Reference List
The references are sorted by year then first author.Each reference is followed by a 'P' link and a 'NA' link that search the corresponding protein sequences and nucleic acid sequences, respectively.
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2023 Espiritu,M.J., Taylor,J.K., Sugai,C.K., Thapa,P., Loening,N.M., Gusman,E., Baoanan,Z.G., Baumann,M.H., and Bingham,J.P. Characterization of the Native Disulfide Isomers of the Novel χ-Conotoxin PnID: Implications for Further Increasing Conotoxin Diversity. Mar Drugs (2023) 21: 61-0 [P, NA] |
| Krishnarjuna,B., Sunanda,P., Seow,J., Tae,H.-S., Robinson,S.D., Belgi, A., Robinson,A.J., Safavi-Hemami,H., Adams,D.J., Norton,R.S. Characterisation of Elevenin-Vc1 from the Venom of Conus victoriae: A Structural Analogue of α-Conotoxins. Mar drugs (2023) 21: 81-0 [P, NA] |
| Van Baelen,A.C., Iturrioz,X., Chaigneau,M., Kessler,P., Llorens-Cortes,C., Servent,D., Gilles,N., and Robin,P. Characterization of the First Animal Toxin Acting as an Antagonist on AT1 Receptor. Int J Mol Sci (2023) 24: 2330-0 [P, NA] |
| Zhu,X., Wang,S., Kaas,Q., Yu,J., Wu,Y., Harvey,P.J., Zhangsun,D., Craik,D.J., and Luo,S. Characterization, and Engineering of LvIC, an α4/4-Conotoxin That Selectively Blocks Rat α6/α3β4 Nicotinic Acetylcholine Receptors. J Med Chem (2023) 66: 2020-2031 [P, NA] |
2022 Bony,A.R., McArthur,J.R., Finol-Urdaneta,R.K., and Adams,D.J. Analgesic α-conotoxins modulate native and recombinant GIRK1/2 channels via activation of GABAB receptors and reduce neuroexcitability. Br J Pharmacol (2022) 179: 179-198 [P, NA] |
| Fu,Y., Zhang,Y., Ju,S., Ma,B., Huang,W., and Luo,S. Isolation and characterization of five novel disulfide-poor conopeptides from Conus marmoreus venom. J Venom Anim Toxins Incl Trop Dis. (2022) 28 [P, NA] |
| Hernández-Sámano,A.C., Falcón,A., Zamudio,F., Michel-Morfín,J.E., Landa-Jaime,V., López-Vera,E., Jeziorski,M.C., Aguilar,M.B. A short framework-III (mini-M-2) conotoxin from the venom of a vermivorous species, Conus archon, inhibits human neuronal nicotinic acetylcholine receptors. Peptides (2022) 153: 170785-0 [P, NA] |
| Mao,K., Li,X., Chen,Z., Dong,X., Zhangsun,D., Zhu,X., and Luo,S. α-Conotoxin TxIB Improved Behavioral Abnormality and Changed Gene Expression in Zebrafish (Danio rerio) Induced by Alcohol Withdrawal. Front Pharmacol (2022) 13: 802917-0 [P, NA] |
| Meng,G., Kuyucak,S. Computational Design of High-Affinity Blockers for Sodium Channel NaV1.2 from µ-Conotoxin KIIIA. Mar Drugs (2022) 20: 154-0 [P, NA] |
| Rodriguez-Ruiz, X.C., Aguilar, M.B., Ortíz-Arellano, M.A., Safavi-Hemami, H., and López-Vera, E. A Novel Dimeric Conotoxin, FrXXA, from the Vermivorous Cone Snail Conus fergusoni, of the Eastern Pacific, Inhibits Nicotinic Acetylcholine Receptors. Toxins (2022) 14: 510-0 [P, NA] |
| Ruelas-Callejas, A., Aguilar, M.B., Arteaga-Tlecuitl, R., Gomora, J.C., and López-Vera, E. The T-1 conotoxin µ-SrVA from the worm hunting marine snail Conus spurius preferentially blocks the human NaV1.5 channel. Peptides (2022) : 170859-0 [P, NA] |
| Saintmont,F., Cazals,G., Bich,C., and Dutertre,S. Proteomic Analysis of the Predatory Venom of Conus striatus Reveals Novel and Population-Specific κA-Conotoxin SIVC Toxins (2022) 14: 799-0 [P, NA] |
| Tran,H.N.T., McMahon,K.L., Deuis,J.R., Vetter,I., Schroeder,C.I. Structural and functional insights into the inhibition of human voltage-gated sodium channels by µ-conotoxin KIIIA disulfide isomers. J Biol Chem (2022) 298: 101728-0 [P, NA] |
| Wang,H., Li,Y., Yang, M., and Zhou,M. Synthesis and characterization of αM-conotoxin SIIID, a reversible human α7 nicotinic acetylcholine receptor antagonist. Toxicon (2022) 210: 141-147 [P, NA] |
| Wang,L., Wu,X., Zhu,X., Zhangsun,D., Wu,Y., Luo,S. A Novel α4/7-Conotoxin QuIA Selectively Inhibits α3β2 and α6/α3β4 Nicotinic Acetylcholine Receptor Subtypes with High Efficacy Mar Drugs (2022) 20: 146-0 [P, NA] |
| Wang,S., Bartels,P., Zhao,C., Yousuf,A., Liu,Z., Yu,S., Bony,A.R., Ma,X., Dai,Q., Sun,T., Liu,N., Yang,M., Yu,R., Du,W., Adams,D.J., Dai,Q. A 4/8 Subtype α-Conotoxin Vt1.27 Inhibits N-Type Calcium Channels With Potent Anti-Allodynic Effect Frontiers in Pharmacology (2022) 13 [P, NA] |
| Wilhelm,P., Luna-Ramirez,K., Chin,Y.K., Dekan,Z., Abraham,N., Tae,H.S., Chow,C.Y., Eagles,D.A., King,G.F., Lewis,R.J., Adams,D.J., and Alewood,P.F. Cysteine-Rich α-Conotoxin SII Displays Novel Interactions at the Muscle Nicotinic Acetylcholine Receptor. ACS Chemical Neurosci (2022) 13: 1245-1250 [P, NA] |
| Zheng,M., Tae,H.S., Xue,L., Jian,T., Yu,R. Mechanism of interactions between α-conotoxin RegIIA and carbohydrates at the human α3β4 nicotinic acetylcholine receptor. Mar Life Sci Technol (2022) 4: 98-105 [P, NA] |
2021 Armstrong,D.A., Jin,A.H., Braga Emidio,N., Lewis,R.J., Alewood,P.F. and Rosengren,K.J. Chemical Synthesis and NMR Solution Structure of Conotoxin GXIA from Conus geographus. Mar Drugs (2021) 19 [P, NA] |
| Belgi,A., Burnley,J.V., MacRaild,C.A., Chhabra,S., Elnahriry,K.A., Robinson,S.D., Gooding,S.G., Tae,H.S., Bartels,P., Sadeghi,M., Zhao,F.Y., Wei,H., Spanswick,D., Adams,D.J., Norton,R.S. and Robinson,A.J. Alkyne-Bridged α-Conotoxin Vc1.1 Potently Reverses Mechanical Allodynia in Neuropathic Pain Models. J Med Chem (2021) 64: 3222-3233 [P, NA] |
| Bosse,G.D., Urcino,C., Watkins,M., Flórez Salcedo,P., Kozel,S., Chase,K., Cabang,A., Espino,S.S., Safavi-Hemami,H., Raghuraman,S., Olivera,B.M., Peterson,R.T. and Gajewiak,J. Discovery of a Potent Conorfamide from Conus episcopatus Using a Novel Zebrafish Larvae Assay. J Nat Prod (2021) [P, NA] |
| Chen J, Liu X, Yu S, Liu J, Chen R, Zhang Y, Jiang L, Dai Q A novel ω-conotoxin Bu8 inhibiting N-type voltage-gated calcium channels displays potent analgesic activity. Acta Pharm Sin B (2021) 11: 2685-2693 [P, NA] |
| Fisher,F., Zhang,Y., Vincent,P.F.Y., Gajewiak,J., Gordon,T.J., Glowatzki,E., Fuchs,P.A. and McIntosh,J.M. Cy3-RgIA-5727 Labels and Inhibits α9-Containing nAChRs of Cochlear Hair Cells. Front Cell Neurosci (2021) 15: 697560-0 [P, NA] |
| Gajewiak J, Christensen SB, Dowell C, Hararah F, Fisher F, Huynh PN, Olivera BM, McIntosh JM Selective Penicillamine Substitution Enables Development of a Potent Analgesic Peptide that Acts through a Non-Opioid-Based Mechanism J Med Chem (2021) 64: 9271-9278 [P, NA] |
| Gao S, Yao X, Yan N. Structure of human Cav2.2 channel blocked by the painkiller ziconotide. Nature (2021) 596: 143-147 [P, NA] |
| Giribaldi,J., Haufe,Y., Evans,E.R.J., Wilson,D.T., Daly,N.L., Enjalbal,C., Nicke,A. and Dutertre,S. Synthesis, Structural and Pharmacological Characterizations of CIC, a Novel α-Conotoxin with an Extended N-Terminal Tail. Mar Drugs (2021) 19 [P, NA] |
| Gulsevin,A., Papke,R.L., Stokes,C., Tran,H.N.T., Jin,A.H., Vetter,I. and Meiler,J. The Allosteric Activation of α7 nAChR by α-Conotoxin MrIC Is Modified by Mutations at the Vestibular Site. Toxins (Basel) (2021) 13 [P, NA] |
| Hasan,M.M., Starobova,H., Mueller,A., Vetter,I. and Lewis,R.J. Subcutaneous ω-Conotoxins Alleviate Mechanical Pain in Rodent Models of Acute Peripheral Neuropathy. Mar Drugs (2021) 19 [P, NA] |
| Ho,T.N.T., Abraham,N., Lewis,R.J. Unique Pharmacological Properties of α-Conotoxin OmIA at α7 nAChRs. Front Pharmacol (2021) 12: 803397-0 [P, NA] |
| Ho,T.N.T., Abraham,N., Lewis,R.J. Rigidity of loop 1 contributes to equipotency of globular and ribbon isomers of α-conotoxin AusIA Sci Rep (2021) 11: 21928-0 [P, NA] |
| Ho,T.N.T., Lee,H.S., Swaminathan,S., Goodwin,L., Rai,N., Ushay,B., Lewis,R.J. and Conibear,A.C. Posttranslational modifications of α-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. RSC Med Chem (2021) 12: 1574-1584 [P, NA] |
| Hone,A.J., Kaas,Q., Kearns,I., Hararah,F., Gajewiak,J., Christensen,S., Craik,D.J. and McIntosh,J.M. Computational and Functional Mapping of Human and Rat α6β4 Nicotinic Acetylcholine Receptors Reveals Species-Specific Ligand-Binding Motifs. J Med Chem (2021) 64: 1685-1700 [P, NA] |
| Jain,R.P., Jayaseelan,B.F., Wilson Alphonse,C.R., Mahmoud,A.H., Mohammed,O.B., Ahmed Almunqedhi,B.M., and Rajaian Pushpabai,R. Mass spectrometric identification and denovo sequencing of novel conotoxins from vermivorous cone snail (Conus inscriptus), and preliminary screening of its venom for biological activities in vitro and in vivo. Saudi J Biol Sci (2021) 28: 1582-1595 [P, NA] |
| Kumari, A., Ameri, S., Marraiki, N., Elgorban, A.M., Aroulmoji, V., Ponnuchamy, K., Govarthanan, M., Selvankumar, T. Isolation, Characterization and In-Silico Study of Conotoxin Protein from Conus loroisii and Its Anti-cancer Activity International Journal of Peptide Research and Therapeutics (2021) 27: 385-395 [P, NA] |
| Lugo-Fabres,P.H., Otero-Sastre,L.M., Bernáldez-Sarabia,J., Camacho-Villegas,T.A., Sánchez-Campos,N., Serrano-Bello,J., Medina,L.A., Muñiz-Hernández,S., de la Cruz,L., Arenas,I., Barajas-Martínez,A., Garcia,D.E., Nuñez-Garcia,L., González-Canudas,J. and Licea-Navarro,A.F. Potential Therapeutic Applications of Synthetic Conotoxin s-cal14.2b, Derived from Californiconus californicus, for Treating Type 2 Diabetes Biomedicines (2021) 9 [P, NA] |
| Ma X, Huang Q, Yu S, Xu S, Huang Y, Zhao Z, Xiao X, Dai Q. The 3/4- and 3/6-Subfamily Variants of α-Conotoxins GI and MI Exhibit Potent Inhibitory Activity against Muscular Nicotinic Acetylcholine Receptors Mar Drugs (2021) 19: 705-0 [P, NA] |
| Martin,L., Ibrahim,M., Gomez,K., Yu,J., Cai,S., Chew,L.A., Bellampalli,S.S., Moutal,A., Largent-Milnes,T., Porreca,F., Khanna,R. and Patwardhan,A. Conotoxin contulakin-G engages a neurotensin receptor 2 /R-type calcium channel (Cav2.3) pathway to mediate spinal antinociception. Pain (2021) [P, NA] |
| Pan,S., Fan,Y., Zhu,X., Xue,Y., Luo,S., Wang,X. From Crystal Structures of RgIA4 in Complex with Ac-AChBP to Molecular Determinants of Its High Potency of α9α10 nAChR. Mar Drugs (2021) 19: 709-0 [P, NA] |
| Qiang,Y.Y., Wu,Y., Zhao,D., Zhao,B., Wang,F., Ren,S., Wen,Y., Gu,J., Zhang,L., Liu,K., Niu,J. and Wang,L. Discovery and Characterization of the Novel Conotoxin Lv1d from Conus lividus that Presents Analgesic Activity. Toxicon (2021) [P, NA] |
| Rajaian Pushpabai,R., Wilson Alphonse,C.R., Mani,R., Arun Apte,D. and Franklin,J.B. Diversity of Conopeptides and Conoenzymes from the Venom Duct of the Marine Cone Snail Conus bayani as Determined from Transcriptomic and Proteomic Analyses. Mar Drugs (2021) 19 [P, NA] |
| Terpinskaya,T.I., Osipov,A.V., Kryukova,E.V., Kudryavtsev,D.S., Kopylova,N.V., Yanchanka,T.L., Palukoshka,A.F., Gondarenko,E.A., Zhmak,M.N., Tsetlin,V.I. and Utkin,Y.N. α-Conotoxins and α-Cobratoxin Promote, while Lipoxygenase and Cyclooxygenase Inhibitors Suppress the Proliferation of Glioma C6 Cells. Mar Drugs (2021) 19 [P, NA] |
| Wang, S., Zhu, X., Zhangsun, M., Wu, Y., Yu, J., Harvey, P. J., Kaas, Q., Zhangsun, D., Craik, D. J., & Luo, S. Engineered Conotoxin Differentially Blocks and Discriminates Rat and Human α7 Nicotinic Acetylcholine Receptors Journal of Medicinal Chemistry (2021) 64: 5620-5631 [P, NA] |
| Wang,S., Ren,J., Li,R., Li,X., Zhangsun,D., Wu,Y. and Luo,S. Synthesis and evaluation of disulfide-rich cyclic α-conotoxin [S9A]TxID analogues as novel α3β4 nAChR antagonists. Bioorg Chem (2021) 112: 104875-0 [P, NA] |
| Wei,N., Chu,Y., Liu,H., Xu,Q. and Yu,R. Antagonistic Mechanism of α-Conotoxin BuIA toward the Human α3β2 Nicotinic Acetylcholine Receptor. ACS Chem Neurosci (2021) 12: 4535-4545 [P, NA] |
| Wu Y, Qiang Y, Zhang G, Zhou M. Acute toxicity and micronucleus test of conotoxin lt14a in mice. Basic Clin Pharmacol Toxicol (2021) 129: 52-60 [P, NA] |
| Wu,X., Craik,D.J., Kaas,Q. Interactions of Globular and Ribbon [γ4E]GID with α4β2 Neuronal Nicotinic Acetylcholine Receptor. Mar Drugs (2021) 19: 482-0 [P, NA] |
| Yang Y, Tan Y, Zhangsun D, Zhu X, Luo S. Design, Synthesis, and Activity of an α-Conotoxin LtIA Fluorescent Analogue ACS Chem Neurosci (2021) 12: 3662-3671 [P, NA] |
| Yang,M., Li,Y., Liu,L., Zhou,M. A novel proline-rich M-superfamily conotoxin that can simultaneously affect sodium, potassium and calcium currents J Venom Anim Toxins Incl Trop Dis (2021) 27 [P, NA] |
| Yousuf,A., Wu,X., Bony,A.R., Sadeghi,M., Huang,Y.H., Craik,D.J., Adams,D.J. αO-Conotoxin GeXIVA isomers modulate N-type calcium (CaV 2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABAB receptor activation J Neurochem (2021) [P, NA] |
| Zhang,B., Ren,M., Xiong,Y., Li,H., Wu,Y., Fu,Y., Zhangsun,D., Dong,S. and Luo,S. Cysteine [2,4] Disulfide Bond as a New Modifiable Site of α-Conotoxin TxIB. Mar Drugs (2021) 19 [P, NA] |
| Zheng N, Christensen SB, Dowell C, Purushottam L, Skalicky JJ, McIntosh JM, Chou DH. Discovery of Methylene Thioacetal-Incorporated α-RgIA Analogues as Potent and Stable Antagonists of the Human α9β10 Nicotinic Acetylcholine Receptor for the Treatment of Neuropathic Pain J Med Chem (2021) 64: 9513-9524 [P, NA] |
2020 AlSharari,S.D., Toma,W., Mahmood,H.M., Michael McIntosh,J. and Imad Damaj,M. The α9α10 nicotinic acetylcholine receptors antagonist α-conotoxin RgIA reverses colitis signs in murine dextran sodium sulfate model Eur. J. Pharmacol. (2020) 173320 [P, NA] |
| Bao,N., Lecaer,J.P., Nghia,N.D. and Vinh,P.T.K. Isolation and structural identification of a new T1-conotoxin with unique disulfide connectivities derived from Conus bandanus J Venom Anim Toxins Incl Trop Dis (2020) 26 [P, NA] |
| Dutt,M., Giacomotto,J., Ragnarsson,L., Andersson,A., Brust,A., Deakan,Z., Alewood,P.F. and Lewis,R.J. Re-evaluating the nirvana cabal deployed by piscivorous cone snails Toxicon (2020) 177 [P, NA] |
| Giribaldi,J., Ragnarsson,L., Pujante,T., Enjalbal,C., Wilson,D., Daly,N.L., Lewis,R.J. and Dutertre,S Synthesis, Pharmacological and Structural Characterization of Novel Conopressins from Conus miliaris Marine drugs (2020) 18 [P, NA] |
| Hone,A.J., Rueda-Ruzafa,L., Gordon,T.J., Gajewiak,J., Christensen,S., Dyhring,T., Albillos,A. and McIntosh,J.M. Expression of α3β2β4 nicotinic acetylcholine receptors by rat adrenal chromaffin cells determined using novel conopeptide antagonists J Neurochem (2020) [P, NA] |
| Huynh,P.N., Harvey,P.J., Gajewiak,J., Craik,D.J. and Michael McIntosh,J. Critical residue properties for potency and selectivity of α-Conotoxin RgIA towards α9α10 nicotinic acetylcholine receptors. Biochem. Pharmacol. (2020) : 114124-0 [P, NA] |
| Itang,C.E.M.M., Gaza,J.T., Masacupan,D.J.M., Batoctoy,D.C.R., Chen,Y.J., Nellas,R.B. and Yu,E.T. Identification of Conomarphin Variants in the Conus eburneus Venom and the Effect of Sequence and PTM Variations on Conomarphin Conformations. Mar Drugs (2020) 18 [P, NA] |
| Kumar,S., Vijayasarathy,M., Venkatesha,M.A., Sunita,P. and Balaram,P. Cone Snail Analogs of the Pituitary Hormones Oxytocin/Vasopressin and Their Carrier Protein Neurophysin. Proteomic and Transcriptomic Identification of Conopressins and Conophysins Biochim Biophys Acta Proteins Proteom (2020) 1868: 140391-0 [P, NA] |
| López-Vera,E., Martínez-Hernández,L., Aguilar,M.B., Carrillo,E. and Gajewiak,J. Studies of Conorfamide-Sr3 on Human Voltage-Gated Kv1 Potassium Channel Subtypes. Mar Drugs (2020) 18 [P, NA] |
| Li,X., Chen,W., Zhangsun,D. and Luo,S. Diversity of Conopeptides and Their Precursor Genes of Conus Litteratus. Mar Drugs (2020) 18 [P, NA] |
