EI[N14A] (P09031) Protein Card

General Information
Name EI[N14A]
Organism synthetic construct
Protein Type Synthetic
Parent EI

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
RDOCCYHPTCNMSAPQIC(nh2)
Modified residues
positionsymbolname
3O4-Hydroxyproline
19nh2C-term amidation
Sequence evidence protein level
Average Mass 2050.34
Monoisotopic Mass 2048.78
Isoelectric Point 7.98
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α1β1δεM. musculus349 nM[315-386]1.3ACh(10 uM)Ning,J. et al. (2019)
α3β2R. norvegicus>10 uMACh(100 uM)Ning,J. et al. (2019)
α3β4R. norvegicus>10 uMACh(100 uM)Ning,J. et al. (2019)

References
Ning,J., Ren,J., Xiong,Y., Wu,Y., Zhangsun,M., Zhangsun,D., Zhu,X. and Luo,S. (2019) Identification of Crucial Residues in α-Conotoxin EI Inhibiting Muscle Nicotinic Acetylcholine Receptor Toxins (Basel) 11:603

Internal links
Nucleic acids
Structure

External links

Tools