Vc1.1[N9R] acetylated (P09080) Protein Card

General Information
Name Vc1.1[N9R] acetylated (named by ConoServer)
Alternative name(s) Ac-Vc1.1[N9R]
Organism synthetic construct
Protein Type Synthetic
Parent Vc1.1

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
(Ac)GCCSDPRCRYDHPEIC(nh2)
Modified residues
positionsymbolname
1AcN-Acetate (on N-terminus)
18nh2C-term amidation
Average Mass 1891.09
Monoisotopic Mass 1889.71
Isoelectric Point NA
Extinction Coefficient [280nm] NA

Activity

IC50: Voltage-Gated Calcium Channels

TargetOrganismIC50AgonistRef
Cav2.2H. sapiens(GABABR-coupled CaV2.2)18.9 nM[7.9-45.5]Cai,F. et al. (2018)

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α9α10R. norvegicus2416 nM[1462-3993]ACh(6 μM)Cai,F. et al. (2018)

References
Cai,F., Xu,N., Liu,Z., Ding,R., Yu,S., Dong,M., Wang,S., Shen,J., Tae,H.S., Adams,D.J., Zhang,X. and Dai,Q. (2018) Targeting of N-Type Calcium Channels via GABAB-Receptor Activation by α-Conotoxin Vc1.1 Variants Displaying Improved Analgesic Activity J. Med. Chem. 61:10198-10205

Internal links
Nucleic acids
Structure

External links

Tools