GI[N4A] (P09095) Protein Card

General Information
Name GI[N4A]
Organism synthetic construct
Protein Type Synthetic
Parent GI

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
ECCAPACGRHYSC(nh2)
Modified residues
positionsymbolname
14nh2C-term amidation
Average Mass 1394.57
Monoisotopic Mass 1393.48
Isoelectric Point 8.31
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α1β1δεM. musculus4.66 nM[4.19-5.18]1.49ACh (10 uM)Ning,J. et al. (2018)

References
Ning,J., Li,R., Ren,J., Zhangsun,D., Zhu,X., Wu,Y. and Luo,S. (2018) Alanine-Scanning Mutagenesis of α-Conotoxin GI Reveals the Residues Crucial for Activity at the Muscle Acetylcholine Receptor Mar Drugs 16:507

Internal links
Nucleic acids
Structure

External links

Tools