LvIA[E14A] (P09964) Protein Card

General Information
Name LvIA[E14A] (named by ConoServer)
Alternative name(s) [E14A]LvIA
Organism synthetic construct
Protein Type Synthetic
Parent LvIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSHPACNVDHPAIC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Average Mass 1621.83
Monoisotopic Mass 1620.60
Isoelectric Point 6.81
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillCompetitorRef
α3β2R. norvegicus29 nM[20.7-40.7]0.83Zhu,X. et al. (2020)
α3β4R. norvegicus181 nM[146-225]0.86Zhu,X. et al. (2020)
AChBPA. californica760 nM+/-80α-bungarotoxin (0.9 nM)Zhu,X. et al. (2020)

References
Zhu,X., Pan,S., Xu,M., Zhang,L., Yu,J., Yu,J., Wu,Y., Fan,Y., Li,H., Kasheverov,I.E., Kudryavtsev,D.S., Tsetlin,V.I., Xue,Y., Zhangsun,D., Wang,X. and Luo,S. (2020) High Selectivity of an α-Conotoxin LvIA Analogue for α3β2 Nicotinic Acetylcholine Receptors Is Mediated by β2 Functionally Important Residues. J Med Chem 63:13656-13668

Internal links
Nucleic acids
Structure

External links

Tools