| Li,X., Wang,S., Zhu,X., Zhangsun,D., Wu,Y. and Luo,S Effects of Cyclization on Activity and Stability of α-Conotoxin TxIB Mar Drugs (2020) 18 [P, NA] |
| Liang,J., Tae,H.S., Xu,X., Jiang,T., Adams,D.J. and Yu,R Dimerization of α-Conotoxins as a Strategy to Enhance the Inhibition of the Human α7 and α9α10 Nicotinic Acetylcholine Receptors J. Med. Chem (2020) 63: 2974-2985 [P, NA] |
| Liu,X., Yao,G., Wang,K., Liu,Y., Wan,X. and Jiang,H Structural and Functional Characterization of Conotoxins from Conus achatinus Targeting NMDAR Marine drugs (2020) 18 [P, NA] |
| McMahon,K.L., Tran,H.N.T., Deuis,J.R., Lewis,R.J., Vetter,I. and Schroeder,C.I. Discovery, Pharmacological Characterisation and NMR Structure of the Novel µ-Conotoxin SxIIIC, a Potent and Irreversible NaV Channel Inhibitor. Biomedicines (2020) 8 [P, NA] |
| Mohan,M.K., Abraham,N., R P,R., Jayaseelan,B.F., Ragnarsson,L., Lewis,R.J. and Sarma,S.P Structure and allosteric activity of a single-disulfide conopeptide from Conus zonatus at human α3β4 and α7 nicotinic acetylcholine receptors J. Biol. Chem. (2020) 295: 7096-7112 [P, NA] |
| Osipov,A.V., Terpinskaya,T.I., Yanchanka,T., Balashevich,T., Zhmak,M.N., Tsetlin,V.I. and Utkin,Y.N α-Conotoxins Enhance both the In Vivo Suppression of Ehrlich carcinoma Growth and In Vitro Reduction in Cell Viability Elicited by Cyclooxygenase and Lipoxygenase Inhibitors Mar Drugs (2020) 18 [P, NA] |
| Rybin, M.J., O′Brien, H., Ramiro, I.B.L., Azam, L., McIntosh, J.M., Olivera, B.M., Safavi-Hemami, H. and Yoshikami, D. αM-Conotoxin MIIIJ Blocks Nicotinic Acetylcholine Receptors at Neuromuscular Junctions of Frog and Fish Toxins (Basel) (2020) 12 [P, NA] |
| Schmitz,T., Pengelley,S., Belau,E. and Imhof,D. LC-Trapped Ion Mobility Spectrometry-TOF MS Differentiation of 2- and 3-Disulfide-Bonded Isomers of the µ-Conotoxin PIIIA. Anal Chem (2020) 92: 10920-10924 [P, NA] |
| Sun,Z., Bao,J., Zhangsun,M., Dong,S., Zhangsun,D. and Luo,S. αO-Conotoxin GeXIVA Inhibits the Growth of Breast Cancer Cells via Interaction with α9 Nicotine Acetylcholine Receptors Mar Drugs (2020) 18: 195-0 [P, NA] |
| Wang D, Himaya SWA, Giacomotto J, Hasan MM, Cardoso FC, Ragnarsson L, Lewis RJ. Characterisation of δ-Conotoxin TxVIA as a Mammalian T-Type Calcium Channel Modulator Mar Drugs (2020) 18: 343-0 [P, NA] |
| Wilson,D.T., Bansal,P.S., Carter,D.A., Vetter,I., Nicke,A., Dutertre,S. and Daly,N.L. Characterisation of a Novel A-Superfamily Conotoxin Biomedicines (2020) 8: 128-0 [P, NA] |
| Xu, P., Kaas, Q., Wu, Y., Zhu, X., Li, X., Harvey, P.J., Zhangsun, D., Craik, D.J. and Luo, S Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA Journal of Medicinal Chemistry (2020) [P, NA] |
| Xu,Q., Tae,H.S., Wang,Z., Jiang,T., Adams,D.J. and Yu,R. Rational Design of α-Conotoxin RegIIA Analogues Specifically Inhibiting the Human α3β2 Nicotinic Acetylcholine Receptor through Computational Scanning ACS Chem Neurosci (2020) [P, NA] |
| Yang,M. and Zhou,M Insertions and Deletions Play an Important Role in the Diversity of Conotoxins Protein J. (2020) 39: 190-195 [P, NA] |
| Yang,M. and Zhou,M. µ-conotoxin TsIIIA, a peptide inhibitor of human voltage-gated sodium channel hNav1.8. Toxicon (2020) 186: 29-34 [P, NA] |
| Zhu,X., Pan,S., Xu,M., Zhang,L., Yu,J., Yu,J., Wu,Y., Fan,Y., Li,H., Kasheverov,I.E., Kudryavtsev,D.S., Tsetlin,V.I., Xue,Y., Zhangsun,D., Wang,X. and Luo,S. High Selectivity of an α-Conotoxin LvIA Analogue for α3β2 Nicotinic Acetylcholine Receptors Is Mediated by β2 Functionally Important Residues. J Med Chem (2020) 63: 13656-13668 [P, NA] |
2019 Ahorukomeye, P., Disotuar, M.M., Gajewiak, J., Karanth, S., Watkins, M., Robinson, S.D., Salcedo, P.F., Smith, N.A., Smith, B.J., Schlegel, A. and Forbes, B.E. Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor eLife (2019) 8 [P, NA] |
| Bernáldez-Sarabia,J., Figueroa-Montiel,A., Dueñas,S., Cervantes-Luévano,K., Beltrán,J.A., Ortiz,E., Jiménez,S., Possani,L.D., Paniagua-Solís,J.F., Gonzalez-Canudas,J., and Licea-Navarro,A. The Diversified O-Superfamily in Californiconus californicus Presents a Conotoxin with Antimycobacterial Activity Toxins (2019) 11: 128-0 [P, NA] |
| Chu,X., Tae,H.S., Xu,Q., Jiang,T., Adams,D.J. and Yu,R α-Conotoxin Vc1.1 Structure-Activity Relationship at the Human α9α10 Nicotinic Acetylcholine Receptor Investigated by Minimal Side Chain Replacement ACS Chem Neurosci (2019) 10: 4328-4336 [P, NA] |
| Cordeiro,S., Finol-Urdaneta,R.K., Köpfer,D., Markushina,A., Song,J., French,R.J., Kopec,W., de Groot,B.L., Giacobassi,M.J., Leavitt,L.S., Raghuraman,S., Teichert,R.W., Olivera,B.M., and Terlau,H. Conotoxin κM-RIIIJ, a tool targeting asymmetric heteromeric Kv1 channels Proceedings of the National Academy of Sciences (2019) 116: 1059-1064 [P, NA] |
| Dutt, M., Dutertre, S., Jin, A.H., Lavergne, V., Alewood, P.F. and Lewis, R.J. Venomics reveals venom complexity of the piscivorous cone snail, Conus tulipa Marine drugs (2019) 17: 71-0 [P, NA] |
| Dutt,M., Giacomotto,J., Ragnarsson,L., Andersson,Å., Brust,A., Dekan,Z., Alewood,P.F., and Lewis,R.J. The α1-adrenoceptor inhibitor ρ-TIA facilitates net hunting in piscivorous Conus tulipa Scientific reports (2019) 9: 17841-0 [P, NA] |
| El Hamdaoui,Y., Wu,X., Clark,R.J., Giribaldi,J., Anangi,R., Craik,D.J., King,G.F., Dutertre,S., Kaas,Q., Herzig,V. and Nicke,A. Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation - Suggestion of a Binding Mode at the α7 nAChR. Front Pharmacol (2019) 10: 577-0 [P, NA] |
| Fassio, G., Modica, M.V., Mary, L., Zaharias, P., Fedosov, A.E., Gorson, J., Kantor, Y.I., Holford, M. and Puillandre, N. Venom Diversity and Evolution in the Most Divergent Cone Snail Genus Profundiconus Toxins (2019) 11: 623-0 [P, NA] |
| Finol-Urdaneta, R.K., McArthur, J.R., Korkosh, V.S., Huang, S., McMaster, D., Glavica, R., Tikhonov, D.B., Zhorov, B.S. and French, R.J. Extremely Potent Block of Bacterial Voltage-Gated Sodium Channels by μ-Conotoxin PIIIA Marine drugs (2019) 17: 510-527 [P, NA] |
| Hernández-Sámano,A.C., Falcón,A., Zamudio,F., Batista,C.V.F., Michel-Morfín,J.E., Landa-Jaime,V., López-Vera,E., Jeziorski,M.C. and Aguilar,M.B. αD-Conotoxins in Species of the Eastern Pacific: The Case of Conus princeps from Mexico. Toxins (Basel) (2019) 11: 405-0 [P, NA] |
| Hone,A.J., Fisher,F., Christensen,S., Gajewiak,J., Larkin,D., Whiteaker,P. and McIntosh,J.M. PeIA-5466: A Novel Peptide Antagonist Containing Non-natural Amino Acids That Selectively Targets α3β2 Nicotinic Acetylcholine Receptors J. Med. Chem. (2019) 62: 6262-6275 [P, NA] |
| Huynh,P.N., Giuvelis,D., Christensen,S., Tucker,K.L. and McIntosh,J.M. RgIA4 Accelerates Recovery from Paclitaxel-Induced Neuropathic Pain in Rats Mar Drugs (2019) 18: 12-0 [P, NA] |
| Jin, A.H., Cristofori-Armstrong, B., Rash, L.D., Román-González, S.A., Espinosa, R.A., Lewis, R.J., Alewood, P.F. and Vetter, I Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels Biochemical pharmacology (2019) 164: 342-348 [P, NA] |
| Jin, A.H., Dutertre, S., Dutt, M., Lavergne, V., Jones, A., Lewis, R.J. and Alewood, P.F. Transcriptomic-Proteomic Correlation in the Predation-Evoked Venom of the Cone Snail, Conus imperialis Marine drugs (2019) 17: 177-0 [P, NA] |
| Kondasinghe, T.D., Saraha, H.Y., Jackowski, S.T. and Stockdill, J.L. Raising the bar on-bead: Efficient on-resin synthesis of α-conotoxin LvIA Tetrahedron letters (2019) 60: 23-28 [P, NA] |
| Liu, C., Wu, P., Zhu, H., Grieco, P., Yu, R., Gao, X., Wu, G., Wang, D., Xu, H. and Qi, W. Rationally Designed α-Conotoxin Analogues Maintained Analgesia Activity and Weakened Side Effects Molecules (2019) 24: 337-0 [P, NA] |
| Möller, C., Davis, W.C., Clark, E., DeCaprio, A. and Mari, F. Conodipine-P1-3, the First Phospholipases A2 Characterized from Injected Cone Snail Venom Molecular & Cellular Proteomics (2019) 18: 876-891 [P, NA] |
| Mendoza,C.B., Masacupan,D.J.M., Batoctoy,D.C.R., Yu,E.T., Lluisma,A.O. and Salvador-Reyes,L.A. Conomarphins cause paralysis in mollusk: Critical and tunable structural elements for bioactivity. J. Pept. Sci. (2019) 25 [P, NA] |
| Neves,J.L.B., Imperial,J.S., Morgenstern,D., Ueberheide,B., Gajewiak,J., Antunes,A., Robinson,S.D., Espino,S., Watkins,M., Vasconcelos,V. and Olivera,B.M. Characterization of the First Conotoxin from Conus ateralbus, a Vermivorous Cone Snail from the Cabo Verde Archipelago Mar Drugs (2019) 17: 432-0 [P, NA] |
| Nielsen, L.D., Foged, M.M., Albert, A., Bertelsen, A.B., Søltoft, C.L., Robinson, S.D., Petersen, S.V., Purcell, A.W., Olivera, B.M., Norton, R.S. and Vasskog, T. The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework Journal of Biological Chemistry (2019) 294: 8745-8759 [P, NA] |
| Ning,J., Ren,J., Xiong,Y., Wu,Y., Zhangsun,M., Zhangsun,D., Zhu,X. and Luo,S. Identification of Crucial Residues in α-Conotoxin EI Inhibiting Muscle Nicotinic Acetylcholine Receptor Toxins (Basel) (2019) 11: 603-0 [P, NA] |
| Oroz-Parra,I., Ãlvarez-Delgado,C., Cervantes-Luevano,K., Dueñas-Espinoza,S. and Licea-Navarro,A.F. Proapoptotic Index Evaluation of Two Synthetic Peptides Derived from the Coneshell Californiconus californicus in Lung Cancer Cell Line H1299 Mar Drugs (2019) 18: 10-0 [P, NA] |
| Pan,X., Li,Z., Huang,X., Huang,G., Gao,S., Shen,H., Liu,L., Lei,J. and Yan,N. Molecular basis for pore blockade of human Na+ channel Nav1.2 by the μ-conotoxin KIIIA. Science (2019) eaaw2999 [P, NA] |
| Pardos-Blas,J.R., Irisarri,I., Abalde,S., Tenorio,M.J. and Zardoya,R. Conotoxin Diversity in the Venom Gland Transcriptome of the Magician Marine drugs (2019) 17: 453-0 [P, NA] |
| Patil, N.A., Karas, J.A., Wade, J.D., Hossain, M.A. and Tailhades, J. Rapid Photolysis-Mediated Folding of Disulfide-Rich Peptides Chemistry–A European Journal (2019) 25: 8599-8603 [P, NA] |
| Peigneur,S., Devi,P., Seldeslachts,A., Ravichandran,S., Quinton,L. and Tytgat,J. Structure-Function Elucidation of a New α-Conotoxin, MilIA, from Conus milneedwardsi Mar Drugs (2019) 17: 535-0 [P, NA] |
| Phuong,M.A., Alfaro,M.E., Mahardika,G.N., Marwoto,R.M., Prabowo,R.E., von Rintelen,T., Vogt,P.W.H., Hendricks,J.R. and Puillandre,N. Lack of Signal for the Impact of Conotoxin Gene Diversity on Speciation Rates in Cone Snails Syst. Biol. (2019) 68: 781-796 [P, NA] |
| Ren, J., Zhu, X., Xu, P., Li, R., Fu, Y., Dong, S., Zhangsun, D., Wu, Y. and Luo, S. d-Amino Acid Substitution of α-Conotoxin RgIA Identifies its Critical Residues and Improves the Enzymatic Stability Marine drugs (2019) 17: 142-0 [P, NA] |
| Van Hout, M., Valdes, A., Christensen, S.B., Tran, P.T., Watkins, M., Gajewiak, J., Jensen, A.A., Olivera, B.M. and McIntosh, J.M. α-Conotoxin VnIB from Conus ventricosus is a potent and selective antagonist of α6β4* nicotinic acetylcholine receptors Neuropharmacology (2019) 157: 107691-0 [P, NA] |
| Vijayasarathy, M. and Balaram, P. Cone snail prolyl-4-hydroxylase α-subunit sequences derived from transcriptomic data and mass spectrometric analysis of variable proline hydroxylation in C. amadis venom Journal of proteomics (2019) 194: 37-48 [P, NA] |
| Wang, H., Li, X., Zhangsun, D., Yu, G., Su, R. and Luo, S. The α9α10 Nicotinic Acetylcholine Receptor Antagonist αO-Conotoxin GeXIVA[1,2] Alleviates and Reverses Chemotherapy-Induced Neuropathic Pain Marine drugs (2019) 17: 265-0 [P, NA] |
| Weese,D.A. and Duda,T.F. Jr. Effects of Predator-Prey Interactions on Predator Traits: Differentiation of Diets and Venoms of a Marine Snail Toxins (Basel) (2019) 11: 299-0 [P, NA] |
| Xu, X., Liang, J., Zhang, Z., Jiang, T. and Yu, R. Blockade of Human α7 Nicotinic Acetylcholine Receptor by α-Conotoxin ImI Dendrimer: Insight from Computational Simulations Marine drugs (2019) 17: 303-0 [P, NA] |
| Yao, G., Peng, C., Zhu, Y., Fan, C., Jiang, H., Chen, J., Cao, Y. and Shi, Q. High-Throughput Identification and Analysis of Novel Conotoxins from Three Vermivorous Cone Snails by Transcriptome Sequencing Marine drugs (2019) 17: 193-0 [P, NA] |
| You,S., Li,X., Xiong,J., Zhu,X., Zhangsun,D., Zhu,X. and Luo,S. α-Conotoxin TxIB: A Uniquely Selective Ligand for α6/α3β2β3 Nicotinic Acetylcholine Receptor Attenuates Nicotine-Induced Conditioned Place Preference in Mice Mar Drugs (2019) 17: 490-0 [P, NA] |
| Zazueta-Favela,D., Donis-Maturano,L., Licea-Navarro,A.F., Bernáldez-Sarabia,J., Dan,K.W.L., Cota-Arce,J.M., Escobedo,G. and De León-Nava,M.A. Marine peptides as immunomodulators: Californiconus californicus-derived synthetic conotoxins induce IL-10 production by regulatory T cells (CD4+Foxp3+) Immunopharmacol Immunotoxicol (2019) 41: 463-468 [P, NA] |
| Zhang, H., Fu, Y., Wang, L., Liang, A., Chen, S. and Xu, A. Identifying novel conopepetides from the venom ducts of Conus litteratus through integrating transcriptomics and proteomics Journal of proteomics (2019) 192: 346-357 [P, NA] |
| Ziegman, R., Brust, A., Jha, P., Cardoso, F.C., Lewis, R.J. and Alewood, P.F. ‘Messy’Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency Marine drugs (2019) 17: 165-0 [P, NA] |
2018 Abalde, S., Tenorio, M.J., Afonso, C.M. and Zardoya, R. Conotoxin diversity in Chelyconus ermineus (Born, 1778) and the convergent origin of piscivory in the Atlantic and Indo-Pacific cones Genome biology and evolution (2018) 10: 2643-2662 [P, NA] |
| Armstrong,D.A., Kaas,Q. and Rosengren,K.J. Prediction of disulfide dihedral angles using chemical shifts. Chem Sci (2018) 9: 6548-6556 [P, NA] |
| Cai,F., Xu,N., Liu,Z., Ding,R., Yu,S., Dong,M., Wang,S., Shen,J., Tae,H.S., Adams,D.J., Zhang,X. and Dai,Q. Targeting of N-Type Calcium Channels via GABAB-Receptor Activation by α-Conotoxin Vc1.1 Variants Displaying Improved Analgesic Activity J. Med. Chem. (2018) 61: 10198-10205 [P, NA] |
| Castro J, Grundy L, Deiteren A, Harrington AM, O Donnell T, Maddern J, Moore J, Garcia-Caraballo S, Rychkov GY, Yu R, Kaas Q, Craik DJ, Adams DJ, Brierley SM Cyclic analogues of αâ€conotoxin Vc1. 1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain British journal of pharmacology (2018) 175: 2384-2398 [P, NA] |
| Chen J, Liang L, Ning H, Cai F, Liu Z, Zhang L, Zhou L, Dai Q Cloning, Synthesis and Functional Characterization of a Novel α-Conotoxin Lt1.3 Marine drugs (2018) 16: 112-0 [P, NA] |
| Chen, F., Huang, W., Jiang, T. and Yu, R. Determination of the μ-Conotoxin PIIIA Specificity Against Voltage-Gated Sodium Channels from Binding Energy Calculations Marine drugs (2018) 16: 153-0 [P, NA] |
| Espino, S.S., Robinson, S.D., Safavi-Hemami, H., Gajewiak, J., Yang, W., Olivera, B.M. and Liu, Q. Conopeptides promote itch through human itch receptor hMgprX1 Toxicon (2018) 154: 28-34 [P, NA] |
| Figueroa-Montiel, A., Bernáldez, J., Jiménez, S., Ueberhide, B., González, L. and Licea-Navarro, A. Antimycobacterial activity: A new pharmacological target for conotoxins found in the first reported conotoxin from Conasprella ximenes Toxins (2018) 10: 51-0 [P, NA] |
| Franco,A., Dovell,S., Möller,C., Grandal,M., Clark,E. and Marí,F. Structural plasticity of mini-M conotoxins - expression of all mini-M subtypes by Conus regius. FEBS J. (2018) 285: 887-902 [P, NA] |
| Gao,B., Peng,C., Zhu,Y., Sun,Y., Zhao,T., Huang,Y. and Shi,Q. High Throughput Identification of Novel Conotoxins from the Vermivorous Oak Cone Snail (Conus quercinus) by Transcriptome Sequencing Int J Mol Sci (2018) 19: 3901-0 [P, NA] |
