TxID[S9A,insN_GA] cyclic (P09980) Protein Card

General Information
Name TxID[S9A,insN_GA] cyclic (named by ConoServer)
Alternative name(s) c[S9A]TxID-2
Organism synthetic construct
Protein Type Synthetic
Parent TxID[S9A]

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GAGCCSHPVCAAMSPIC
Average Mass 1584.87
Monoisotopic Mass 1583.58
Isoelectric Point 10.50
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillRef
α3β4R. norvegicus353 nM[295-423]1.2Wang,S. et al. (2021)

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationRef
α3β4R. norvegicus79.20 (75.95-82.46)1 µMWang,S. et al. (2021)

References
Wang,S., Ren,J., Li,R., Li,X., Zhangsun,D., Wu,Y. and Luo,S. (2021) Synthesis and evaluation of disulfide-rich cyclic α-conotoxin [S9A]TxID analogues as novel α3β4 nAChR antagonists. Bioorg Chem 112:104875

Internal links
Nucleic acids
Structure

External links

Tools