Pl1.1 (P09048) Protein Card

General Information
Name Pl1.1 (named by ConoServer)
Alternative name(s) Pl168
Organism Conus planorbis
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Notes Wilson et al.,2020 reported that Pl1.1 (30 μM) had no effect on α7 nAChR, nicotine-induced α3 nAChR, L-type (CaV1) voltage-gated Ca2+ channel and voltage-gated Na+ channel responses, but only a small (18%) inhibition of N-type (CaV2.2) voltage-gated Ca2+ channel responses.

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family

Sequence
GIRGNCCMFHTCPIDYSRFYCP
Sequence evidence nucleic acid level
Average Mass 2579.98
Monoisotopic Mass 2578.04
Isoelectric Point 10.99
Extinction Coefficient [280nm] 2980.00

Activity

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationAgonistRef
α3β2R. norvegicus0100 μMACh (100 μM)Wilson,D.T. et al. (2020)
α4β2R. norvegicus0100 μMACh (100 μM) Wilson,D.T. et al. (2020)
α7R. norvegicus0100 μMnicotine (100 μM) Wilson,D.T. et al. (2020)

References
Wilson,D.T., Bansal,P.S., Carter,D.A., Vetter,I., Nicke,A., Dutertre,S. and Daly,N.L. (2020) Characterisation of a Novel A-Superfamily Conotoxin Biomedicines 8:128

Internal links
Nucleic acids
Structure

External links

Tools