Conomarphin Eu2 (P08992) Protein Card

General Information
Name Conomarphin Eu2
Alternative name(s) Conomarphin Eb2
Organism Conus eburneus
Organism diet generalist
Protein Type Wild type
Notes Mendoza et al.,2019 reported that treatment of Conomarphin Eb2 in P. padulosa caused sluggishness (>0.5 nmol), with minimal exposure of foot and cephalic tentacles (>5 nmol), while elicit no effects on C.auratus and mice.

Classification
Conopeptide class conomarphin
Gene superfamily
Pharmacological family

Sequence
GWVYHANP(Gla)ANSWWT
Modified residues
positionsymbolname
9GlaGamma carboxylic glutamic acid
Sequence evidence protein level
Average Mass 1861.95
Monoisotopic Mass 1860.78
Isoelectric Point 6.60
Extinction Coefficient [280nm] 17990.00

References
Mendoza,C.B., Masacupan,D.J.M., Batoctoy,D.C.R., Yu,E.T., Lluisma,A.O. and Salvador-Reyes,L.A. (2019) Conomarphins cause paralysis in mollusk: Critical and tunable structural elements for bioactivity. J. Pept. Sci. 25
Itang,C.E.M.M., Gaza,J.T., Masacupan,D.J.M., Batoctoy,D.C.R., Chen,Y.J., Nellas,R.B. and Yu,E.T. (2020) Identification of Conomarphin Variants in the Conus eburneus Venom and the Effect of Sequence and PTM Variations on Conomarphin Conformations. Mar Drugs 18

Internal links
Nucleic acids
Structure

External links

Tools