| Giribaldi, J., Wilson, D., Nicke, A., El Hamdaoui, Y., Laconde, G., Faucherre, A., Moha Ou Maati, H., Daly, N., Enjalbal, C. and Dutertre, S. Synthesis, structure and biological activity of CIA and CIB, two α-conotoxins from the predation-evoked venom of Conus catus Toxins (2018) 10: 222-0 [P, NA] |
| Grau, V., Richter, K., Hone, A.J. and McIntosh, J.M. Conopeptides [V11L; V16D] ArIB and RgIA4: powerful tools for the identification of novel nicotinic acetylcholine receptors in monocytes Frontiers in pharmacology (2018) 9 [P, NA] |
| Harvey,P.J., Kurniawan,N.D., Finol-Urdaneta,R.K., McArthur,J.R., Van Lysebetten,D., Dash,T.S., Hill,J.M., Adams,D.J., Durek,T. and Craik,D.J. NMR Structure of μ-Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced NaV Channel Potency Molecules (2018) 23: 2715-0 [P, NA] |
| Heimer, P., Tietze, A.A., Bäuml, C.A., Resemann, A., Mayer, F.J., Suckau, D., Ohlenschläger, O., Tietze, D. and Imhof, D. Conformational μ-conotoxin PIIIA isomers revisited: Impact of cysteine pairing on disulfide-bond assignment and structure elucidation Analytical chemistry (2018) 90: 3321-3327 [P, NA] |
| Heimer,P., Schmitz,T., Bäuml,C.A. and Imhof,D. Synthesis and Structure Determination of μ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities. J Vis Exp (2018) [P, NA] |
| Himaya, S.W.A., Mari, F. and Lewis, R.J. Accelerated proteomic visualization of individual predatory venoms of Conus purpurascens reveals separately evolved predation-evoked venom cabals Scientific reports (2018) 8: 1-8 [P, NA] |
| Hone, A.J., Talley, T.T., Bobango, J., Melo, C.H., Hararah, F., Gajewiak, J., Christensen, S., Harvey, P.J., Craik, D.J. and McIntosh, J.M. Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors Journal of Biological Chemistry (2018) 293: 17838-17852 [P, NA] |
| Li, Q., Watkins, M., Robinson, S., Safavi-Hemami, H. and Yandell, M. Discovery of Novel Conotoxin Candidates Using Machine Learning Toxins (2018) 10: 503-0 [P, NA] |
| Liu,Z., Bartels,P., Sadeghi,M., Du,T., Dai,Q., Zhu,C., Yu,S., Wang,S., Dong,M., Sun,T. and Guo,J. A novel α-conopeptide Eu1.6 inhibits N-type (Ca V 2.2) calcium channels and exhibits potent analgesic activity Scientific reports (2018) 8: 1004-0 [P, NA] |
| Möller, C., Dovell, S., Melaun, C. and Marí, F. Definition of the R-superfamily of conotoxins: Structural convergence of helix-loop-helix peptidic scaffolds Peptides (2018) 107: 75-82 [P, NA] |
| Mei, D., Zhao, L., Chen, B., Zhang, X., Wang, X., Yu, Z., Ni, X. and Zhang, Q. α-Conotoxin ImI-modified polymeric micelles as potential nanocarriers for targeted docetaxel delivery to α7-nAChR overexpressed non-small cell lung cancer Drug Delivery (2018) 25: 493-503 [P, NA] |
| Ning,J., Li,R., Ren,J., Zhangsun,D., Zhu,X., Wu,Y. and Luo,S. Alanine-Scanning Mutagenesis of α-Conotoxin GI Reveals the Residues Crucial for Activity at the Muscle Acetylcholine Receptor Mar Drugs (2018) 16: 507-0 [P, NA] |
| Paul George,A.A., Heimer,P., Maaß,A., Hamaekers,J., Hofmann-Apitius,M., Biswas,A. and Imhof,D. Insights into the Folding of Disulfide-Rich μ-Conotoxins ACS Omega (2018) 3: 12330-12340 [P, NA] |
| Phuong, M.A. and Mahardika, G.N. Targeted Sequencing of Venom Genes from Cone Snail Genomes Improves Understanding of Conotoxin Molecular Evolution Molecular biology and evolution (2018) 35: 1210-1224 [P, NA] |
| Sadeghi M, Carstens BB, Callaghan BP, Daniel JT, Tae HS, O Donnell T, Castro J, Brierley SM, Adams DJ, Craik DJ, Clark RJ Structure-Activity Studies Reveal the Molecular Basis for GABAB-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by α-Conotoxin Vc1.1. ACS Chem. Biol. (2018) 13: 1577-1587 [P, NA] |
| Sousa,S.R., McArthur,J.R., Brust,A., Bhola,R.F., Rosengren,K.J., Ragnarsson,L., Dutertre,S., Alewood,P.F., Christie,M.J., Adams,D.J., Vetter,I. and Lewis,R.J. Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides. Sci Rep (2018) 8: 13397-0 [P, NA] |
| Vijayasarathy, M., Basheer, S.M. and Balaram, P. Cone Snail Glutaminyl Cyclase Sequences from Transcriptomic Analysis and Mass Spectrometric Characterization of Two Pyroglutamyl Conotoxins Journal of proteome research (2018) 17: 2695-2703 [P, NA] |
| Vijayasarathy,M. and Balaram,P Mass spectrometric identification of bromotryptophan containing conotoxin sequences from the venom of C. amadis Toxicon (2018) 144: 68-74 [P, NA] |
| Wilson,D. and Daly,N.L. Nuclear Magnetic Resonance seq (NMRseq): A New Approach to Peptide Sequence Tags Toxins (Basel) (2018) 10: 437-0 [P, NA] |
| Wu, X., Tae, H.S., Huang, Y.H., Adams, D.J., Craik, D.J. and Kaas, Q. Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB Biochemical pharmacology (2018) 155: 288-297 [P, NA] |
| Yu, J., Zhu, X., Harvey, P.J., Kaas, Q., Zhangsun, D., Craik, D.J. and Luo, S. Single Amino Acid Substitution in α-Conotoxin TxID Reveals a Specific α3β4 Nicotinic Acetylcholine Receptor Antagonist Journal of medicinal chemistry (2018) 61: 9256-9265 [P, NA] |
| Yu, J., Zhu, X., Zhang, L., Kudryavtsev, D., Kasheverov, I., Lei, Y., Zhangsun, D., Tsetlin, V. and Luo, S. Species specificity of rat and human α7 nicotinic acetylcholine receptors towards different classes of peptide and protein antagonists Neuropharmacology (2018) 139: 226-237 [P, NA] |
| Yu,J., Zhu,X., Yang,Y., Luo,S. and Zhangsun,D. Expression in Escherichia coli of fusion protein comprising α-conotoxin TxIB and preservation of selectivity to nicotinic acetylcholine receptors in the purified product Chem Biol Drug Des (2018) 91: 349-358 [P, NA] |
| Yu,R., Tae,H.S., Tabassum,N., Shi,J., Jiang,T. and Adams,D.J. Molecular Determinants Conferring the Stoichiometric-Dependent Activity of α-Conotoxins at the Human α9α10 Nicotinic Acetylcholine Receptor Subtype J. Med. Chem. (2018) 61: 4628-4634 [P, NA] |
2017 Abraham,N., Healy,M., Ragnarsson,L., Brust,A., Alewood,P.F. and Lewis,R.J. Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor. Sci Rep (2017) 7: 45466-0 [P, NA] |
| Campos-Lira, E., Carrillo, E., Aguilar, M.B., Gajewiak, J., Gómez-Lagunas, F. and López-Vera, E Conorfamide-Sr3, a structurally novel specific inhibitor of the Shaker K+ channel Toxicon (2017) 138: 53-58 [P, NA] |
| Castro,J., Harrington,A.M., Garcia-Caraballo,S., Maddern,J., Grundy,L., Zhang,J., Page,G., Miller,P.E., Craik,D.J., Adams,D.J. and Brierley,S.M. α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABAB receptors. (Unpublished) [P, NA] |
| Chittoor,B., Krishnarjuna,B., Morales,R.A.V., MacRaild,C.A., Sadek,M., Leung,E.W.W., Robinson,S.D., Pennington,M.W. and Norton,R.S. The Single Disulfide-Directed β-Hairpin Fold. Dynamics, Stability, and Engineering. Biochemistry (2017) 56: 2455-2466 [P, NA] |
| Christensen, S.B., Hone, A.J., Roux, I., Kniazeff, J., Pin, J.P., Upert, G., Servent, D., Glowatzki, E. and McIntosh, J.M. RgIA4 potently blocks mouse α9α10 nAChRs and provides long lasting protection against oxaliplatin-induced cold allodynia Frontiers in cellular neuroscience (2017) 11: 219-0 [P, NA] |
| Del Río-Sancho,S., Cros,C., Coutaz,B., Cuendet,M. and Kalia,Y.N. Cutaneous iontophoresis of μ-conotoxin CnIIIC-A potent NaV1.4 antagonist with analgesic, anaesthetic and myorelaxant properties. Int J Pharm (2017) 518: 59-65 [P, NA] |
| Drane,S.B., Robinson,S.D., MacRaild,C.A., Chhabra,S., Chittoor,B., Morales,R.A., Leung,E.W., Belgi,A., Espino,S.S., Olivera,B.M., Robinson,A.J., Chalmers,D.K. and Norton,R.S. Structure and activity of contryphan-Vc2: Importance of the d-amino acid residue. Toxicon (2017) 129: 113-122 [P, NA] |
| Echterbille,J., Gilles,N., Araóz,R., Mourier,G., Amar,M., Servent,D., De Pauw,E. and Quinton,L. Discovery and characterization of EIIB, a new α-conotoxin from Conus ermineus venom by nAChRs affinity capture monitored by MALDI-TOF/TOF mass spectrometry. Toxicon (2017) 130: 1-10 [P, NA] |
| El-Aziz,T.M.A., Ravelet,C., Molgo,J., Fiore,E., Pale,S., Amar,M., Al-Khoury,S., Dejeu,J., Fadl,M., Ronjat,M., Taiwe,G.S., Servent,D., Peyrin,E. and De Waard,M Efficient functional neutralization of lethal peptide toxins in vivo by oligonucleotides Sci Rep (2017) 78: 7202-0 [P, NA] |
| Gao,B., Peng,C., Lin,B., Chen,Q., Zhang,J. and Shi,Q. Screening and Validation of Highly-Efficient Insecticidal Conotoxins from a Transcriptome-Based Dataset of Chinese Tubular Cone Snail Toxins (Basel) (2017) 9: 214-0 [P, NA] |
| Hoggard, M.F., Rodriguez, A.M., Cano, H., Clark, E., Tae, H.S., Adams, D.J., Godenschwege, T.A. and Marí, F In vivo and in vitro testing of native α-conotoxins from the injected venom of Conus purpurascens Neuropharmacology (2017) 127: 253-259 [P, NA] |
| Jin, A.H., Dekan, Z., Smout, M.J., Wilson, D., Dutertre, S., Vetter, I., Lewis, R.J., Loukas, A., Daly, N.L. and Alewood, P.F. Conotoxin Φâ€MiXXVIIA from the Superfamily G2 Employs a Novel Cysteine Framework that Mimics Granulin and Displays Antiâ€Apoptotic Activity Angewandte Chemie International Edition (2017) 56: 14973-14976 [P, NA] |
| Leffler,A.E., Kuryatov,A., Zebroski,H.A., Powell,S.R., Filipenko,P., Hussein,A.K., Gorson,J., Heizmann,A., Lyskov,S., Tsien,R.W., Poget,S.F., Nicke,A., Lindstrom,J., Rudy,B., Bonneau,R. and Holford,M. Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models. Proc. Natl. Acad. Sci. U.S.A. (2017) 114 [P, NA] |
| Leipold,E., Ullrich,F., Thiele,M., Tietze,A.A., Terlau,H., Imhof,D. and Heinemann,S.H. Subtype-specific block of voltage-gated K+ channels by μ-conopeptides Biochem. Biophys. Res. Commun. (2017) 482: 1135-1140 [P, NA] |
| Li,Q., Barghi,N., Lu,A., Fedosov,A.E., Bandyopadhyay,P.K., Lluisma,A.O., Concepcion,G.P., Yandell,M., Olivera,B.M. and Safavi-Hemami,H. Divergence of the Venom Exogene Repertoire in Two Sister Species of Turriconus. Genome Biol Evol (2017) 9: 2211-2225 [P, NA] |
| Lu, J., Zhang, K., Wang, S., Sun, T., Yu, S., Dai, Q. and Liu, Z. Cloning, expression and functional characterization of a D-superfamily conotoxin Lt28. 1 with previously undescribed cysteine pattern Peptides, 94, pp.64-70 (2017) 94: 64-70 [P, NA] |
| Reimers,C., Lee,C.H., Kalbacher,H., Tian,Y., Hung,C.H., Schmidt,A., Prokop,L., Kauferstein,S., Mebs,D., Chen,C.C. and Gründer,S. Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain. Proc. Natl. Acad. Sci. U.S.A. (2017) 114 [P, NA] |
| Reyes-Guzman, E.A., Vega-Castro, N., Reyes-Montaño, E.A. and Recio-Pinto, E. Antagonistic action on NMDA/GluN2B mediated currents of two peptides that were conantokin-G structure-based designed BMC neuroscience (2017) 18: 44-0 [P, NA] |
| Robinson,S.D., Li,Q., Bandyopadhyay,P.K., Gajewiak,J., Yandell,M., Papenfuss,A.T., Purcell,A.W., Norton,R.S. and Safavi-Hemami,H. Hormone-like peptides in the venoms of marine cone snails. Gen. Comp. Endocrinol. (2017) 244: 11-18 [P, NA] |
| Romero,H.K., Christensen,S.B., Di Cesare Mannelli,L., Gajewiak,J., Ramachandra,R., Elmslie,K.S., Vetter,D.E., Ghelardini,C., Iadonato,S.P., Mercado,J.L., Olivera,B.M. and McIntosh,J.M. Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain. Proc Natl Acad Sci U S A (2017) 114 [P, NA] |
| Tabassum, N., Tae, H.S., Jia, X., Kaas, Q., Jiang, T., Adams, D.J. and Yu, R. Role of CysI-CysIII Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors ACS omega (2017) 2: 4621-4631 [P, NA] |
| Vijayasarathy,M., Basheer,S.M., Franklin,J.B. and Balaram,P. Contryphan Genes and Mature Peptides in the Venom of Nine Cone Snail Species by Transcriptomic and Mass Spectrometric Analysis. J. Proteome Res. (2017) 16: 763-772 [P, NA] |
| Wu X, Huang YH, Kaas Q, Harvey PJ, Wang CK, Tae HS, Adams DJ, Craik DJ. Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer J Biol Chem (2017) 292: 17101-17112 [P, NA] |
| Xu,M., Zhu,X., Yu,J., Yu,J., Luo,S. and Wang,X. The crystal structure of Ac-AChBP in complex with α-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes. Protein Cell (2017) 8: 675-685 [P, NA] |
| Yang,M., Zhao,S., Min,X., Shao,M., Chen,Y., Chen,Z. and Zhou,M. A novel μ-conotoxin from worm-hunting Conus tessulatus that selectively inhibit rat TTX-resistant sodium currents. Toxicon (2017) 130: 11-18 [P, NA] |
2016 Bernáldez,J., Jiménez,S., González,L.J., Ferro,J.N., Soto,E., Salceda,E., Chávez,D., Aguilar,M.B. and Licea-Navarro,A. A New Member of Gamma-Conotoxin Family Isolated from Conus princeps Displays a Novel Molecular Target. Toxins (Basel) (2016) 8: 39-0 [P, NA] |
| Brust,A., Croker,D.E., Colless,B., Ragnarsson,L., Andersson,A., Jain,K., Garcia-Caraballo,S., Castro,J., Brierley,S.M., Alewood,P.F., Lewis,R.J. Conopeptide-Derived κ-Opioid Agonists (Conorphins): Potent, Selective, and Metabolic Stable Dynorphin A Mimetics with Antinociceptive Properties J Med Chem (2016) [P, NA] |
| Carstens, B.B., Swedberg, J., Berecki, G., Adams, D.J., Craik, D.J. and Clark, R.J. Effects of linker sequence modifications on the structure, stability, and biological activity of a cyclic αâ€conotoxin Peptide Science (2016) 106: 864-875 [P, NA] |
| Carstens,B.B., Berecki,G., Daniel,J.T., Lee,H.S., Jackson,K.A., Tae,H.S., Sadeghi,M., Castro,J., O Structure-Activity Studies of Cysteine-Rich a-Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABA(B) Receptor Activation Reveal a Minimal Functional Motif. Angew. Chem. Int. Ed. Engl (2016) 55: 4692-4696 [P, NA] |
| Cuny,H., Kompella,S.N., Tae,H.S., Yu,R. and Adams,D.J. Key Structural Determinants in the Agonist Binding Loops of Human β2 and β4 Nicotinic Acetylcholine Receptor Subunits Contribute to α3β4 Subtype Selectivity of α-Conotoxins. J. Biol. Chem. (2016) 291: 23779-23792 [P, NA] |
| De León-Nava,M.A., Romero-Núñez,E., Luna-Nophal,A., Bernáldez-Sarabia,J., Sánchez-Campos,L.N., Licea-Navarro,A.F., Morales-Montor,J., and Muñiz-Hernández,S. In Vitro Effect of the Synthetic cal14.1a Conotoxin, Derived from Conus californicus, on the Human Parasite Toxoplasma gondii. Mar Drugs (2016) 14 [P, NA] |
| Deuis,J.R., Dekan,Z., Inserra,M.C., Lee,T.H., Aguilar,M.I., Craik,D.J., Lewis,R.J., Alewood,P.F., Mobli,M., Schroeder,C.I., Henriques,S.T. and Vetter,I. Development of a μO-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8. J. Biol. Chem. (2016) 291: 11829-11842 [P, NA] |
| Espino,S.S., Dilanyan,T., Imperial,J.S., Aguilar,M.B., Teichert,R.W., Bandyopadhyay,P. and Olivera,B.M. Glycine-rich conotoxins from the Virgiconus clade. Toxicon (2016) 113: 11-17 [P, NA] |
| Green,B.R., Gajewiak,J., Chhabra,S., Skalicky,J.J., Zhang,M.M., Rivier,J.E., Bulaj,G., Olivera,B.M., Yoshikami,D. and Norton,R.S. Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ. J. Biol. Chem. (2016) 291: 7205-7220 [P, NA] |
| Han, P., Wang, K., Dai, X., Cao, Y., Liu, S., Jiang, H., Fan, C., Wu, W. and Chen, J. The Role of Individual Disulfide Bonds of μ-Conotoxin GIIIA in the Inhibition of Nav1. 4 Marine drugs (2016) 14: 213-0 [P, NA] |
| Kasheverov,I.E., Chugunov,A.O., Kudryavtsev,D.S., Ivanov,I.A., Zhmak,M.N., Shelukhina,I.V., Spirova,E.N., Tabakmakher,V.M., Zelepuga,E.A., Efremov,R.G. and Tsetlin,V.I. High-Affinity α-Conotoxin PnIA Analogs Designed on the Basis of the Protein Surface Topography Method. Sci Rep (2016) 6: 36848-0 [P, NA] |
| Kwon,S., Bosmans,F., Kaas,Q., Cheneval,O., Conibear,A.C., Rosengren,K.J., Wang,C.K., Schroeder,C.I. and Craik,D.J. Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide. Biotechnol. Bioeng. (2016) 113: 2202-2212 [P, NA] |
| Lebbe,E.K., Ghequire,M.G., Peigneur,S., Mille,B.G., Devi,P., Ravichandran,S., Waelkens,E., D Souza,L., De Mot,R. and Tytgat,J. Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp. Mar Drugs (2016) 14 [P, NA] |
