AtVIA (P09000) Protein Card

General Information

Name	AtVIA
Organism	Conus ateralbus
Organism region	Western Atlantic and Caribbean
Organism diet	piscivorous
Protein Type	Wild type
Notes	Neves et al.,2019 reported that AtVIA showed excitatory activity on a majority(>80%) of mouse lumbar dorsal root ganglion neurons.

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	VI/VII
Pharmacological family

Sequence

ZCGADGQFCFLPGLGLNCCSGLCLIVCVPT

Modified residues

position	symbol	name
1	Z	Pyroglutamic acid

Sequence evidence

protein level

Average Mass

Monoisotopic Mass

Isoelectric Point

1.31

Extinction Coefficient [280nm]

750.00

Synthetic variants

AtVIA[I25L,V28L,T30S]

ZCGADGQFCFLPGLGLNCCSGLCLLVCLPS

References

Neves,J.L.B., Imperial,J.S., Morgenstern,D., Ueberheide,B., Gajewiak,J., Antunes,A., Robinson,S.D., Espino,S., Watkins,M., Vasconcelos,V. and Olivera,B.M. (2019) Characterization of the First Conotoxin from Conus ateralbus, a Vermivorous Cone Snail from the Cabo Verde Archipelago Mar Drugs 17:432

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Sunday 2 April 2023