EI[S13A] (P09030) Protein Card

General Information

Name	EI[S13A]
Organism	synthetic construct
Protein Type	Synthetic
Parent	EI

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	I
Pharmacological family	alpha conotoxin

Sequence

RDOCCYHPTCNMANPQIC(nh2)

Modified residues

position	symbol	name
3	O	4-Hydroxyproline
19	nh2	C-term amidation

Sequence evidence

protein level

Average Mass

2077.36

Monoisotopic Mass

2075.79

Isoelectric Point

7.98

Extinction Coefficient [280nm]

1490.00

Activity

IC50: Nicotinic acetylcholine receptors

Target	Organism	IC50		n_hill	Agonist	Ref
α1β1δε	M. musculus	34.6 nM	[28.2-42.4]	1.2	ACh(10 uM)	Ning,J. et al. (2019)
α3β2	R. norvegicus	>10 uM			ACh(100 uM)	Ning,J. et al. (2019)
α3β4	R. norvegicus	>10 uM			ACh(100 uM)	Ning,J. et al. (2019)

References

Ning,J., Ren,J., Xiong,Y., Wu,Y., Zhangsun,M., Zhangsun,D., Zhu,X. and Luo,S. (2019) Identification of Crucial Residues in α-Conotoxin EI Inhibiting Muscle Nicotinic Acetylcholine Receptor Toxins (Basel) 11:603

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Saturday 30 September 2023