| Lin,B., Xiang,S., and Li,M. Residues Responsible for the Selectivity of α-Conotoxins for Ac-AChBP or nAChRs. Marine drugs (2016) 14: 173-0 [P, NA] |
| Lin,B., Xu,M., Zhu,X., Wu,Y., Liu,X., Zhangsun,D., Hu,Y., Xiang,S.H., Kasheverov,I.E., Tsetlin,V.I., Wang,X. and Luo,S. From crystal structure of α-conotoxin GIC in complex with Ac-AChBP to molecular determinants of its high selectivity for α3β2 nAChR. Sci Rep (2016) 6: 22349-0 [P, NA] |
| Menting,J.G., Gajewiak,J., MacRaild,C.A., Chou,D.H., Disotuar,M.M., Smith,N.A., Miller,C., Erchegyi,J., Rivier,J.E., Olivera,B.M., Forbes,B.E., Smith,B.J., Norton,R.S., Safavi-Hemami,H. and Lawrence,M.C. A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin. Nat. Struct. Mol. Biol. (2016) 23: 916-920 [P, NA] |
| Peng,C., Yao,G., Gao,B.M., Fan,C.X., Bian,C., Wang,J., Cao,Y., Wen,B., Zhu,Y., Ruan,Z., Zhao,X., You,X., Bai,J., Li,J., Lin,Z., Zou,S., Zhang,X., Qiu,Y., Chen,J., Coon,S.L., Yang,J. and Shi,Q. High-throughput identification of novel conotoxins from the Chinese tubular cone snail (Conus betulinus) by multi-transcriptome sequencing. Gigascience (2016) 5: 17-0 [P, NA] |
| Prashanth,J.R., Dutertre,S., Jin,A.H., Lavergne,V., Hamilton,B., Cardoso,F.C., Griffin,J., Venter,D.J., Alewood,P.F. and Lewis,R.J. The role of defensive ecological interactions in the evolution of conotoxins. Mol. Ecol. (2016) 25: 598-615 [P, NA] |
| Robinson,S.D., Chhabra,S., Belgi,A., Chittoor,B., Safavi-Hemami,H., Robinson,A.J., Papenfuss,A.T., Purcell,A.W. and Norton,R.S. A Naturally Occurring Peptide with an Elementary Single Disulfide-Directed β-Hairpin Fold. Structure (2016) 24: 293-299 [P, NA] |
| Wang,F., Yan,Z., Liu,Z., Wang,S., Wu,Q., Yu,S., Ding,J. and Dai,Q. Molecular basis of toxicity of N-type calcium channel inhibitor MVIIA. Neuropharmacology (2016) 101: 137-145 [P, NA] |
| Yuan,Y., Balsara,R.D., Zajicek,J., Kunda,S. and Castellino,F.J. Discerning the Role of the Hydroxyproline Residue in the Structure of Conantokin Rl-B and Its Role in GluN2B Subunit-Selective Antagonistic Activity toward N-Methyl-d-Aspartate Receptors. Biochemistry (2016) 55: 7112-7122 [P, NA] |
| Zhu,X., Bi,J., Yu,J., Li,X., Zhang,Y., Zhangsun,D. and Luo,S. Recombinant Expression and Characterization of α-Conotoxin LvIA in Escherichia coli. Mar Drugs (2016) 14 [P, NA] |
2015 Akcan,M., Clark,R.J., Daly,N.L., Conibear,A.C., de Faoite,A., Heghinian,M.D., Sahil,T., Adams,D.J., Marí,F. and Craik,D.J. Transforming conotoxins into cyclotides: Backbone cyclization of P-superfamily conotoxins. Biopolymers (2015) 104: 682-692 [P, NA] |
| Aman,J.W., Imperial,J.S., Ueberheide,B., Zhang,M.M., Aguilar,M., Taylor,D., Watkins,M., Yoshikami,D., Showers-Corneli,P., Safavi-Hemami,H., Biggs,J. and Olivera,B.M. Insights into the origins of fish hunting in venomous cone snails from studies of Conus tessulatus. Proc. Natl. Acad. Sci. U.S.A. (2015) 112: 5087-5092 [P, NA] |
| Aman,J.W., Imperial,J.S., Ueberheide,B., Zhang,M.M., Aguilar,M., Taylor,D., Watkins,M., Yoshikami,D., Showers-Corneli,P., Safavi-Hemami,H., Biggs,J., Teichert,R.W. and Olivera,B.M. Insights into the origins of fish hunting in venomous cone snails from studies of Conus tessulatus. Proc. Natl. Acad. Sci. U.S.A. (2015) 112: 5087-5092 [P, NA] |
| Christensen,S.B., Bandyopadhyay,P.K., Olivera,B.M. and McIntosh,J.M. αS-conotoxin GVIIIB potently and selectively blocks α9α10 nicotinic acetylcholine receptors Biochem. Pharmacol. (2015) 96: 349-356 [P, NA] |
| Deuis,J.R., Whately,E., Brust,A., Inserra,M.C., Asvadi,N.H., Lewis,R.J., Alewood,P.F., Cabot,P.J., and Vetter,I. Activation of κ opioid receptors in cutaneous nerve endings by conorphin-1, a novel subtype-selective conopeptide, does not mediate peripheral analgesia ACS Chemical Neuroscience (2015) 6: 1751-1758 [P, NA] |
| Himaya, S.W.A., Jin, A.H., Dutertre, S., Giacomotto, J., Mohialdeen, H., Vetter, I., Alewood, P.F. and Lewis, R.J. Comparative venomics reveals the complex prey capture strategy of the piscivorous cone snail Conus catus. Journal of proteome research (2015) 14: 4372-4381 [P, NA] |
| Jin,A.H., Israel,M.R., Inserra,M.C., Smith,J.J., Lewis,R.J., Alewood,P.F., Vetter,I. and Dutertre,S. δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails. Proc. Biol. Sci. (2015) 282 [P, NA] |
| Jin,A.H., Vetter,I., Himaya,S.W., Alewood,P.F., Lewis,R.J. and Dutertre,S. Transcriptome and proteome of Conus planorbis identify the nicotinic receptors as primary target for the defensive venom Proteomics (2015) 15: 4030-4040 [P, NA] |
| Kaas,Q. and Craik,D.J. Bioinformatics-Aided Venomics. Toxins (Basel) (2015) 7: 2159-2187 [P, NA] |
| Kancherla,A.K., Meesala,S., Jorwal,P., Palanisamy,R., Sikdar,S.K. and Sarma,S.P. A Disulfide Stabilized β-Sandwich Defines the Structure of a New Cysteine Framework M-Superfamily Conotoxin. ACS Chem. Biol. (2015) 10: 1847-1860 [P, NA] |
| Kompella,S.N., Cuny,H., Hung,A. and Adams,D.J. Molecular Basis for Differential Sensitivity of α-Conotoxin RegIIA at Rat and Human Neuronal Nicotinic Acetylcholine Receptors Mol. Pharmacol. (2015) 88: 993-1001 [P, NA] |
| Kompella,S.N., Hung,A., Clark,R.J., Marí,F. and Adams,D.J. Alanine scan of α-conotoxin RegIIA reveals a selective α3β4 nicotinic acetylcholine receptor antagonist J. Biol. Chem. (2015) 290: 1039-1048 [P, NA] |
| Kunda,S., Yuan,Y., Balsara,R.D., Zajicek,J. and Castellino,F.J. Hydroxyproline-induced Helical Disruption in Conantokin Rl-B Affects Subunit-selective Antagonistic Activities toward Ion Channels of N-Methyl-d-aspartate Receptors. J. Biol. Chem. (2015) 290: 18156-18172 [P, NA] |
| Li,L., Liu,N., Ding,R., Wang,S., Liu,Z., Li,H., Zheng,X. and Dai,Q. A novel 4/6-type alpha-conotoxin ViIA selectively inhibits nAchR α3β2 subtype. Acta Biochim. Biophys. Sin. (Shanghai) (2015) 47: 1023-1028 [P, NA] |
| Luo,S., Zhangsun,D., Harvey,P.J., Kaas,Q., Wu,Y., Zhu,X., Hu,Y., Li,X., Tsetlin,V.I., Christensen,S., Romero,H.K., McIntyre,M., Dowell,C., Baxter,J.C., Elmslie,K.S., Craik,D.J. and McIntosh,J.M. Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist. Proc. Natl. Acad. Sci. U.S.A. (2015) 112 [P, NA] |
| Mueller,A., Starobova,H., Inserra,M.C., Jin,A.H., Deuis,J.R., Dutertre,S., Lewis,R.J., Alewood,P.F., Daly,N.L. and Vetter,I. α-Conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors. Biochem. Pharmacol. (2015) 94: 155-163 [P, NA] |
| Rajesh,R.P. Novel M-Superfamily and T-Superfamily conotoxins and contryphans from the vermivorous snail Conus figulinus. J. Pept. Sci. (2015) 21: 29-39 [P, NA] |
| Ren,Z., Wang,L., Qin,M., You,Y., Pan,W., Zhou,L., Sun,D. and Xu,A. Pharmacological characterization of conotoxin lt14a as a potent non-addictive analgesic. Toxicon (2015) 96: 57-67 [P, NA] |
| Robinson,S.D., Safavi-Hemami,H., Raghuraman,S., Imperial,J.S., Papenfuss,A.T., Teichert,R.W., Purcell,A.W., Olivera,B.M. and Norton,R.S. Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom. J Proteomics (2015) 114: 38-47 [P, NA] |
| Safavi-Hemami,H., Gajewiak,J., Karanth,S., Robinson,S.D., Ueberheide,B., Douglass,A.D., Schlegel,A., Imperial,J.S., Watkins,M., Bandyopadhyay,P.K., Yandell,M., Li,Q., Purcell,A.W., Norton,R.S., Ellgaard,L. and Olivera,B.M. Specialized insulin is used for chemical warfare by fish-hunting cone snails. Proc. Natl. Acad. Sci. U.S.A. (2015) 112: 1743-1748 [P, NA] |
| Wan, J., Huang, J.X., Vetter, I., Mobli, M., Lawson, J., Tae, H.S., Abraham, N., Paul, B., Cooper, M.A., Adams, D.J. and Lewis, R.J. α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors Journal of the American Chemical Society (2015) 137: 3209-3212 [P, NA] |
| Wang, S., Zhao, C., Liu, Z., Wang, X., Liu, N., Du, W. and Dai, Q. Structural and functional characterization of a novel α-conotoxin Mr1. 7 from Conus marmoreus targeting neuronal nAChR α3β2, α9α10 and α6/α3β2β3 subtypes Marine drugs (2015) 13: 3259-3275 [P, NA] |
| Wilson,M.J., Zhang,M.M., Gajewiak,J., Azam,L., Rivier,J.E., Olivera,B.M. and Yoshikami,D. α- and β-subunit composition of voltage-gated sodium channels investigated with μ-conotoxins and the recently discovered μO§-conotoxin GVIIJ. J Neurophysiol (2015) 113: 2289-2301 [P, NA] |
| Xu,S., Zhang,T., Kompella,S.N., Yan,M., Lu,A., Wang,Y., Shao,X., Chi,C., Adams,D.J., Ding,J. and Wang,C. Conotoxin αD-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors. Sci Rep (2015) 5: 14261-0 [P, NA] |
| Yu,R., Seymour,V.A., Berecki,G., Jia,X., Akcan,M., Adams,D.J., Kaas,Q. and Craik,D.J. Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1. Sci Rep (2015) 5: 13264-0 [P, NA] |
| Zhang,M.M., Gajewiak,J., Azam,L., Bulaj,G., Olivera,B.M. and Yoshikami,D. Probing the Redox States of Sodium Channel Cysteines at the Binding Site of μO§-Conotoxin GVIIJ. Biochemistry (2015) 54: 3911-3920 [P, NA] |
| Zhou,M., Wang,L., Wu,Y., Liu,J., Sun,D., Zhu,X., Feng,Y., Qin,M., Chen,S. and Xu,A. Soluble expression and sodium channel activity of lt16a, a novel framework XVI conotoxin from the M-superfamily. Toxicon (2015) 98: 5-11 [P, NA] |
2014 Banerjee,J., Yongye,A.B., Chang,Y.P., Gyanda,R., Medina-Franco,J.L. and Armishaw,C.J. Design and synthesis of alpha-conotoxin GID analogues as selective alpha4beta2 nicotinic acetylcholine receptor antagonists. Biopolymers (2014) 102: 78-87 [P, NA] |
| Berecki,G., Daly,N.L., Huang,Y.H., Vink,S., Craik,D.J., Alewood,P.F. and Adams,D.J. Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Cav 2.2 channels British journal of pharmacology (2014) 171: 3313-3327 [P, NA] |
| Chen,L., Dürr,K.L. and Gouaux,E. X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism. Science (2014) 345: 1021-1026 [P, NA] |
| Chen,S., Gopalakrishnan,R., Schaer,T., Marger,F., Hovius,R., Bertrand,D., Pojer,F. and Heinis,C. Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides Nat Chem (2014) 6: 1009-1016 [P, NA] |
| Chhabra,S., Belgi,A., Bartels,P., van Lierop,B.J., Robinson,S.D., Kompella,S.N., Hung,A., Callaghan,B.P., Adams,D.J., Robinson,A.J. and Norton,R.S. Dicarba analogues of α-conotoxin RgIA. Structure, stability, and activity at potential pain targets. J. Med. Chem. (2014) 57: 9933-9944 [P, NA] |
| Dudel,J. α-Conotoxin M1 (CTx) blocks αδ binding sites of adult nicotinic receptors while ACh binding at αε sites elicits only small and short quantal synaptic currents. Physiol Rep (2014) 2 [P, NA] |
| Dutertre,S., Jin,A.H., Vetter,I., Hamilton,B., Sunagar,K., Lavergne,V., Dutertre,V., Fry,B.G., Antunes,A., Venter,D.J., Alewood,P.F. and Lewis,R.J. Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails Nat Commun (2014) 5: 3521- [P, NA] |
| Gajewiak,J., Azam,L., Imperial,J., Walewska,A., Green,B.R., Bandyopadhyay,P.K., Raghuraman,S., Ueberheide,B., Bern,M., Zhou,H.M., Minassian,N.A., Hagan,R.H., Flinspach,M., Liu,Y., Bulaj,G., Wickenden,A.D., Olivera,B.M., Yoshikami,D. and Zhang,M.M. A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ. Proc. Natl. Acad. Sci. U.S.A. (2014) 111: 2758-2763 [P, NA] |
| Green,B.R., Zhang,M.M., Chhabra,S., Robinson,S.D., Wilson,M.J., Redding,A., Olivera,B.M., Yoshikami,D., Bulaj,G. and Norton,R.S. Interactions of disulfide-deficient selenocysteine analogs of μ-conotoxin BuIIIB with the α-subunit of the voltage-gated sodium channel subtype 1.3. FEBS J. (2014) 281: 2885-2898 [P, NA] |
| Jia,X., Kwon,S., Wang,C.I., Huang,Y.H., Chan,L.Y., Tan,C.C., Rosengren,K.J., Mulvenna,J.P., Schroeder,C.I. and Craik,D.J. Semienzymatic cyclization of disulfide-rich peptides using Sortase A. J. Biol. Chem. (2014) 289: 6627-6638 [P, NA] |
| Jin,A.H., Vetter,I., Dutertre,S., Abraham,N., Emidio,N.B., Inserra,M., Murali,S.S., Christie,M.J., Alewood,P.F. and Lewis,R.J. MrIC, a Novel α-Conotoxin Agonist in the Presence of PNU at Endogenous α7 Nicotinic Acetylcholine Receptors. Biochemistry (2014) 53: 1-3 [P, NA] |
| Lebbe,E.K., Peigneur,S., Maiti,M., Devi,P., Ravichandran,S., Lescrinier,E., Ulens,C., Waelkens,E., D'Souza,L. and Tytgat,J. Structure-Function Elucidation of a New α-Conotoxin, Lo1a, from Conus longurionis. J. Biol. Chem. (2014) 289: 9573-9583 [P, NA] |
| Lebbe,E.K., Peigneur,S., Maiti,M., Mille,B.G., Devi,P., Ravichandran,S., Lescrinier,E., Waelkens,E., D'Souza,L. and Tytgat,J. Discovery of a new subclass of α-conotoxins in the venom of Conus australis. Toxicon (2014) 91: 145-154 [P, NA] |
| Lu,A., Yang,L., Xu, S. and Wang,C. Various conotoxin diversifications revealed by a venomic study of Conus flavidus. Mol. Cell Proteomics (2014) 13: 105-118 [P, NA] |
| Luo,S., Zhangsun,D., Schroeder,C.I., Zhu,X., Hu,Y., Wu,Y., Weltzin,M.M., Eberhard,S., Kaas,Q., Craik,D.J., McIntosh,J.M. and Whiteaker,P. A novel α4/7-conotoxin LvIA from Conus lividus that selectively blocks α3β2 vs. α6/α3β2β3 nicotinic acetylcholine receptors. FASEB J. (2014) 28: 1842-1853 [P, NA] |
| Nepravishta,R., Mandaliti,W., Melino,S., Eliseo,T. and Paci,M. Structure of the cyclic peptide [W8S]contryphan Vn: effect of the tryptophan/serine substitution on trans-cis proline isomerization. Amino Acids (2014) 46: 2841-2853 [P, NA] |
| Nguyen,B., Le Caer,J.P., Aráoz,R., Thai,R., Lamthanh,H., Benoit,E. and Molgó,J. Isolation, purification and functional characterization of alpha-BnIA from Conus bandanus venom. Toxicon (2014) 91: 155-163 [P, NA] |
| Platt,R.J., Curtice,K.J., Twede,V.D., Watkins,M., Gruszczyński,P., Bulaj,G., Horvath,M.P., and Olivera,B.M. From molecular phylogeny towards differentiating pharmacology for NMDA receptor subtypes. Toxicon (2014) 81: 67-79 [P, NA] |
| Puillandre,N., Bouchet,P., Duda,T.F. Jr., Kauferstein,S., Kohn,A.J., Olivera,B.M., Watkins,M. and Meyer,C. Molecular phylogeny and evolution of the cone snails (Gastropoda, Conoidea) Mol. Phylogenet. Evol. (2014) 78: 290-303 [P, NA] |
| Puillandre,N., Stöcklin,R., Favreau,P., Bianchi,E., Perret,F., Rivasseau,A., Limpalaër,L. and Bouchet,P. When everything converges: integrative taxonomy with shell, DNA and venomic data reveals Conus conco, a new species of cone snails (Gastropoda: Conoidea). Mol. Phylogenet. Evol. (2014) 80: 186-192 [P, NA] |
| Robinson,S.D. and Norton,R.S. Conotoxin gene superfamilies. Mar Drugs (2014) 12: 6058-6101 [P, NA] |
| Robinson,S.D., Safavi-Hemami,H., McIntosh,L.D., Purcell,A.W., Norton,R.S. and Papenfuss,A.T. Diversity of Conotoxin Gene Superfamilies in the Venomous Snail, Conus victoriae. PLoS ONE (2014) 9 [P, NA] |
| Stock,P., Ljaschenko,D., Heckmann,M. and Dudel,J. Agonists binding nicotinic receptors elicit specific channel-opening patterns at αγ and αδ sites. J. Physiol. (Lond.) (2014) 592: 2501-2517 [P, NA] |
| Wang,C.K., King,G.J., Northfield,S.E., Ojeda,P.G. and Craik,D.J. Racemic and quasi-racemic X-ray structures of cyclic disulfide-rich peptide drug scaffolds. Angew. Chem. Int. Ed. Engl. (2014) 53: 11236-11241 [P, NA] |
| Wang,S., Du,T., Liu,Z., Wang,S., Wu,Y., Ding,J., Jiang,L. and Dai,Q. Characterization of a T-superfamily conotoxin TxVC from Conus textile that selectively targets neuronal nAChR subtypes. Biochem. Biophys. Res. Commun. (2014) 454: 151-156 [P, NA] |
| Wu,Y., Wu,X., Yu,J., Zhu,X., Zhangsun,D. and Luo,S. Influence of disulfide connectivity on structure and bioactivity of α-conotoxin TxIA Molecules (2014) 19: 966-979 [P, NA] |
2013 Aguilar,M.B., Ortiz,E., Kaas,Q., López-Vera,E., Becerril,B., Possani,L.D. and de la Cotera,E.P. Precursor De13.1 from Conus delessertii defines the novel G gene superfamily. Peptides (2013) 41: 17-20 [P, NA] |
