TxID[S9A,insN_GGAG] cyclic (P09982) Protein Card

General Information
Name TxID[S9A,insN_GGAG] cyclic (named by ConoServer)
Alternative name(s) c[S9A]TxID-4
Organism synthetic construct
Protein Type Synthetic
Parent TxID[S9A]

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GGAGGCCSHPVCAAMSPIC
Average Mass 1698.97
Monoisotopic Mass 1697.62
Isoelectric Point 10.50
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillRef
α3β4R. norvegicus205 nM[56-271]1.1Wang,S. et al. (2021)

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationRef
α3β4R. norvegicus85.74 (80.08–91.40)1 µMWang,S. et al. (2021)

References
Wang,S., Ren,J., Li,R., Li,X., Zhangsun,D., Wu,Y. and Luo,S. (2021) Synthesis and evaluation of disulfide-rich cyclic α-conotoxin [S9A]TxID analogues as novel α3β4 nAChR antagonists. Bioorg Chem 112:104875

Internal links
Nucleic acids
Structure

External links

Tools