SII (P00090) Protein Card

General Information
Name SII
Organism Conus striatus (Striated cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor SII precursor (9)
SII precursor (91)
SII precursor (3900)
SII precursor (3954)

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework II
Pharmacological family alpha conotoxin

Sequence
GCCCNPACGPNYGCGTSCS
Sequence evidence protein level
Average Mass 1790.95
Monoisotopic Mass 1789.51
Isoelectric Point 8.09
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50CompetitorRef
α1β1δεR. norvegicus(mouse epsilon subunit)120 nM+/-17Wilhelm,P. et al. (2022)
α1β1γδR. norvegicus370 nM+/-62Wilhelm,P. et al. (2022)
T. californica8uMI125-BgtxRamilo,C. et al. (1992)

Synthetic variants
Ile-SII(3-14)-NH2ICCNPACGPNYGC(nh2)
Ile-SII(3-14)-OHICCNPACGPNYGC

References
Ramilo,C., Zafaralla,G.C., Nadasdi,L., Hammerland,L.G., Yoshikami,D., Gray,W.R., Kristipati,R., Ramachandran,J., Miljanich,G.P., Olivera,B.M. and Cruz,L.J. (1992) Novel alpha- and omega-conotoxins from Conus striatus venom Biochemistry 31:9919-9926
Wilhelm,P., Luna-Ramirez,K., Chin,Y.K., Dekan,Z., Abraham,N., Tae,H.S., Chow,C.Y., Eagles,D.A., King,G.F., Lewis,R.J., Adams,D.J., and Alewood,P.F. (2022) Cysteine-Rich α-Conotoxin SII Displays Novel Interactions at the Muscle Nicotinic Acetylcholine Receptor. ACS Chemical Neurosci 13:1245-1250

Internal links
Protein Precursor SII precursor (9)
SII precursor (91)
SII precursor (3900)
SII precursor (3954)
Nucleic acids
Structure NMR structure of alpha conotoxin SII

External links
Ncbi AAB23762

Tools