TxIA[R5N,ribbon] deamidated (P08961) Protein Card

General Information
Name TxIA[R5N,ribbon] deamidated (named by ConoServer)
Alternative name(s) Recombinant [R5N]TxIA
Organism synthetic construct
Protein Type Synthetic
Parent TxIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSNPPCIANNPDLC
Sequence evidence protein level
Average Mass 1616.81
Monoisotopic Mass 1615.59
Isoelectric Point 3.17
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus1834 nM[1704-1974]Ach (100 uM)El Hamdaoui,Y. et al. (2019)

References
El Hamdaoui,Y., Wu,X., Clark,R.J., Giribaldi,J., Anangi,R., Craik,D.J., King,G.F., Dutertre,S., Kaas,Q., Herzig,V. and Nicke,A. (2019) Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation - Suggestion of a Binding Mode at the α7 nAChR. Front Pharmacol 10:577

Internal links
Nucleic acids
Structure

External links

Tools