| Aguilar,M.B., Zugasti-Cruz,A., Falcón,A., Batista,C.V., Olivera,B.M. and Heimer de la Cotera,E.P. A novel arrangement of Cys residues in a paralytic peptide of Conus cancellatus (jr. syn.: Conus austini), a worm-hunting snail from the Gulf of Mexico. Peptides (2013) 41: 38-44 [P, NA] |
| Akcan,M., Cao,Y., Chongxu,F. and Craik,D.J. The three-dimensional solution structure of mini-M conotoxin BtIIIA reveals a disconnection between disulfide connectivity and peptide fold. Bioorg. Med. Chem. (2013) 21: 3590-3596 [P, NA] |
| Bernáldez,J., Román-González,S.A., Martínez,O., Jiménez,S., Vivas,O., Arenas,I., Corzo,G., Arreguín,R., García,D.E., Possani,L.D. and Licea,A. A Conus regularis Conotoxin with a Novel Eight-Cysteine Framework Inhibits CaV2.2 Channels and Displays an Anti-Nociceptive Activity. Mar Drugs (2013) 11: 1188-1202 [P, NA] |
| Braga,M.C., Nery,A.A., Ulrich,H., Konno,K. and Pimenta,D.C. α -RgIB: A Novel Antagonist Peptide of Neuronal Acetylcholine Receptor Isolated from Conus regius Venom. Int J Pept (2013) 2013: 543028- [P, NA] |
| Dutertre,S., Jin,A.H., Kaas,Q., Jones,A., Alewood,P.F. and Lewis,R.J. Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. Mol. Cell Proteomics (2013) 12: 312-329 [P, NA] |
| Gao,B., Zhangsun,D., Wu,Y., Lin,B., Zhu,X. and Luo,S. Expression, renaturation and biological activity of recombinant conotoxin GeXIVAWT. Appl. Microbiol. Biotechnol. (2013) 97: 1223-1230 [P, NA] |
| Grishin,A.A., Cuny,H., Hung,A., Clark,R.J., Brust,A., Akondi,K., Alewood,P.F., Craik,D.J. and Adams,D.J. Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors. J. Biol. Chem. (2013) 288: 34428-34442 [P, NA] |
| Hocking,H.G., Gerwig,G.J., Dutertre,S., Violette,A., Favreau,P., Stöcklin,R., Kamerling,J.P. and Boelens,R. Structure of the O-glycosylated conopeptide CcTx from Conus consors venom. Chemistry (2013) 19: 870-879 [P, NA] |
| Hone,A.J., Ruiz,M., Scadden,M., Christensen,S., Gajewiak,J., Azam,L. and McIntosh,J.M. Positional scanning mutagenesis of α-conotoxin PeIA identifies critical residues that confer potency and selectivity for α6/α3β2β3 and α3β2 nicotinic acetylcholine receptors. J. Biol. Chem. (2013) 288: 25428-25439 [P, NA] |
| Inserra,M.C., Kompella,S.N., Vetter,I., Brust,A., Daly,N.L., Cuny,H., Craik,D.J., Alewood,P.F., Adams,D.J. and Lewis,R.J. Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors. Biochem. Pharmacol. (2013) 86: 791-799 [P, NA] |
| Jin,A.H., Dutertre,S., Kaas,Q., Lavergne,V., Kubala,P. and Alewood,P.F. Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity. Mol. Cell Proteomics (2013) 12: 3824-3833 [P, NA] |
| Kapono,C.A., Thapa,P., Cabalteja,C.C., Guendisch,D., Collier,A.C. and Bingham,J.P. Conotoxin truncation as a post-translational modification to increase the pharmacological diversity within the milked venom of Conus magus. Toxicon (2013) [P, NA] |
| Kuang,Z., Zhang,M.M., Gupta,K., Gajewiak,J., Gulyas,J., Balaram,P., Rivier,J.E., Olivera,B.M., Yoshikami,D., Bulaj,G. and Norton,R.S. Mammalian neuronal sodium channel blocker μ-conotoxin BuIIIB has a structured N-terminus that influences potency. ACS Chem. Biol. (2013) 8: 1344-1351 [P, NA] |
| Lavergne,V., Dutertre,S., Jin,A.H., Lewis,R.J., Taft,R.J. and Alewood,P.F. Systematic interrogation of the Conus marmoreus venom duct transcriptome with ConoSorter reveals 158 novel conotoxins and 13 new gene superfamilies BMC Genomics (2013) 14: 708- [P, NA] |
| Luo,S., Christensen,S., Zhangsun,D., Wu,Y., Hu,Y., Zhu,X., Chhabra,S., Norton,R.S. and McIntosh,J.M. A novel inhibitor of α9α10 nicotinic acetylcholine receptors from Conus vexillum delineates a new conotoxin superfamily. PLoS ONE (2013) 8 [P, NA] |
| Luo,S., Zhangsun,D., Wu,Y., Zhu,X., Hu,Y., McIntyre,M., Christensen,S., Akcan,M., Craik,D.J. and McIntosh,J.M. Characterization of a novel α-conotoxin from conus textile that selectively targets α6/α3β2β3 nicotinic acetylcholine receptors. J. Biol. Chem. (2013) 288: 894-902 [P, NA] |
| Luo,S., Zhangsun,D., Zhu,X., Wu,Y., Hu,Y., Christensen,S., Harvey,P.J., Akcan,M., Craik,D.J. and McIntosh,J.M. Characterization of a novel α-conotoxin TxID from Conus textile that potently blocks rat α3β4 nicotinic acetylcholine receptors. J. Med. Chem. (2013) 56: 9655-9663 [P, NA] |
| McDougal,O.M., Granum,D.M., Swartz,M., Rohleder,C. and Maupin,C.M. pKa determination of histidine residues in α-conotoxin MII peptides by 1H NMR and constant pH molecular dynamics simulation. J Phys Chem B (2013) 117: 2653-2661 [P, NA] |
| Peigneur,S., Van Der Haegen,A., Möller,C., Waelkens,E., Diego-García,E., Marí,F., Naudé,R. and Tytgat,J. Unraveling the peptidome of the South African cone snails Conus pictus and Conus natalis. Peptides (2013) 41: 8-16 [P, NA] |
| Petrel,C., Hocking,H.G., Reynaud,M., Upert,G., Favreau,P., Biass,D., Paolini-Bertrand,M., Peigneur,S., Tytgat,J., Gilles,N., Hartley,O., Boelens,R., Stocklin,R. and Servent,D. Identification, structural and pharmacological characterization of Ï„-CnVA, a conopeptide that selectively interacts with somatostatin sst3 receptor. Biochem. Pharmacol. (2013) [P, NA] |
| Quinton,L., Servent,D., Girard,E., Molgó,J., Le Caer,J.P., Malosse,C., Haidar,E.A., Lecoq,A., Gilles,N. and Chamot-Rooke,J. Identification and functional characterization of a novel α-conotoxin (EIIA) from Conus ermineus. Anal Bioanal Chem (2013) [P, NA] |
| Ragnarsson,L., Wang,C.I., Andersson,A., Fajarningsih,D., Monks,T., Brust,A., Rosengren,K.J. and Lewis,R.J. Conopeptide Ï-TIA defines a new allosteric site on the extracellular surface of the α1B-adrenoceptor. J. Biol. Chem. (2013) 288: 1814-1827 [P, NA] |
| Sonti,R., Gowd,K.H., Rao,K.N., Ragothama,S., Rodriguez,A., Perez,J.J. and Balaram,P. Conformational diversity in contryphans from Conus venom: cis-trans isomerisation and aromatic/proline interactions in the 23-membered ring of a 7-residue peptide disulfide loop. Chemistry (2013) 19: 15175-15189 [P, NA] |
| van Lierop,B.J., Robinson,S.D., Kompella,S.N., Belgi,A., McArthur,J.R., Hung,A., MacRaild,C.A., Adams,D.J. and Robinson,A.J. Dicarba α-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors. ACS Chem. Biol. (2013) 8: 1815-1821 [P, NA] |
| Wu,Y., Wang,L., Zhou,M., You,Y., Zhu,X., Qiang,Y., Qin,M., Luo,S., Ren,Z. and Xu,A. Molecular evolution and diversity of Conus peptide toxins, as revealed by gene structure and intron sequence analyses. PLoS ONE (2013) 8 [P, NA] |
| Yu,R., Kompella,S.N., Adams,D.J., Craik,D.J. and Kaas,Q. Determination of the α-Conotoxin Vc1.1 Binding Site on the α9α10 Nicotinic Acetylcholine Receptor. J. Med. Chem. (2013) [P, NA] |
| Zhang,M.M., Wilson,M.J., Azam,L., Gajewiak,J., Rivier,J.E., Bulaj,G., Olivera,B.M. and Yoshikami,D. Co-expression of Na(V)β subunits alters the kinetics of inhibition of voltage-gated sodium channels by pore-blocking μ-conotoxins. Br. J. Pharmacol. (2013) 168: 1597-1610 [P, NA] |
| Zhou,M., Wang,L., Wu,Y., Zhu,X., Feng,Y., Chen,Z., Li,Y., Sun,D., Ren,Z. and Xu,A. Characterizing the evolution and functions of the M-superfamily conotoxins. Toxicon (2013) 76: 150-159 [P, NA] |
2012 Balsara,R., Li,N., Weber-Adrian,D., Huang,L. and Castellino,F.J. Opposing action of conantokin-G on synaptically and extrasynaptically-activated NMDA receptors. Neuropharmacology (2012) 62: 2227-2238 [P, NA] |
| Beissner,M., Dutertre,S., Schemm,R., Danker,T., Sporning,A., Grubmüller,H. and Nicke,A. Efficient binding of 4/7 α-conotoxins to nicotinic α4β2 receptors is prevented by Arg185 and Pro195 in the α4 subunit Mol. Pharmacol (2012) 82: 711-718 [P, NA] |
| Bhatia,S., Kil,Y.J., Ueberheide,B., Chait,B.T., Tayo,L., Cruz,L., Lu,B., Yates,J.R. 3rd. and Bern,M. Constrained de novo sequencing of conotoxins. J. Proteome Res. (2012) 11: 4191-4200 [P, NA] |
| Chang,D. and Duda,T.F. Jr. Extensive and continuous duplication facilitates rapid evolution and diversification of gene families. Mol. Biol. Evol. (2012) 29: 2019-2029 [P, NA] |
| Dobson,R., Collodoro,M., Gilles,N., Turtoi,A., De Pauw,E. and Quinton,L. Secretion and maturation of conotoxins in the venom ducts of Conus textile. Toxicon (2012) 60: 1370-1379 [P, NA] |
| Favreau P, Benoit E, Hocking HG, Carlier L, D hoedt D, Leipold E, Markgraf R, Schlumberger S, Córdova MA, Gaertner H, Paolini-Bertrand M, Hartley O, Tytgat J, Heinemann SH, Bertrand D, Boelens R, Stöcklin R, Molgó J A novel μ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors Br J Pharmacol (2012) 166: 1654-1668 [P, NA] |
| Franco,A., Kompella,S.N., Akondi,K.B., Melaun,C., Daly,N.L., Luetje,C.W., Alewood,P.F., Craik,D.J., Adams,D.J. and Marí,F. RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs. Biochem. Pharmacol. (2012) 83: 419-426 [P, NA] |
| Gowd,K.H., Han,T.S., Twede,V., Gajewiak,J., Smith,M.D., Watkins,M., Platt,R.J., Toledo,G., White,H.S., Olivera,B.M. and Bulaj,G. Conantokins derived from the Asprella clade impart conRl-B, an N-methyl d-aspartate receptor antagonist with a unique selectivity profile for NR2B subunits. Biochemistry (2012) 51: 4685-4692 [P, NA] |
| Hone,A.J., Scadden,M., Gajewiak,J., Christensen,S., Lindstrom,J. and McIntosh,J.M. α-Conotoxin PeIA[S9H,V10A,E14N] potently and selectively blocks α6β2β3 versus α6β4 nicotinic acetylcholine receptors. Mol. Pharmacol. (2012) 82: 972-982 [P, NA] |
| Hu,H., Bandyopadhyay,P.K., Olivera,B.M. and Yandell,M. Elucidation of the molecular envenomation strategy of the cone snail Conus geographus through transcriptome sequencing of its venom duct. BMC Genomics (2012) 13: 284-0 [P, NA] |
| Kaas,Q., Yu,R., Jin,A.H., Dutertre,S. and Craik,D.J. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Res (2012) 40 : 325-330 [P, NA] |
| Khoo,K.K., Gupta,K., Green,B.R., Zhang,M.M., Watkins,M., Olivera,B.M., Balaram,P., Yoshikami,D., Bulaj,G. and Norton,R.S. Distinct disulfide isomers of μ-conotoxins KIIIA and KIIIB block voltage-gated sodium channels. Biochemistry (2012) 51: 9826-9835 [P, NA] |
| Knapp,O., Nevin,S.T., Yasuda,T., Lawrence,N., Lewis,R.J. and Adams,D.J. Biophysical properties of Na(v) 1.8/Na(v) 1.2 chimeras and inhibition by μO-conotoxin MrVIB. Br. J. Pharmacol. (2012) 166: 2148-2160 [P, NA] |
| Liu,Z., Li,H., Liu,N., Wu,C., Jiang,J., Yue,J. and Dai,Q. Diversity and evolution of conotoxins in Conus virgo, Conus eburneus, Conus imperialis and Conus marmoreus from the South China Sea. Toxicon (2012) 60: 982-989 [P, NA] |
| Lluisma,A.O., Milash,B.A., Moore,B., Olivera,B.M. and Bandyopadhyay,P.K. Novel venom peptides from the cone snail Conus pulicarius discovered through next-generation sequencing of its venom duct transcriptome. Mar Genomics (2012) 5: 43-51 [P, NA] |
| Markgraf,R., Leipold,E., Schirmeyer,J., Paolini-Bertrand,M., Hartley,O. and Heinemann,S.H. Mechanism and molecular basis for the sodium channel subtype specificity of μ-conopeptide CnIIIC. Br. J. Pharmacol. (2012) 167: 576-586 [P, NA] |
| Napier,I.A., Klimis,H., Rycroft,B.K., Jin,A.H., Alewood,P.F., Motin,L., Adams,D.J. and Christie,M.J. Intrathecal α-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain. Neuropharmacology (2012) 62: 2202-2207 [P, NA] |
| Olivera,B.M., Watkins,M., Bandyopadhyay,P., Imperial,J.S., de la Cotera,E.P., Aguilar,M.B., Vera,E.L., Concepcion,G.P. and Lluisma,A. Adaptive radiation of venomous marine snail lineages and the accelerated evolution of venom peptide genes. Ann. N. Y. Acad. Sci. (2012) 1267: 61-70 [P, NA] |
| Pérez-Alvarez,A., Hernández-Vivanco,A., McIntosh,J.M. and Albillos,A. Native α6β4* nicotinic receptors control exocytosis in human chromaffin cells of the adrenal gland. FASEB J. (2012) 26: 346-354 [P, NA] |
| Platt,R.J., Han,T.S., Green,B.R., Smith,M.D., Skalicky,J., Gruszczynski,P., White,H.S., Olivera,B., Bulaj,G. and Gajewiak,J. Stapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins, peptidic antagonists of N-methyl-D-aspartic acid receptors. J. Biol. Chem. (2012) 287: 20727-20736 [P, NA] |
| Puillandre,N., Koua,D., Favreau,P., Olivera,B.M. and Stocklin,R. Molecular phylogeny, classification and evolution of conopeptides J. Mol. Evol. (2012) 74: 297-309 [P, NA] |
| Safavi-Hemami,H., Gorasia,D.G., Steiner,A.M., Williamson,N.A., Karas,J.A., Gajewiak,J., Olivera,B.M., Bulaj,G. and Purcell,A.W. Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails. J. Biol. Chem. (2012) 287: 34288-34303 [P, NA] |
| Schroeder,C.I., Adams,D., Thomas,L., Alewood,P.F. and Lewis,R.J. N- and C-terminal extensions of μ-conotoxins increase potency and selectivity for neuronal sodium channels. Biopolymers (2012) 98: 161-165 [P, NA] |
| Schroeder,C.I., Nielsen,K.J., Adams,D.A., Loughnan,M., Thomas,L., Alewood,P.F., Lewis,R.J. and Craik,D.J. Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID. Biopolymers (2012) 98: 345-356 [P, NA] |
| Steiner,A.M., Woycechowsky,K.J., Olivera,B.M. and Bulaj,G. Reagentless oxidative folding of disulfide-rich peptides catalyzed by an intramolecular diselenide. Angew. Chem. Int. Ed. Engl. (2012) 51: 5580-5584 [P, NA] |
| Terrat,Y., Biass,D., Dutertre,S., Favreau,P., Remm,M., Stöcklin,R., Piquemal,D. and Ducancel,F. High-resolution picture of a venom gland transcriptome: case study with the marine snail Conus consors. Toxicon (2012) 59: 34-46 [P, NA] |
| Tietze,A.A., Tietze,D., Ohlenschläger,O., Leipold,E., Ullrich,F., Kühl,T., Mischo,A., Buntkowsky,G., Görlach,M., Heinemann,S.H. and Imhof,D. Structurally diverse μ-conotoxin PIIIA isomers block sodium channel NaV 1.4. Angew. Chem. Int. Ed. Engl. (2012) 51: 4058-4061 [P, NA] |
| Van Der Haegen A, Peigneur S, Dyubankova N, Möller C, Marí F, Diego-García E, Naudé R, Lescrinier E, Herdewijn P, Tytgat J Pc16a, the first characterized peptide from Conus pictus venom, shows a novel disulfide connectivity Peptides (2012) 34: 106-113 [P, NA] |
| Vetter,I., Dekan,Z., Knapp,O., Adams,D.J., Alewood,P.F. and Lewis,R.J. Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels. Biochem. Pharmacol. (2012) 84: 540-548 [P, NA] |
| Violette,A., Biass,D., Dutertre,S., Koua,D., Piquemal,D., Pierrat,F. and Favreau,P. Large-scale discovery of conopeptides and conoproteins in the injectable venom of a fish-hunting cone snail using a combined proteomic and transcriptomic approach. J Proteomics (2012) 75: 5215-5225 [P, NA] |
| Violette,A., Leonardi,A., Piquemal,D., Terrat,Y., Biass,D., Dutertre,S., Noguier,F., Ducancel,F., Stöcklin,R., Križaj,I. and Favreau,P. Recruitment of glycosyl hydrolase proteins in a cone snail venomous arsenal: further insights into biomolecular features of Conus venoms. Mar Drugs (2012) 10: 258-280 [P, NA] |
| Ye,M., Khoo,K.K., Xu,S., Zhou,M., Boonyalai,N., Perugini,M.A., Chi,C., Galea,C.A., Wang,C. and Norton,R.S. A Helical Conotoxin From Conus Imperialis Has A Novel Cysteine Framework And Defiines A New Superfamily J Biol Chem (2012) 287: 14973-14983 [P, NA] |
| Yu,R., Kaas,Q. and Craik,D.J. Delineation of the unbinding pathway of α-conotoxin ImI from the α7 nicotinic acetylcholine receptor. J Phys Chem B (2012) 116: 6097-6105 [P, NA] |
| Zhang,B., Huang,F. and Du,W. Solution structure of a novel α-conotoxin with a distinctive loop spacing pattern. Amino Acids (2012) 43: 389-396 [P, NA] |
2011 Armishaw,C.J., Jensen,A.A., Balle,L.D., Scott,K.C., Sørensen,L. and Strømgaard,K. Improving the stability of α-conotoxin AuIB through N-to-C cyclization: the effect of linker length on stability and activity at nicotinic acetylcholine receptors. Antioxid. Redox Signal. (2011) 14: 65-76 [P, NA] |
