SxIIIC (P09774) Protein Card

General Information

Name	SxIIIC
Organism	Conus striolatus
Organism region	Indo-Pacific
Organism diet	piscivorous
Protein Type	Wild type

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	III
Pharmacological family	mu conotoxin

Sequence

RGCCNGRGGCSSRWCRDHARCC(nh2)

Modified residues

position	symbol	name
23	nh2	C-term amidation

Sequence evidence

protein level

Average Mass

2436.73

Monoisotopic Mass

2434.93

Isoelectric Point

12.67

Extinction Coefficient [280nm]

5500.00

Activity

IC50: Voltage-Gated Sodium Channels

Target	Organism	IC50		Ref
Na_v1.1	H. sapiens	132.0 nM	+/-11.6	McMahon,K.L. et al. (2020)
Na_v1.2	H. sapiens	363.8 nM	+/-53.8	McMahon,K.L. et al. (2020)
Na_v1.3	H. sapiens	89.4 nM	+/-11.1	McMahon,K.L. et al. (2020)
Na_v1.4	H. sapiens	15.1 nM	+/-10.7	McMahon,K.L. et al. (2020)
Na_v1.5	H. sapiens	>5000 nM		McMahon,K.L. et al. (2020)
Na_v1.6	H. sapiens	124.9 nM	+/-11.1	McMahon,K.L. et al. (2020)
Na_v1.7	H. sapiens	152.2 nM	+/-21.8	McMahon,K.L. et al. (2020)
Na_v1.8	H. sapiens	>5000 nM		McMahon,K.L. et al. (2020)

References

McMahon,K.L., Tran,H.N.T., Deuis,J.R., Lewis,R.J., Vetter,I. and Schroeder,C.I. (2020) Discovery, Pharmacological Characterisation and NMR Structure of the Novel µ-Conotoxin SxIIIC, a Potent and Irreversible Na_V Channel Inhibitor. Biomedicines 8

Internal links

Nucleic acids
Structure	SxIIIC

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Wednesday 29 March 2023