GIC precursor (P00097) Protein Card

General Information

Name	GIC precursor
Organism	Conus geographus (Geography cone)
Organism region	Indo-Pacific
Organism diet	piscivorous
Protein Type	Precursor

Classification

Conopeptide class	conotoxin
Gene superfamily	A superfamily
Pharmacological family

Sequence

SDGRNDAAKAFDLISSTVKK GCCSHPACAGNNQHIC GRRR
Sequence region	[21-36] mature peptide GIC

References

McIntosh,J.M., Dowell,C., Watkins,M., Garrett,J.E., Yoshikami,D. and Olivera,B.M. (2002) Alpha-conotoxin GIC from Conus geographus, a novel peptide antagonist of nicotinic acetylcholine receptors J. Biol. Chem. 277:33610-33615

Chi,S.W., Kim,D.H., Olivera,B.M., McIntosh,J.M. and Han,K.H. (2004) Solution conformation of alpha-conotoxin GIC, a novel potent antagonist of alpha3beta2 nicotinic acetylcholine receptors Biochem. J. 380:347-352

Internal links

Nucleic acids	Conus geographus alpha-conotoxin GIC precursor, gene, partial cds GIC precursor
Structure

External links

UniProtKB/Swiss-Prot	Q86RB2
Ncbi	Q86RB2, AAO33169

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 21 March 2023