| Bernaldez,J., López,O., Licea,A., Salceda,E., Arellano,R.O., Vega,R. and Soto,E. Electrophysiological characterization of a novel small peptide from the venom of Conus californicus that targets voltage-gated neuronal Ca2+ channels. Toxicon (2011) 57: 60-67 [P, NA] |
| Bruce,C., Fitches,E.C., Chougule,N., Bell,H.A. and Gatehouse,J.A. Recombinant conotoxin, TxVIA, produced in yeast has insecticidal activity. Toxicon (2011) 58: 93-100 [P, NA] |
| Daly,N.L., Callaghan,B., Clark,R.J., Nevin,S.T., Adams,D.J. and Craik,D.J. Structure and activity of alpha-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABA(B) receptor-coupled N-type calcium channels. J. Biol. Chem. (2011) 286: 10233-10237 [P, NA] |
| de Araujo,A.D., Callaghan,B., Nevin,S.T., Daly,N.L., Craik,D.J., Moretta,M., Hopping,G., Christie,M.J., Adams,D.J. and Alewood,P.F. Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding. Angew. Chem. Int. Ed. Engl. (2011) 50: 6527-6529 [P, NA] |
| Dekan,Z., Vetter,I., Daly,N.L., Craik,D.J., Lewis,R.J. and Alewood,P.F. α-Conotoxin ImI incorporating stable cystathionine bridges maintains full potency and identical three-dimensional structure J. Am. Chem. Soc. (2011) 133: 15866-15869 [P, NA] |
| Elliger,C.A., Richmond,T.A., Lebaric,Z.N., Pierce,N.T., Sweedler,J.V. and Gilly,W.F. Diversity of conotoxin types from Conus californicus reflects a diversity of prey types and a novel evolutionary history. Toxicon (2011) 57: 311-322 [P, NA] |
| Gilly,W.F., Richmond,T.A., Duda,T.F., Elliger,C., Lebaric,Z., Schulz,J., Bingham,J.P. and Sweedler,J.V. A diverse family of novel peptide toxins from an unusual cone snail, Conus californicus Journal of Experimental Biology (2011) 214: 147-161 [P, NA] |
| Halai,R., Callaghan,B., Daly,N.L., Clark,R.J., Adams,D.J. and Craik,D.J. Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABA(B) receptor. J. Med. Chem. (2011) 54: 6984-6992 [P, NA] |
| Hu,H., Bandyopadhyay,P.K. and Yandell,M. Characterization of the Conus bullatus genome and its venom-duct transcriptome. BMC Genomics (2011) 12: 60- [P, NA] |
| Imperial,J., Hillyard,D.R., Watkins,M., Olivera,B.M., Wagstaff,J.D., Jones,R.M., Mccabe,R.T., Cruz,L.J., Layer,R.T., Griffen,D. and Craig,A.G. Contulakin-G, Analogs Thereof and Uses Therefor Patent: JP 2011024579-A (2011) [P, NA] |
| Kauferstein,S., Porth,C., Kendel,Y., Wunder,C., Nicke,A., Kordis,D., Favreau,P., Koua,D., Stöcklin,R. and Mebs,D. Venomic study on cone snails (Conus spp.) from South Africa. Toxicon (2011) 57: 28-34 [P, NA] |
| Khoo,K.K., Wilson,M.J., Smith,B.J., Zhang,M.M., Gulyas,J., Yoshikami,D., Rivier,J.E., Bulaj,G. and Norton,R.S. Lactam-stabilized helical analogues of the analgesic μ-conotoxin KIIIA. J. Med. Chem. (2011) 54: 7558-7566 [P, NA] |
| Klimis,H., Adams,D.J., Callaghan,B., Nevin,S., Alewood,P.F., Vaughan,C.W., Mozar,C.A. and Christie,M.J. A novel mechanism of inhibition of high-voltage activated calcium channels by α-conotoxins contributes to relief of nerve injury-induced neuropathic pain. Pain (2011) 152: 259-266 [P, NA] |
| Leipold,E., Markgraf,R., Miloslavina,A., Kijas,M., Schirmeyer,J. , Imhof,D., and Heinemann,S.H Molecular determinants for the subtype specificity of μ-conotoxin SIIIA targeting neuronal voltage-gated sodium channels. Neuropharmacology (2011) 61: 105-111 [P, NA] |
| Lovelace,E.S., Gunasekera,S., Alvarmo,C., Clark,R.J., Nevin,S.T., Grishin,A.A., Adams,D.J., Craik,D.J., and Daly,N.L. Stabilization of α-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization. Antioxid. Redox Signal. (2011) 14: 87-95 [P, NA] |
| Möller,C. and Marí,F. 9.3 KDa components of the injected venom of Conus purpurascens define a new five-disulfide conotoxin framework. Biopolymers (2011) 96: 158-165 [P, NA] |
| McArthur,J.R., Singh,G., McMaster,D., Winkfein,R., Tieleman,D.P. and French,R.J. Interactions of key charged residues contributing to selective block of neuronal sodium channels by μ-conotoxin KIIIA. Mol. Pharmacol. (2011) 80: 573-584 [P, NA] |
| McArthur,J.R., Singh,G., O Mara,M.L., McMaster,D., Ostroumov,V., Tieleman,D.P. and French,R.J Orientation of µ-Conotoxin PIIIA in a Sodium Channel Vestibule, Based on Voltage Dependence of Its Binding. Mol. Pharmacol. (2011) 80: 219-227 [P, NA] |
| Pucci,L., Grazioso,G., Dallanoce,C., Rizzi,L., De Micheli,C., Clementi,F., Bertrand,S., Bertrand,D., Longhi,R., De Amici,M. and Gotti,C. Engineering of α-conotoxin MII-derived peptides with increased selectivity for native α6β2* nicotinic acetylcholine receptors. FASEB J. (2011) 25: 3775-3789 [P, NA] |
| Safavi-Hemami,H., Siero,W.A., Kuang,Z., Williamson,N.A., Karas,J.A., Page,L.R., MacMillan,D., Callaghan,B., Kompella,S.N., Adams,D.J., Norton,R.S., and Purcell,A.W. Embryonic toxin expression in the cone snail Conus victoriae: primed to kill or divergent function? J. Biol. Chem. (2011) 286: 22546-22557 [P, NA] |
| Sun,D., Ren,Z., Zeng,X., You,Y., Pan,W., Zhou,M., Wang,L. and Xu,A. Structure-function relationship of conotoxin lt14a, a potential analgesic with low cytotoxicity. Peptides (2011) 32: 300-305 [P, NA] |
| Van Der Haegen,A., Peigneur,S. and Tytgat,J. Importance of position 8 in μ-conotoxin KIIIA for voltage-gated sodium channel selectivity. FEBS J. (2011) 278: 3408-3418 [P, NA] |
| Wilson,M.J., Yoshikami,D., Azam,L., Gajewiak,J., Olivera,B.M., Bulaj,G. and Zhang,M.M. μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve. Proc. Natl. Acad. Sci. U.S.A. (2011) 108: 10302-10307 [P, NA] |
| Wilson,M.J., Zhang,M.M., Azam,L., Olivera,B.M., Bulaj,G. and Yoshikami,D. NaV β Subunits Modulate the Inhibition of NaV1.8 by the Analgesic Gating Modifier µO-Conotoxin MrVIB. J Pharmacol Exp Ther (2011) 338: 687-693 [P, NA] |
| Ye,M., Hong,J., Zhou,M., Huang,L., Shao,X., Yang,Y., Sigworth,F.J., Chi,C., Lin,D. and Wang,C. A novel conotoxin, qc16a, with a unique cysteine framework and folding. Peptides (2011) 32: 1159-1165 [P, NA] |
| Yu,R., Craik,D.J. and Kaas,Q. Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations. PLoS Comput. Biol. (2011) 7 [P, NA] |
2010 Armishaw,C.J., Singh,N., Medina-Franco,J.L., Clark,R.J., Scott,K.C., Houghten,R.A. and Jensen,A.A. A synthetic combinatorial strategy for developing alpha-conotoxin analogs as potent alpha7 nicotinic acetylcholine receptor antagonists. J. Biol. Chem. (2010) 285: 1809-1821 [P, NA] |
| Azam,L., Maskos,U., Changeux,J.P., Dowell,C.D., Christensen,S., De Biasi,M. and McIntosh,J.M. α-Conotoxin BuIA[T5A;P6O]: a novel ligand that discriminates between αβ4 and αβ2 nicotinic acetylcholine receptors and blocks nicotine-stimulated norepinephrine release. FASEB J. (2010) 24: 5113-5123 [P, NA] |
| Berecki,G., Motin,L., Haythornthwaite,A., Vink,S., Bansal,P., Drinkwater,R., Wang,C.I., Moretta,M., Lewis,R.J., Alewood,P.F. and Adams,D.J. Analgesic ω-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels. Mol Pharmacol (2010) 77: 139-148 [P, NA] |
| Biggs,J.S., Watkins,M., Puillandre,N., Ownby,J.P., Lopez-Vera,E., Christensen,S., Moreno,K.J., Bernaldez,J., Licea-Navarro,A. and Olivera,B.M. Evolution of Conus peptide toxins: analysis of Conus californicus Reeve, 1844. Mol. Phylogenet. Evol. (2010) 56: 1-12 [P, NA] |
| Callaghan,B. and Adams,D.J. Analgesic α-conotoxins Vc1.1 and RgIA inhibit N-type calcium channels in sensory neurons of α9 nicotinic receptor knockout mice. Channels (Austin) (2010) 4: 51-54 [P, NA] |
| Chen,P., Dendorfer,A., Finol-Urdaneta,R.K., Terlau,H. and Olivera,B.M. Biochemical characterization of kM-RIIIJ, a KV1.2 channel blocker: Evaluation of cardioprotective effects of kM-conotoxins. J Biol Chem (2010) 285: 14882-14889 [P, NA] |
| Clark,R.J., Jensen,J., Nevin,S.T., Callaghan,B.P. and Craik,D.J. The engineering of an orally active conotoxin for the treatment of neuropathic pain. Angew. Chem. Int. Ed. Engl. (2010) 49: 6545-6548 [P, NA] |
| Gowd,K.H., Watkins,M., Twede,V.D., Bulaj,G.W. and Olivera,B.M. Characterization of conantokin Rl-A: molecular phylogeny as structure/function study. J. Pept. Sci. (2010) 16: 375-382 [P, NA] |
| Grishin,A.A., Wang,C.I., Muttenthaler,M., Alewood,P.F., Lewis,R.J. and Adams,D.J. Alpha-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of alpha3beta4 nicotinic acetylcholine receptors. J. Biol. Chem. (2010) 285: 22254-22263 [P, NA] |
| Gupta,K. and Balaram,P. Disulfide bond assignments by mass spectrometry of native natural peptides: cysteine pairing in disulfide bonded conotoxins. Anal. Chem. (2010) 82: 8313-8319 [P, NA] |
| Jimenez,E.C. and Olivera,B.M. Divergent M- and O-superfamily peptides from venom of fish-hunting Conus parius. Peptides (2010) 31: 1678-1683 [P, NA] |
| Kaas,Q., Westermann, J. and Craik,D.J. Conopeptide characterization and classifications: an analysis using ConoServer. Toxicon (2010) 55: 1491-1509 [P, NA] |
| Lee,S., Kim,Y., Back,S.K., Choi,H.W., Lee,J.Y., Jung,H.H., Ryu,J.H., Suh,H.W., Na,H.S., Kim,H.J. and Kim,J.I. Analgesic effect of highly reversible ω-conotoxin FVIA on N type Ca2+ channels. Mol Pain (2010) 6: 97-0 [P, NA] |
| Liu,Z., Yu,Z., Liu,N., Zhao,C., Hu,J. and Dai,Q. cDNA cloning of conotoxins with framework XII from several Conus species. Acta Biochim. Biophys. Sin. (Shanghai) (2010) 42: 656-661 [P, NA] |
| Luo,S., Akondi,K.B., Zhangsun,D., Wu,Y., Zhu,X., Hu,Y., Christensen,S., Dowell,C., Daly,N.L., Craik,D.J., Wang,C.I., Lewis,R.J., Alewood,P.F. and Michael McIntosh,J. Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha3beta2 nicotinic receptor. J. Biol. Chem. (2010) 285: 12355-12366 [P, NA] |
| Möller,C., Melaun,C., Castillo,C., Díaz,M.E., Renzelman,C.M., Estrada,O., Kuch,U., Lokey,S. and Marí,F. Functional hypervariability and gene diversity of cardioactive neuropeptides. J. Biol. Chem. (2010) 285: 40673-40680 [P, NA] |
| Peng,C., Chen,W., Sanders,T., Chew,G., Liu,J., Hawrot,E. and Chi,C. Chemical synthesis and characterization of two α4/7-conotoxins. Acta Biochim. Biophys. Sin. (Shanghai) (2010) 42: 745-753 [P, NA] |
| Peng,C., Ye,M., Wang,Y., Shao,X., Yuan,D., Liu,J., Hawrot,E. and Chi,C. A new subfamily of conotoxins belonging to the A-superfamily. Peptides (2010) 31: 2009-2016 [P, NA] |
| Puillandre,N. and Olivera,B.M. Evolution of Conus Peptide Genes: Duplication and Positive Selection in the A-Superfamily. J Mol Evol (2010) [P, NA] |
| Wu,X., Shao,X., Guo,Z.Y. and Chi,C.W. Identification of neuropeptide Y-like conopeptides from the venom of Conus betulinus. Acta Biochim. Biophys. Sin. (Shanghai) (2010) 42: 502-505 [P, NA] |
| Wu,X.C., Zhou,M., Peng,C., Shao,X.X. and Chi,C.W. Novel conopeptides in a form of disulfide-crosslinked dimer. Peptides (2010) 31: 1001-1006 [P, NA] |
| Xu,J., Wang,Y., Zhang,B. and Du,W. Stereochemistry of 4-hydroxyproline affects the conformation of conopeptides. Chem. Commun. (Camb.) (2010) 46: 5467-5469 [P, NA] |
| Zhang,L., Shao,X., Chi,C. and Wang,C. Two short D-Phe-containing cysteine-free conopeptides from Conus marmoreus. Peptides (2010) 31: 177-179 [P, NA] |
2009 Aguilar,M.B., Flores-Torres,A., Batista,C.V., Falcon,A., Lopez-Vera,E. and de la Cotera,E.P. Structural characterization of five post-translationally modified isomorphs of a novel putative delta-conotoxin from the vermivorous snail Conus delessertii from the Mexican Caribbean Sea. Peptides (2009) 30: 458-466 [P, NA] |
| Armishaw,C., Jensen,A.A., Balle,T., Clark,R.J., Harpsøe,K., Skonberg,C., Liljefors,T. and Strømgaard,K. Rational design of alpha-conotoxin analogues targeting alpha7 nicotinic acetylcholine receptors: improved antagonistic activity by incorporation of proline derivatives. J. Biol. Chem. (2009) 284: 9498-9512 [P, NA] |
| Biass,D., Dutertre,S., Gerbault,A., Menou,J.L., Offord,R., Favreau,P. and Stöcklin,R. Comparative proteomic study of the venom of the piscivorous cone snail Conus consors. J Proteomics (2009) 72: 210-218 [P, NA] |
| Brust,A., Palant,E., Croker,D.E., Colless,B., Drinkwater,R., Patterson,B., Schroeder,C.I., Wilson,D., Nielsen,C.K., Smith,M.T., Alewood,D., Alewood,P.F. and Lewis,R.J. chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. J. Med. Chem. (2009) 52: 6991-7002 [P, NA] |
| Davis,J., Jones,A. and Lewis,R.J. Remarkable inter- and intra-species complexity of conotoxins revealed by LC/MS. Peptides (2009) 30: 1222-1227 [P, NA] |
| Duda,T.F. Jr. and Lee,T. Ecological release and venom evolution of a predatory marine snail at Easter Island. PLoS ONE (2009) 4 [P, NA] |
| Duda,T.F. Jr., Chang,D., Lewis,B.D. and Lee,T. Geographic variation in venom allelic composition and diets of the widespread predatory marine gastropod Conus ebraeus. PLoS ONE (2009) 4 [P, NA] |
| Halai,R., Clark,R.J., Nevin,S.T., Jensen,J.E., Adams,D.J. and Craik,D.J. Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha9alpha10 nicotinic acetylcholine receptor. J. Biol. Chem. (2009) [P, NA] |
| Han,T.S., Zhang,M.M., Walewska,A., Gruszczynski,P., Robertson,C.R., Cheatham,T.E. 3rd, Yoshikami,D., Olivera,B.M., Bulaj,G. Structurally minimized μ-conotoxin analogues as sodium channel blockers: implications for designing conopeptide-based therapeutics. ChemMedChem (2009) 4: 406-414 [P, NA] |
| Holford,M., Zhang,M.M., Gowd,K.H., Azam,L., Green,B.R., Watkins,M., Ownby,J.P., Yoshikami,D., Bulaj,G. and Olivera,B.M. Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatus. Toxicon (2009) 53: 90-98 [P, NA] |
| Hone,A.J., Whiteaker,P., Christensen,S., Xiao,Y., Meyer,E.L. and McIntosh,J.M. A novel fluorescent alpha-conotoxin for the study of alpha7 nicotinic acetylcholine receptors. J. Neurochem. (2009) 111: 80-89 [P, NA] |
| Huang,F. and Du,W. Solution Structure of Hyp10Pro variant of conomarphin, a cysteine-free and D-amino-acid containing conopeptide. Toxicon (2009) [P, NA] |
| Kasheverov,I.E., Zhmak,M.N., Fish,A., Rucktooa,P., Khruschov,A.Y., Osipov,A.V., Ziganshin,R.H., D'hoedt,D., Bertrand,D., Sixma,T.K., Smit,A.B. and Tsetlin,V.I. Interaction of alpha-conotoxin ImII and its analogs with nicotinic receptors and acetylcholine-binding proteins: additional binding sites on Torpedo receptor. J. Neurochem. (2009) 111: 934-944 [P, NA] |
| Kauferstein,S., Kendel,Y., Nicke,A., Coronas,F.I., Possani,L.D., Favreau,P., Krizaj,I., Wunder,C., Kauert,G. and Mebs,D. New conopeptides of the D-superfamily selectively inhibiting neuronal nicotinic acetylcholine receptors. Toxicon (2009) 54: 295-301 [P, NA] |
| Khoo,K.K., Feng,Z.P., Smith,B.J., Zhang,M.M., Yoshikami,D., Olivera,B.M., Bulaj,G. and Norton,R.S. Structure of the Analgesic mu-Conotoxin KIIIA and Effects on the Structure and Function of Disulfide Deletion. Biochemistry (2009) 6: 1210-1219 [P, NA] |
| Lewis RJ Conotoxins: molecular and therapeutic targets. Prog. Mol. Subcell. Biol. (2009) 46: 45-65 [P, NA] |
| Liu,Z., Xu,N., Hu,J., Zhao,C., Yu,Z. and Dai,Q. Identification of novel I-superfamily conopeptides from several clades of Conus species found in the South China Sea. Peptides (2009) 30: 1782-1787 [P, NA] |
| Loughnan,M.L., Nicke,A., Lawrence,N. and Lewis,R.J. Novel alphaD-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily. Biochemistry (2009) 48: 3717-3729 [P, NA] |
| MacRaild,C.A., Illesinghe,J., van Lierop,B.J., Townsend,A.L., Chebib,M., Livett,B.G., Robinson,A.J. and Norton,R.S. Structure and activity of (2,8)-dicarba-(3,12)-cystino alpha-ImI, an alpha-conotoxin containing a nonreducible cystine analogue. J. Med. Chem. (2009) 52: 755-762 [P, NA] |
