GI[G8A] (P09097) Protein Card

General Information
Name GI[G8A]
Organism synthetic construct
Protein Type Synthetic
Parent GI

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
ECCNPACARHYSC(nh2)
Modified residues
positionsymbolname
14nh2C-term amidation
Average Mass 1451.62
Monoisotopic Mass 1450.50
Isoelectric Point 8.31
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α1β1δεM. musculus170.60 nM[134.6-216.3]0.94ACh (10 uM)Ning,J. et al. (2018)
α9α10R. norvegicus4.21 uM[3.21-5.51]1.2ACh (10 uM)Ning,J. et al. (2018)

References
Ning,J., Li,R., Ren,J., Zhangsun,D., Zhu,X., Wu,Y. and Luo,S. (2018) Alanine-Scanning Mutagenesis of α-Conotoxin GI Reveals the Residues Crucial for Activity at the Muscle Acetylcholine Receptor Mar Drugs 16:507

Internal links
Nucleic acids
Structure

External links

Tools