TxIA[ribbon] (P08959) Protein Card

General Information
Name TxIA[ribbon] (named by ConoServer)
Alternative name(s) rTxIA
Organism synthetic construct
Protein Type Synthetic
Parent TxIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSRPPCIANNPDLC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Sequence evidence protein level
Average Mass 1657.91
Monoisotopic Mass 1656.66
Isoelectric Point 7.00
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus928 nM[810-1064]ACh (100 uM)El Hamdaoui,Y. et al. (2019)
430 nMACh (100 uM)Wu,Y. et al. (2014)
α7R. norvegicus~200 nMnicotine(100 uM)El Hamdaoui,Y. et al. (2019)

References
El Hamdaoui,Y., Wu,X., Clark,R.J., Giribaldi,J., Anangi,R., Craik,D.J., King,G.F., Dutertre,S., Kaas,Q., Herzig,V. and Nicke,A. (2019) Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation - Suggestion of a Binding Mode at the α7 nAChR. Front Pharmacol 10:577
Wu,Y., Wu,X., Yu,J., Zhu,X., Zhangsun,D. and Luo,S. (2014) Influence of disulfide connectivity on structure and bioactivity of α-conotoxin TxIA Molecules 19:966-979

Internal links
Nucleic acids
Structure

External links
Ncbi 6OTA

Tools