Sci Rep 7:45466

Internal links
Nucleic acids
Structure

External links

Tools