PeIA[S9H,V10L,N11(Asu)] (P08985) Protein Card

General Information
Name PeIA[S9H,V10L,N11(Asu)] (named by ConoServer)
Alternative name(s) PeIA-5587
Organism synthetic construct
Protein Type Synthetic
Parent PeIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSHPACHL(Asu)HPELC(nh2)
Modified residues
positionsymbolname
11Asualpha-aminosuberic acid
17nh2C-term amidation
Sequence evidence Unknown
Average Mass 1809.07
Monoisotopic Mass 1807.73
Isoelectric Point 7.10
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus1.28 nM[1.06-1.54]Ach (100 uM)Hone,A.J. et al. (2019)
α6/α3β2β3R. norvegicus50.3 nM[40.4-62.7]Ach (100 uM)Hone,A.J. et al. (2019)

References
Hone,A.J., Fisher,F., Christensen,S., Gajewiak,J., Larkin,D., Whiteaker,P. and McIntosh,J.M. (2019) PeIA-5466: A Novel Peptide Antagonist Containing Non-natural Amino Acids That Selectively Targets α3β2 Nicotinic Acetylcholine Receptors J. Med. Chem. 62:6262-6275

Internal links
Nucleic acids
Structure

External links

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