TxIA[ribbon] deamidated (P08960) Protein Card

General Information
Name TxIA[ribbon] deamidated (named by ConoServer)
Alternative name(s) Recombinant TxIA
Organism synthetic construct
Protein Type Synthetic
Parent TxIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSRPPCIANNPDLC
Sequence evidence protein level
Average Mass 1658.89
Monoisotopic Mass 1657.65
Isoelectric Point 7.00
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus470 nM[432-512]Ach (100 uM)El Hamdaoui,Y. et al. (2019)
α7R. norvegicus~200 nMnicotine(100 uM)El Hamdaoui,Y. et al. (2019)

References
El Hamdaoui,Y., Wu,X., Clark,R.J., Giribaldi,J., Anangi,R., Craik,D.J., King,G.F., Dutertre,S., Kaas,Q., Herzig,V. and Nicke,A. (2019) Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation - Suggestion of a Binding Mode at the α7 nAChR. Front Pharmacol 10:577

Internal links
Nucleic acids
Structure

External links

Tools