TxIA[beads] (P09049) Protein Card

General Information

Name	TxIA[beads]
Organism	synthetic construct
Protein Type	Synthetic
Parent	TxIA

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	I
Pharmacological family	alpha conotoxin

Sequence

GCCSRPPCIANNPDLC(nh2)
Modified residues	position symbol name 17 nh2 C-term amidation
Sequence evidence	protein level
Average Mass	1657.91
Monoisotopic Mass	1656.66
Isoelectric Point	7.00
Extinction Coefficient [280nm]	NA

Activity

Percentage inhibition: Nicotinic acetylcholine receptors

Target	Organism	% inhibition		Concentration	Agonist	Ref
α3β2	R. norvegicus	20		10 uM	Ach (100 uM)	Wu,Y. et al. (2014)

References

Wu,Y., Wu,X., Yu,J., Zhu,X., Zhangsun,D. and Luo,S. (2014) Influence of disulfide connectivity on structure and bioactivity of α-conotoxin TxIA Molecules 19:966-979

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 21 March 2023