| Millard EL, Nevin ST, Loughnan ML, Nicke A, Clark RJ, Alewood PF, Lewis RJ, Adams DJ, Craik DJ, Daly NL Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues. J Biol Chem. (2009) 284: 4944-4951 [P, NA] |
| Peng,C., Chen,W., Han,Y., Sanders,T., Chew,G., Liu,J., Hawrot,E., Chi,C. and Wang,C. Characterization of a novel alpha4/4-conotoxin, Qc1.2, from vermivorous Conus quercinus. Acta Biochim. Biophys. Sin. (Shanghai) (2009) 41: 858-864 [P, NA] |
| Quinton,L., Gilles,N. and De Pauw,E. TxXIIIA, an atypical homodimeric conotoxin found in the Conus textile venom. J Proteomics (2009) 72: 219-226 [P, NA] |
| Turner,M., Eidemiller,S., Martin,B., Narver,A., Marshall,J., Zemp,L., Cornell,K.A., McIntosh,J.M. and McDougal,O.M. Structural basis for alpha-conotoxin potency and selectivity. Bioorg. Med. Chem. (2009) 17: 5894-5899 [P, NA] |
| Twede,V.D., Miljanich,G., Olivera,B.M. and Bulaj,G. Neuroprotective and cardioprotective conopeptides: an emerging class of drug leads. Curr Opin Drug Discov Devel (2009) 12: 231-239 [P, NA] |
| Twede,V.D., Teichert,R.W., Walker,C.S., Gruszczynski,P., Kazmierkiewicz,R., Bulaj,G. and Olivera,B.M. Conantokin-Br from Conus brettinghami and selectivity determinants for the NR2D subunit of the NMDA receptor. Biochemistry (2009) 48: 4063-4073 [P, NA] |
| Ueberheide,B.M., Fenyö,D., Alewood,P.F. and Chait,B.T. Rapid sensitive analysis of cysteine rich peptide venom components. Proc. Natl. Acad. Sci. U.S.A. (2009) 106: 6910-6915 [P, NA] |
| Walker,C.S., Jensen,S., Ellison,M., Matta,J.A., Lee,W.Y., Imperial,J.S., Duclos,N., Brockie,P.J., Madsen,D.M., Isaac,J.T., Olivera,B. and Maricq,A.V. A novel Conus snail polypeptide causes excitotoxicity by blocking desensitization of AMPA receptors. Curr. Biol. (2009) 19: 900-908 [P, NA] |
| Wang,L., Liu,J., Pi,C., Zeng,X., Zhou,M., Jiang,X., Chen,S., Ren,Z. and Xu,A. Identification of a novel M-superfamily conotoxin with the ability to enhance tetrodotoxin sensitive sodium currents. Arch. Toxicol. (2009) [P, NA] |
| Yuan,D.D., Liu,L., Shao,X.X., Peng,C., Chi,C.W. and Guo,Z.Y. New conotoxins define the novel I3-superfamily. Peptides (2009) 30: 861-865 [P, NA] |
| Zamora-Bustillos,R., Aguilar,M.B. and Falcón,A. Identification, by molecular cloning, of a novel type of I(2)-superfamily conotoxin precursor and two novel I(2)-conotoxins from the worm-hunter snail Conus spurius from the Gulf of México Peptides (2009) 31: 384-393 [P, NA] |
| Zamora-Bustillos,R., Aguilar,M.B., Falcón,A. and Heimer de la Cotera,E.P. Identification, by RT-PCR, of four novel T-1-superfamily conotoxins from the vermivorous snail Conus spurius from the Gulf of Mexico. Peptides (2009) 30: 1396-1404 [P, NA] |
2008 Aguilar,M.B., Luna-RamiÂrez,K.S., Echeverria,D., Falcon,A., Olivera,B.M., Heimer de la Cotera,E.P. and Maillo,M. Conorfamide-Sr2, a gamma-carboxyglutamate-containing FMRFamide-related peptide from the venom of Conus spurius with activity in mice and mollusks. Peptides (2008) 29: 186-195 [P, NA] |
| Azam,L., Yoshikami,D., and McIntosh,J.M. Amino acid residues that confer high selectivity of the alpha6 nicotinic acetylcholine receptor subunit to alpha-conotoxin MII[S4A,E11A,L15A]. J. Biol. Chem. (2008) 283: 11625-11632 [P, NA] |
| Benoit,E., Favreau,P., Schlumberger,S., Cordova,M.A., Tytgat,J., Stocklin, R. abd and R. Stocklin and Molgo J. A new mu-conotoxin from Conus consors that atypically targets sodium channels in unmyelinated and myelinated nerve fibers Abstract Book, 16th European Section Meeting of the International Society on Toxinology (2008) [P, NA] |
| Biggs,J.S., Olivera,B.M. and Kantor,Y.I. alpha-Conopeptides specifically expressed in the salivary gland of Conus pulicarius. Toxicon (2008) 52: 101-105 [P, NA] |
| Buczek,O., Jimenez,E.C., Yoshikami,D., Imperial,J.S., Watkins,M., Morrison,A. and Olivera,B.M. I(1)-superfamily conotoxins and prediction of single D-amino acid occurrence. Toxicon (2008) 51: 218-229 [P, NA] |
| Callaghan,B., Haythornthwaite,A., Berecki,G., Clark,R.J., Craik,D.J. and Adams,D.J. Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation. J. Neurosci. (2008) 28: 10943-10951 [P, NA] |
| Chen,P., Garrett,J.E., Watkins,M. and Olivera,B.M. Purification and characterization of a novel excitatory peptide from Conus distans venom that defines a novel gene superfamily of conotoxins. Toxicon (2008) 52: 139-145 [P, NA] |
| Clark,R.J., Daly,N.L., Halai,R., Nevin,S.T., Adams,D.J. and Craik,D.J. The three-dimensional structure of the analgesic alpha-conotoxin, RgIA. FEBS Lett. (2008) 582: 597-602 [P, NA] |
| Duda,T.F. Jr. and Remigio,E.A. Variation and evolution of toxin gene expression patterns of six closely related venomous marine snails. Mol. Ecol. (2008) 17: 3018-3032 [P, NA] |
| Duda,T.F. Jr., Bolin,M.B., Meyer,C.P. and Kohn,A.J. Hidden diversity in a hyperdiverse gastropod genus: discovery of previously unidentified members of a Conus species complex. Mol. Phylogenet. Evol. (2008) 49: 867-876 [P, NA] |
| Dutertre,S., Croker,D., Daly,N.L., Andersson,A., Muttenthaler,M., Lumsden,N.G., Craik,D.J., Alewood,P.F., Guillon,G. and Lewis,R.J. Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides. J. Biol. Chem. (2008) 283: 7100-7108 [P, NA] |
| Ellison,M., Feng,Z.P., Park,A.J., Zhang,X., Olivera,B.M., McIntosh,J.M. and Norton,R.S. Alpha-RgIA, a novel conotoxin that blocks the alpha9alpha10 nAChR: structure and identification of key receptor-binding residues. J. Mol. Biol. (2008) 377: 1216-1227 [P, NA] |
| Fiedler,B., Zhang,M.M., Buczek,O., Azam,L., Bulaj,G., Norton,R.S., Olivera,B.M. and Yoshikami,D. Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7. Biochem. Pharmacol. (2008) 75: 2334-2344 [P, NA] |
| Gowd,K.H., Dewan,K.K., Iengar,P., Krishnan,K.S. and Balaram,P. Probing peptide libraries from Conus achatinus using mass spectrometry and cDNA sequencing: identification of delta and omega-conotoxins. J Mass Spectrom (2008) 43: 791-805 [P, NA] |
| Gowd,K.H., Twede,V., Watkins,M., Krishnan,K.S., Teichert,R.W., Bulaj,G. and Olivera,B.M. Conantokin-P, an unusual conantokin with a long disulfide loop. Toxicon (2008) 52: 203-213 [P, NA] |
| Han,Y., Huang,F., Jiang,H., Liu,L., Wang,Q., Wang,Y., Shao,X., Chi,C., Du,W. and Wang,C. Purification and structural characterization of a D-amino acid-containing conopeptide, conomarphin, from Conus marmoreus. FEBS J. (2008) 275: 1976-1987 [P, NA] |
| Imperial,J.S., Chen,P., Sporning,A., Terlau,H., Daly,N.L., Craik,D.J. and Olivera,B.M. Tyrosine-rich conopeptides affect voltage-gated K+ channels. J. Biol. Chem. (2008) 283: 23026-23032 [P, NA] |
| Innocent,N., Livingstone,P.D., Hone,A., Kimura,A., Young,T., Whiteaker,P., McIntosh,J.M. and Wonnacott,S. Alpha-conotoxin Arenatus IB[V11L,V16D] [corrected] is a potent and selective antagonist at rat and human native alpha7 nicotinic acetylcholine receptors. J. Pharmacol. Exp. Ther. (2008) 327: 529-537 [P, NA] |
| Kaas,Q., Westermann,J.C., Halai,R. and Craik,D.J. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24: 445-446 [P, NA] |
| Liu,L., Wu,X., Yuan,D., Chi,C. and Wang,C. Identification of a novel S-superfamily conotoxin from vermivorous Conus caracteristicus. Toxicon (2008) 51: 1331-1337 [P, NA] |
| Lluisma,A.O., López-Vera,E., Bulaj,G., Watkins,M. and Olivera,B.M. Characterization of a novel psi-conotoxin from Conus parius Reeve. Toxicon (2008) 51: 174-180 [P, NA] |
| Motin,L. and Adams,D.J. omega-Conotoxin inhibition of excitatory synaptic transmission evoked by dorsal root stimulation in rat superficial dorsal horn. Neuropharmacology (2008) 55: 860-864 [P, NA] |
| Peng,C., Han,Y., Sanders,T., Chew,G., Liu,J., Hawrot,E., Chi,C. and Wang,C. alpha4/7-conotoxin Lp1.1 is a novel antagonist of neuronal nicotinic acetylcholine receptors. Peptides (2008) 29: 1700-1707 [P, NA] |
| Peng,C., Liu,L., Shao,X., Chi,C. and Wang,C. Identification of a novel class of conotoxins defined as V-conotoxins with a unique cysteine pattern and signal peptide sequence. Peptides (2008) 29: 985-991 [P, NA] |
| Remigio,E.A. and Duda,T.F. Jr. Evolution of ecological specialization and venom of a predatory marine gastropod. Mol. Ecol. (2008) 17: 1156-1162 [P, NA] |
| Romeo,C., Di Francesco,L., Oliverio,M., Palazzo,P., Massilia,G.R., Ascenzi,P., Polticelli,F. and Schininà ,M.E. Conus ventricosus venom peptides profiling by HPLC-MS: a new insight in the intraspecific variation. J Sep Sci (2008) 31: 488-498 [P, NA] |
| Schroeder,C.I., Ekberg,J., Nielsen,K.J., Adams,D., Loughnan,M.L., Thomas,L., Adams,D.J., Alewood,P.F. and Lewis,R.J. Neuronally mu-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels. J. Biol. Chem. (2008) 283: 21621-21628 [P, NA] |
| Walewska A, Skalicky JJ, Davis DR, Zhang MM, Lopez-Vera E, Watkins M, Han TS, Yoshikami D, Olivera BM, Bulaj G NMR-based mapping of disulfide bridges in cysteine-rich peptides: application to the mu-conotoxin SxIIIA J Am Chem Soc (2008) 130: 14280-14286 [P, NA] |
| Wang,L., Pi,C., Liu,J., Chen,S., Peng,C., Sun,D., Zhou,M., Xiang,H., Ren,Z. and Xu,A. Identification and characterization of a novel O-superfamily conotoxin from Conus litteratus. J. Pept. Sci. (2008) 14: 1077-1083 [P, NA] |
| Wang,Q., Jiang,H., Han,Y.H., Yuan,D.D. and Chi,C.W. Two different groups of signal sequence in M-superfamily conotoxins. Toxicon (2008) 51: 813-822 [P, NA] |
| Wang,Y., Shao,X., Li,M., Wang,S., Chi,C. and Wang,C. mr1e, a conotoxin from Conus marmoreus with a novel disulfide pattern. Acta Biochim. Biophys. Sin. (Shanghai) (2008) 40: 391-396 [P, NA] |
| Whiteaker,P., Marks,M.J., Christensen,S., Dowell,C., Collins,A.C. and McIntosh,J.M. Synthesis and characterization of 125I-alpha-conotoxin ArIB[V11L;V16A], a selective alpha7 nicotinic acetylcholine receptor antagonist. J. Pharmacol. Exp. Ther. (2008) 325: 910-919 [P, NA] |
| Yao,S., Zhang,M.M., Yoshikami,D., Azam,L., Olivera,B.M., Bulaj,G. and Norton,R.S. Structure, dynamics, and selectivity of the sodium channel blocker mu-conotoxin SIIIA. Biochemistry (2008) 47: 10940-10949 [P, NA] |
| Yuan,D.D., Liu,L., Shao,X.X., Peng,C., Chi,C.W. and Guo,Z.Y. Isolation and cloning of a conotoxin with a novel cysteine pattern from Conus caracteristicus. Peptides (2008) 29: 1521-1525 [P, NA] |
| Zugasti-Cruz,A., Aguilar,M.B., Falcón,A., Olivera,B.M. and Heimer de la Cotera,E.P. Two new 4-Cys conotoxins (framework 14) of the vermivorous snail Conus austini from the Gulf of Mexico with activity in the central nervous system of mice. Peptides (2008) 29: 179-185 [P, NA] |
2007 Aguilar,M.B., López-Vera,E., Heimer de la Cotera,E.P., Falcón,A., Olivera,B.M. and Maillo,M. I-conotoxins in vermivorous species of the West Atlantic: peptide sr11a from Conus spurius. Peptides (2007) 28: 18-23 [P, NA] |
| Biggs,J.S., Rosenfeld,Y., Shai,Y. and Olivera,B.M. Conolysin-Mt: a conus peptide that disrupts cellular membranes. Biochemistry (2007) 46: 12586-12593 [P, NA] |
| Bordia,T., Grady,S.R., McIntosh,J.M. and Quik,M. Nigrostriatal damage preferentially decreases a subpopulation of alpha6beta2* nAChRs in mouse, monkey, and Parkinson Mol. Pharmacol. (2007) 72: 52-61 [P, NA] |
| Buczek,O., Wei,D., Babon,J.J., Yang,X., Fiedler,B., Chen,P., Yoshikami,D., Olivera,B.M., Bulaj,G. and Norton,R.S. Structure and sodium channel activity of an excitatory I1-superfamily conotoxin. Biochemistry (2007) 46: 9929-9940 [P, NA] |
| Cortez,L., Marino-Buslje,C., de Jiménez Bonino,M.B. and Hellman,U. Interactions between alpha-conotoxin MI and the Torpedo marmorata receptor alpha-delta interface. Biochem. Biophys. Res. Commun. (2007) 355: 275-279 [P, NA] |
| Du,W.H., Han,Y.H., Huang,F.J., Li,J., Chi,C.W. and Fang,W.H. Solution structure of an M-1 conotoxin with a novel disulfide linkage FEBS J. (2007) 274: 2596-2602 [P, NA] |
| Dutertre,S., Ulens,C., Büttner,R., Fish,A., van Elk,R., Kendel,Y., Hopping,G., Alewood,P.F., Schroeder,C., Nicke,A., Smit,A.B., Sixma,T.K. and Lewis,R.J. AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity. EMBO J. (2007) 26: 3858-3867 [P, NA] |
| Jimenez,E.C., Olivera,B.M. and Teichert,R.W. AlphaC-conotoxin PrXA: a new family of nicotinic acetylcholine receptor antagonists. Biochemistry (2007) 46: 8717-8724 [P, NA] |
| Jin,A.H., Brandstaetter,H., Nevin,S.T., Tan,C.C., Clark,R.J., Adams,D.J., Alewood,P.F., Craik,D.J. and Daly,N.L. Structure of alpha-conotoxin BuIA: influences of disulfide connectivity on structural dynamics. BMC Struct. Biol. (2007) 7: 28-0 [P, NA] |
| Kang,T.S., Radic,Z., Talley,T.T., Jois,S.D., Taylor,P. and Kini,R.M. Protein folding determinants: structural features determining alternative disulfide pairing in alpha- and chi/lambda-conotoxins. Biochemistry (2007) 46: 3338-3355 [P, NA] |
| Korukottu,J., Bayrhuber,M., Montaville,P., Vijayan,V., Jung,Y.S., Becker,S. and Zweckstetter,M. Fast high-resolution protein structure determination by using unassigned NMR data. Angew. Chem. Int. Ed. Engl. (2007) 46: 1176-1179 [P, NA] |
| López-Vera,E., Aguilar,M.B., Schiavon,E., Marinzi,C., Ortiz,E., Restano Cassulini,R., Batista,C.V., Possani,L.D., Heimer de la Cotera,E.P., Peri,F., Becerril,B. and Wanke,E. Novel alpha-conotoxins from Conus spurius and the alpha-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors. FEBS J. (2007) 274: 3972-3985 [P, NA] |
| López-Vera,E., Jacobsen,R.B., Ellison,M., Olivera,B.M. and Teichert,R.W. A novel alpha conotoxin (alpha-PIB) isolated from C. purpurascens is selective for skeletal muscle nicotinic acetylcholine receptors Toxicon (2007) 49: 1193-1199 [P, NA] |
| Lewis,R.J., Schroeder,C.I., Ekberg,J., Nielsen,K.J., Loughnan,M., Thomas,L., Adams,D.A., Drinkwater,R., Adams,D.J. and Alewood,P.F. Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels Mol. Pharmacol. (2007) 71: 676-685 [P, NA] |
| Liu,J., Wu,Q., Pi,C., Zhao,Y., Zhou,M., Wang,L., Chen,S. and Xu,A. Isolation and characterization of a T-superfamily conotoxin from Conus litteratus with targeting tetrodotoxin-sensitive sodium channels. Peptides (2007) 28: 2313-2319 [P, NA] |
| Liu,L., Chew,G., Hawrot,E., Chi,C. and Wang,C. Two potent alpha3/5 conotoxins from piscivorous Conus achatinus. Acta Biochim. Biophys. Sin. (Shanghai) (2007) 39: 438-444 [P, NA] |
| Luna-Ramirez,K.S., Aguilar,M.B., Falcon,A., Heimer de la Cotera,E.P., Olivera,B.M. and Maillo,M. An O-conotoxin from the vermivorous Conus spurius active on mice and mollusks Peptides (2007) 28: 24-30 [P, NA] |
| Luo,S., Zhangsun,D., Feng,J., Wu,Y., Zhu,X. and Hu,Y. Diversity of the O-superfamily conotoxins from Conus miles J. Pept. Sci. (2007) 13: 44-53 [P, NA] |
| Mandal,A.K., Ramasamy,M.R., Sabareesh,V., Openshaw,M.E., Krishnan,K.S. and Balaram,P. Sequencing of T-superfamily conotoxins from Conus virgo: pyroglutamic acid identification and disulfide arrangement by MALDI mass spectrometry. J. Am. Soc. Mass Spectrom. (2007) 18: 1396-1404 [P, NA] |
| Moller,C. and Mari,F. A vasopressin/oxytocin-related conopeptide with gamma-carboxyglutamate at position 8 Biochem. J. (2007) 404: 413-419 [P, NA] |
| Nevin,S.T., Clark,R.J., Klimis,H., Christie,M.J., Craik,D.J. and Adams,D.J. Are alpha9alpha10 nicotinic acetylcholine receptors a pain target for alpha-conotoxins? Mol. Pharmacol. (2007) 72: 1406-1410 [P, NA] |
| Peng,C., Wu,X., Han,Y., Yuan,D., Chi,C. and Wang,C. Identification of six novel T-1 conotoxins from Conus pulicarius by molecular cloning. Peptides (2007) 28: 2116-2124 [P, NA] |
| Teichert,R.W., Jacobsen,R., Terlau,H., Yoshikami,D. and Olivera,B.M. Discovery and characterization of the short kappaA-conotoxins: a novel subfamily of excitatory conotoxins Toxicon (2007) 49: 318-328 [P, NA] |
