RgIA [R11Nar] (P09740) Protein Card

General Information

Name	RgIA [R11Nar] (named by ConoServer)
Alternative name(s)	[Nar11]RgIA
Organism	synthetic construct
Protein Type	Synthetic
Parent	RgIA

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	I
Pharmacological family	alpha conotoxin

Sequence

GCCSDPRCRY(Nar)CR
Modified residues	position symbol name 11 Nar Norarginine
Average Mass	1556.77
Monoisotopic Mass	1555.60
Isoelectric Point	12.20
Extinction Coefficient [280nm]	1490.00

Activity

IC50: Nicotinic acetylcholine receptors

Target	Organism	IC50		Ref
α9α10	H. sapiens	213 nM	[174-261]	Huynh,P.N. et al. (2020)
	R. norvegicus	11.4	[9.4-13.9]	Huynh,P.N. et al. (2020)

References

Huynh,P.N., Harvey,P.J., Gajewiak,J., Craik,D.J. and Michael McIntosh,J. (2020) Critical residue properties for potency and selectivity of α-Conotoxin RgIA towards α9α10 nicotinic acetylcholine receptors. Biochem. Pharmacol. :114124

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Friday 1 December 2023