SII precursor (P00009) Protein Card

General Information
Name SII precursor
Organism Conus striatus (Striated cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Precursor

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Pharmacological family

Sequence
MGMRMMFTVFLLVVLATTVVS
FPSDRASDGRDDEAKDERSD
MHESDRNGR
GCCCNPACGPNYGCGTSCS
RTL
Sequence region
[1-21]signal sequence
[51-69]mature peptideSII

References
Santos,A.D., McIntosh,J.M., Hillyard,D.R., Cruz,L.J. and Olivera,B.M. (2004) The A-superfamily of conotoxins: structural and functional divergence J. Biol. Chem. 279:17596-17606
Wang,C.Z., Jiang,H., Ou,Z.L., Chen,J.S. and Chi,C.W. (2003) cDNA cloning of two A-superfamily conotoxins from Conus striatus Toxicon 42:613-619
Ramilo,C., Zafaralla,G.C., Nadasdi,L., Hammerland,L.G., Yoshikami,D., Gray,W.R., Kristipati,R., Ramachandran,J., Miljanich,G.P., Olivera,B.M. and Cruz,L.J. (1992) Novel alpha- and omega-conotoxins from Conus striatus venom Biochemistry 31:9919-9926
Bingham,J.P., Broxton,N.M., Livett,B.G., Down,J.G., Jones,A. and Moczydlowski,E.G. (2005) Optimizing the connectivity in disulfide-rich peptides: alpha-conotoxin SII as a case study Anal. Biochem. 338:48-61

Internal links
Nucleic acids Sequence 40 from patent US 6855805
Alpha Conotoxin Peptides
Structure

External links
UniProtKB/Swiss-Prot P28879
Ncbi P28879

Tools