TxIB[insC_M] (P09072) Protein Card

General Information
Name TxIB[insC_M] (named by ConoServer)
Alternative name(s) rTxIB
Organism synthetic construct
Protein Type Synthetic
Parent TxIB

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSDPPCRNKHPDLCM
Sequence evidence protein level
Average Mass 1872.14
Monoisotopic Mass 1870.70
Isoelectric Point 8.31
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α1β1δεM. musculus>10uMACh (10uM)Yu,J. et al. (2018)
α2β2R. norvegicus>10uMACh (100uM)Yu,J. et al. (2018)
α3β2R. norvegicus>10uMACh (100uM)Yu,J. et al. (2018)
α3β4R. norvegicus>10uMACh (100uM)Yu,J. et al. (2018)
α4β2R. norvegicus>10uMACh (100uM)Yu,J. et al. (2018)
α4β4R. norvegicus>10uMACh (100uM)Yu,J. et al. (2018)
α6/α3β2β3R. norvegicus89.5 nM[73-109.8]0.73ACh (100uM)Yu,J. et al. (2018)
α6/α3β4R. norvegicus>10uMACh (100uM)Yu,J. et al. (2018)
α7R. norvegicus>10uMACh (200uM)Yu,J. et al. (2018)
α9α10R. norvegicus>10uMACh (10uM)Yu,J. et al. (2018)

References
Yu,J., Zhu,X., Yang,Y., Luo,S. and Zhangsun,D. (2018) Expression in Escherichia coli of fusion protein comprising α-conotoxin TxIB and preservation of selectivity to nicotinic acetylcholine receptors in the purified product Chem Biol Drug Des 91:349-358

Internal links
Nucleic acids
Structure

External links

Tools