LsIA [R10F,N12L] (P08950) Protein Card

General Information

Name	LsIA [R10F,N12L] (named by ConoServer)
Alternative name(s)	[R10F][N12L]-LsIA
Organism	synthetic construct
Protein Type	Synthetic
Parent	LsIA

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	I
Pharmacological family	alpha conotoxin

Sequence

SGCCSNPACFVLNPNIC(nh2)
Modified residues	position symbol name 18 nh2 C-term amidation
Sequence evidence	protein level
Average Mass	1737.01
Monoisotopic Mass	1735.69
Isoelectric Point	7.00
Extinction Coefficient [280nm]	500.00

Activity

IC50: Nicotinic acetylcholine receptors

Target	Organism	IC50		Agonist	Ref
α3β4	H. sapiens	0.41 uM	+/-0.02	30 uM nicotine	Abraham,N. et al. (2017)
α7	H. sapiens	>100 uM		30 uM choline	Abraham,N. et al. (2017)

References

Abraham,N., Healy,M., Ragnarsson,L., Brust,A., Alewood,P.F. and Lewis,R.J. (2017) Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor. Sci Rep 7:45466

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Thursday 28 September 2023