| Teichert,R.W., Jimenez,E.C., Twede,V., Watkins,M., Hollmann,M., Bulaj,G. and Olivera,B.M. Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors. J. Biol. Chem. (2007) 282: 36905-36913 [P, NA] |
| Thakur,S.S. and Balaram,P. Rapid mass spectral identification of contryphans. Detection of characteristic peptide ions by fragmentation of intact disulfide-bonded peptides in crude venom. Rapid Commun. Mass Spectrom. (2007) 21: 3420-3426 [P, NA] |
| Watkins, M., Hillyard, D.R., McIntosh, M.J., Jones, R.M. and Olivera, B.M. Alpha-conotoxin peptides Patent: EP 1852440-A 07-NOV-2007; University of Utah Research Foundation (US); (2007) [P, NA] |
| Whiteaker, P., Christensen,S., Yoshikami,D., Dowell,C., Watkins,M., Gulyas,J., Rivier,J., Olivera,B.M. and McIntosh,J.M. Discovery, Synthesis, and Structure Activity of a Highly Selective alpha7 Nicotinic Acetylcholine Receptor Antagonist Biochemistry (2007) 46: 6628-6638 [P, NA] |
| Yuan,D.D., Han,Y.H., Wang,C.G. and Chi,C.W. From the identification of gene organization of alpha conotoxins to the cloning of novel toxins Toxicon (2007) 49: 1135-1149 [P, NA] |
| Zhang,M.M., Green,B.R., Catlin,P., Fiedler,B., Azam,L., Chadwick,A., Terlau,H., McArthur,J.R., French,R.J., Gulyas,J., Rivier,J.E., Smith,B.J., Norton,R.S., Olivera,B.M., Yoshikami,D. and Bulaj,G. Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J. Biol. Chem. (2007) 282: 30699-30706 [P, NA] |
2006 Aguilar,M.B., Lezama-Monfil,L., Maillo,M., Pedraza-Lara,H., Lopez-Vera,E. and Heimer de la Cotera,E.P. A biologically active hydrophobic T-1-conotoxin from the venom of Conus spurius Peptides (2006) 27: 500-505 [P, NA] |
| Armishaw,C.J., Daly,N.L., Nevin,S.T., Adams,D.J., Craik,D.J. and Alewood,P.F. Alpha-selenoconotoxins, a new class of potent alpha7 neuronal nicotinic receptor antagonists J. Biol. Chem. (2006) 281: 14136-14143 [P, NA] |
| Bulaj,G., West,P.J., Garrett,J.E., Watkins,M., Zhang,M.-M., Norton,R.S., Smith,B.J., Yoshikami,D. and Olivera,B.M. Synthetic muO-conotoxin MrVIB blocks TTX-resistant sodium channel NaV1.8 and has a long-lasting analgesic activity. Biochemistry (2006) 45: 3116-0 [P, NA] |
| Bulaj,G., Zhang,M.M., Green,B.R., Fiedler,B., Layer,R.T., Wei,S., Nielsen,J.S., Low,S.J., Klein,B.D., Wagstaff,J.D., Chicoine,L., Harty,T.P., Terlau,H., Yoshikami,D. and Olivera,B.M. Synthetic muO-conotoxin MrVIB blocks TTX-resistant sodium channel NaV1.8 and has a long-lasting analgesic activity Biochemistry (2006) 45: 7404-7414 [P, NA] |
| Chen,W.H., Han,Y.H., Wang,Q., Miao,X.W., Ou,L. and Shao,X.X. cDNA cloning of two novel T-superfamily conotoxins from Conus leopardus Acta Biochim. Biophys. Sin. (Shanghai) (2006) 38: 287-291 [P, NA] |
| Chen,W.H., Han,Y.H., Wang,Q., Miao,X.W., Ou,L. and Shao,X.X. cDNA cloning of two novel T-superfamily conotoxins from Conus leopardus Acta Biochim. Biophys. Sin. (Shanghai) (2006) 38: 287-291 [P, NA] |
| Chi,S.W., Kim,D.H., Olivera,B.M., McIntosh,J.M. and Han,K.H. NMR structure determination of alpha-conotoxin BuIA, a novel neuronal nicotinic acetylcholine receptor antagonist with an unusual 4/4 disulfide scaffold Biochem. Biophys. Res. Commun. (2006) 349: 1228-1234 [P, NA] |
| Chi,S.W., Kim,D.H., Olivera,B.M., McIntosh,J.M. and Han,K.H. Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist alpha-conotoxin OmIA that discriminates alpha3 vs. alpha6 nAChR subtypes Biochem. Biophys. Res. Commun. (2006) 345: 248-254 [P, NA] |
| Clark,R.J., Fischer,H., Nevin,S.T., Adams,D.J. and Craik,D.J. The synthesis, structural characterization, and receptor specificity of the alpha-conotoxin Vc1.1 J. Biol. Chem. (2006) 281: 23254-23263 [P, NA] |
| Craik,D.J., Daly,N.L. and Nielsen,K.J. Cyclized conotoxin peptides Patent: US 7001883-A 29 21-FEB-2006; The University of Queensland; Queensland; AU; (2006) [P, NA] |
| Croker D., Dutertre S., Alewood P., and Lewis R. Discovery and pharmacology of conopressin-T, a novel vasopressin-like peptide from Conus tulipa. Acta Pharmacologica Sinica (2006) 27: 351-351 [P, NA] |
| Czerwiec,E., Kalume,D.E., Roepstorff,P., Hambe,B., Furie,B., Furie,B.C. and Stenflo,J. Novel gamma-carboxyglutamic acid-containing peptides from the venom of Conus textile. FEBS J. (2006) 273: 2779-2788 [P, NA] |
| Drinkwater,R.D., Lewis,R.J., Alewood,P.F. and Nielsen,K.J. Omega.conotoxin peptides Patent: US 7101849 05-SEP-2006 (2006) [P, NA] |
| Dutertre,S., Lumsden,N.G., Alewood,P.F. and Lewis,R.J. Isolation and characterisation of conomap-Vt, a D-amino acid containing excitatory peptide from the venom of a vermivorous cone snail. FEBS Lett. (2006) 580: 3860-3866 [P, NA] |
| Dy,C.Y., Buczek,P., Imperial,J.S., Bulaj,G. and Horvath,M.P. Structure of conkunitzin-S1, a neurotoxin and Kunitz-fold disulfide variant from cone snail. Acta Crystallogr. D Biol. Crystallogr. (2006) 62: 980-990 [P, NA] |
| Ellison,M., Haberlandt,C., Gomez-Casati,M.E., Watkins,M., Elgoyhen,A.B., McIntosh,J.M. and Olivera,B.M. Alpha-RgIA: a novel conotoxin that specifically and potently blocks the alpha9alpha10 nAChR Biochemistry (2006) 45: 1511-1517 [P, NA] |
| Franco,A., Pisarewicz,K., Moller,C., Mora,D., Fields,G.B. and Mari,F. Hyperhydroxylation: a new strategy for neuronal targeting by venomous marine molluscs Prog. Mol. Subcell. Biol. (2006) 43: 83-0 [P, NA] |
| Han,Y.H., Wang,Q., Jiang,H., Liu,L., Xiao,C., Yuan,D.D., Shao,X.X., Dai,Q.Y., Cheng,J.S. and Chi,C.W. Characterization of novel M-superfamily conotoxins with new disulfide linkage FEBS J. (2006) 273: 4972-4982 [P, NA] |
| Imperial,J.S., Bansal,P.S., Alewood,P.F., Daly,N.L., Craik,D.J., Sporning,A., Terlau,H., Lopez-Vera,E., Bandyopadhyay,P.K. and Olivera,B.M. A novel conotoxin inhibitor of Kv1.6 channel and nAChR subtypes defines a new superfamily of conotoxins Biochemistry (2006) 45: 8331-8340 [P, NA] |
| Jakubowski,J.A., Kelley,W.P. and Sweedler,J.V. Screening for post-translational modifications in conotoxins using liquid chromatography/mass spectrometry: an important component of conotoxin discovery Toxicon (2006) 47: 688-699 [P, NA] |
| Jiang,H., Wang,C.Z., Xu,C.Q., Fan,C.X., Dai,X.D., Chen,J.S. and Chi,C.W. A novel M-superfamily conotoxin with a unique motif from Conus vexillum Peptides (2006) 27: 682-689 [P, NA] |
| Jiang,H., Xu,C.Q., Wang,C.Z., Fan,C.X., Zhao,T.Y., Chen,J.S. and Chi,C.W. Two novel O-superfamily conotoxins from Conus vexillum Toxicon (2006) 47: 425-436 [P, NA] |
| Kang,T.S., Jois,S.D. and Kini,R.M. Solution structures of two structural isoforms of CMrVIA chi/lambda-conotoxin Biomacromolecules (2006) 7: 2337-2346 [P, NA] |
| Kasheverov,I.E., Chiara,D.C., Zhmak,M.N., Maslennikov,I.V., Pashkov,V.S., Arseniev,A.S., Utkin,Y.N., Cohen,J.B. and Tsetlin,V.I. alpha-Conotoxin GI benzoylphenylalanine derivatives. (1)H-NMR structures and photoaffinity labeling of the Torpedo californica nicotinic acetylcholine receptor FEBS J. (2006) 273: 1373-1388 [P, NA] |
| Kelley,W.P., Schulz,J.R., Jakubowski,J.A., Gilly,W.F. and Sweedler,J.V. Two toxins from Conus striatus that individually induce tetanic paralysis. Biochemistry (2006) 45: 14212-14222 [P, NA] |
| Loughnan,M., Nicke,A., Jones,A., Schroeder,C.I., Nevin,S.T., Adams,D.J., Alewood,P.F. and Lewis,R.J. Identification of a novel class of nicotinic receptor antagonists: dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum J. Biol. Chem. (2006) 281: 24745-24755 [P, NA] |
| Lovelace,E.S., Armishaw,C.J., Colgrave,M.L., Wahlstrom,M.E., Alewood,P.F., Daly,N.L. and Craik,D.J. Cyclic MrIA: a stable and potent cyclic conotoxin with a novel topological fold that targets the norepinephrine transporter J. Med. Chem. (2006) 49: 6561-6568 [P, NA] |
| Luo,S., Zhangsun,D., Lin,Q., Xie,L., Wu,Y. and Zhu,X. Sequence diversity of O-superfamily conopetides from Conus marmoreus native to Hainan Peptides (2006) 27: 3058-3068 [P, NA] |
| Luo,S., Zhangsun,D., Wu,Y., Zhu,X., Xie,L., Hu,Y., Zhang,J. and Zhao,X. Identification and molecular diversity of T-superfamily conotoxins from Conus lividus and Conus litteratus Chem Biol Drug Des (2006) 68: 97-106 [P, NA] |
| Luo,S., Zhangsun,D., Zhang,B., Chen,X. and Feng,J. Direct cDNA cloning of novel conotoxins of the T-superfamily from Conus textile Peptides (2006) 27: 2640-2646 [P, NA] |
| Luo,S., Zhangsun,D., Zhang,B., Quan,Y. and Wu,Y. Novel alpha-conotoxins identified by gene sequencing from cone snails native to Hainan, and their sequence diversity J. Pept. Sci. (2006) 12: 693-704 [P, NA] |
| Mondal,S., Babu,R.M., Bhavna,R. and Ramakumar,S. I-conotoxin superfamily revisited J. Pept. Sci. (2006) 12: 679-685 [P, NA] |
| Nair,S.S., Nilsson,C.L., Emmett,M.R., Schaub,T.M., Gowd,K.H., Thakur,S.S., Krishnan,K.S., Balaram,P. and Marshall,A.G. De novo sequencing and disulfide mapping of a bromotryptophan-containing conotoxin by Fourier transform ion cyclotron resonance mass spectrometry Anal. Chem. (2006) 78: 8082-8088 [P, NA] |
| Olivera,B.M. Conus peptides: biodiversity-based discovery and exogenomics. J. Biol. Chem. (2006) 281: 31173-31177 [P, NA] |
| Peng,C., Tang,S., Pi,C., Liu,J., Wang,F., Wang,L., Zhou,W. and Xu,A. Discovery of a novel class of conotoxin from Conus litteratus, lt14a, with a unique cysteine pattern Peptides (2006) 27: 2174-2181 [P, NA] |
| Pi,C., Liu,J., Peng,C., Liu,Y., Jiang,X., Zhao,Y., Tang,S., Wang,L., Dong,M., Chen,S. and Xu,A. Diversity and evolution of conotoxins based on gene expression profiling of Conus litteratus Genomics (2006) 88: 809-819 [P, NA] |
| Pi,C., Liu,Y., Peng,C., Jiang,X., Liu,J., Xu,B., Yu,X., Yu,Y., Jiang,X., Wang,L., Dong,M., Chen,S. and Xu,A.L. Analysis of expressed sequence tags from the venom ducts of Conus striatus: focusing on the expression profile of conotoxins Biochimie (2006) 88: 131-140 [P, NA] |
| Quinton,L., Le Caer,J.P., Vinh,J., Gilles,N. and Chamot-Rooke,J. Fourier transform mass spectrometry: a powerful tool for toxin analysis Toxicon (2006) 47: 715-726 [P, NA] |
| Sabareesh,V., Gowd,K.H., Ramasamy,P., Sudarslal,S., Krishnan,K.S., Sikdar,S.K. and Balaram,P. Characterization of contryphans from Conus loroisii and Conus amadis that target calcium channels Peptides (2006) 27: 2647-2654 [P, NA] |
| Shiembob,D.L., Roberts,R.L., Luetje,C.W. and McIntosh,J.M. Determinants of alpha-conotoxin BuIA selectivity on the nicotinic acetylcholine receptor beta subunit. Biochemistry (2006) 45: 11200-11207 [P, NA] |
| Talley,T.T., Olivera,B.M., Han,K.H., Christensen,S.B., Dowell,C., Tsigelny,I., Ho,K.Y., Taylor,P. and McIntosh,J.M. Alpha-conotoxin OmIA is a potent ligand for the acetylcholine-binding protein as well as alpha3beta2 and alpha7 nicotinic acetylcholine receptors J. Biol. Chem. (2006) 281: 24678-24686 [P, NA] |
| Teichert,R.W., Lopez-Vera,E., Gulyas,J., Watkins,M., Rivier,J. and Olivera,B.M. Definition and characterization of the short alphaA-conotoxins: a single residue determines dissociation kinetics from the fetal muscle nicotinic acetylcholine receptor Biochemistry (2006) 45: 1304-1312 [P, NA] |
| Ulens,C., Hogg,R.C., Celie,P.H., Bertrand,D., Tsetlin,V., Smit,A.B. and Sixma,T.K. Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP Proc. Natl. Acad. Sci. U.S.A. (2006) 103: 3615-3620 [P, NA] |
| Vincler,M., Wittenauer,S., Parker,R., Ellison,M., Olivera,B.M. and McIntosh,J.M. Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors. Proc. Natl. Acad. Sci. U.S.A. (2006) 103: 17880-17884 [P, NA] |
| Wang,C.Z., Zhang,H., Jiang,H., Lu,W., Zhao,Z.Q. and Chi,C.W. A novel conotoxin from Conus striatus, mu-SIIIA, selectively blocking rat tetrodotoxin-resistant sodium channels Toxicon (2006) 47: 122-132 [P, NA] |
| Watkins,M. and Olivera,B.M. Genes expressed in a turrid venom duct: divergence and similarity to conotoxins. J. Mol. Evol. (2006) 62: 247-256 [P, NA] |
| Zhang,M.M., Fiedler,B., Green,B.R., Catlin,P., Watkins,M., Garrett,J.E., Smith,B.J., Yoshikami,D., Olivera,B.M. and Bulaj,G. Structural and functional diversities among mu-conotoxins targeting TTX-resistant sodium channels Biochemistry (2006) 45: 3723-3732 [P, NA] |
| Zhangsun, D., Luo, S., Wu, Y., Zhu, X., Hu, Y. and Xie, L. Novel O-superfamily conotoxins identified by cDNA cloning from three vermivorous Conus species. Chem Biol Drug Des. (2006) 68: 256-265 [P, NA] |
| Zorn,S., Leipold,E., Hansel,A., Bulaj,G., Olivera,B.M., Terlau,H. and Heinemann,S.H. The muO-conotoxin MrVIA inhibits voltage-gated sodium channels by associating with domain-3 FEBS Lett. (2006) 580: 1360-1364 [P, NA] |
| Zugasti-Cruz,A., Maillo,M., Lopez-Vera,E., Falcon,A., Heimer de la Cotera,E.P., Olivera,B.M. and Aguilar,M.B. Amino acid sequence and biological activity of a gamma-conotoxin-like peptide from the worm-hunting snail Conus austini Peptides (2006) 27: 506-511 [P, NA] |
2005 Aguilar,M.B., López-Vera,E., Imperial,J.S., Falcón,A., Olivera,B.M. and de la Cotera,E.P. Putative gamma-conotoxins in vermivorous cone snails: the case of Conus delessertii Peptides (2005) 26: 23-27 [P, NA] |
| Aguilar,M.B., López-Vera,E., Ortiz,E., Becerril,B., Possani,L.D., Olivera,B.M. and Heimer de la Cotera,E.P. A novel conotoxin from Conus delessertii with posttranslationally modified lysine residues Biochemistry (2005) 44: 11130-11136 [P, NA] |
| Azam,L., Dowell,C., Watkins,M., Stitzel,J.A., Olivera,B.M. and McIntosh,J.M. Alpha-conotoxin BuIA, a novel peptide from Conus bullatus, distinguishes among neuronal nicotinic acetylcholine receptors J. Biol. Chem. (2005) 280: 80-87 [P, NA] |
| Bayrhuber,M., Vijayan,V., Ferber,M., Graf,R., Korukottu,J., Imperial,J., Garrett,J.E., Olivera,B.M., Terlau,H., Zweckstetter,M. and Becker,S. Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family. Structural and functional characterization. J. Biol. Chem. (2005) 280: 23766-23770 [P, NA] |
| Bingham,J.P., Broxton,N.M., Livett,B.G., Down,J.G., Jones,A. and Moczydlowski,E.G. Optimizing the connectivity in disulfide-rich peptides: alpha-conotoxin SII as a case study Anal. Biochem. (2005) 338: 48-61 [P, NA] |
| Brown,M.A., Begley,G.S., Czerwiec,E., Stenberg,L.M., Jacobs,M., Kalume,D.E., Roepstorff,P., Stenflo,J., Furie,B.C. and Furie,B. Precursors of novel Gla-containing conotoxins contain a carboxy-terminal recognition site that directs gamma-carboxylation Biochemistry (2005) 44: 9150-9159 [P, NA] |
| Buczek,O., Yoshikami,D., Bulaj,G., Jimenez,E.C. and Olivera,B.M. Post-translational amino acid isomerization: a functionally important D-amino acid in an excitatory peptide J. Biol. Chem. (2005) 280: 4247-4253 [P, NA] |
| Buczek,O., Yoshikami,D., Watkins,M., Bulaj,G., Jimenez,E.C. and Olivera,B.M. Characterization of D-amino-acid-containing excitatory conotoxins and redefinition of the I-conotoxin superfamily FEBS J. (2005) 272: 4178-4188 [P, NA] |
| Bulaj,G., West,P.J., Garrett,J.E., Watkins,M., Zhang,M.M., Norton,R.S., Smith,B.J., Yoshikami,D. and Olivera,B.M. Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels Biochemistry (2005) 44: 7259-7265 [P, NA] |
| Celie,P.H., Kasheverov,I.E., Mordvintsev,D.Y., Hogg,R.C., van Nierop,P., van Elk,R., van Rossum-Fikkert,S.E., Zhmak,M.N., Bertrand,D., Tsetlin,V., Sixma,T.K. and Smit,A.B. Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant Nat. Struct. Mol. Biol. (2005) 12: 582-588 [P, NA] |
| Chi,S.W., Lee,S.H., Kim,D.H., Kim,J.S., Olivera,B.M., McIntosh,J.M. and Han,K.H. Solution structure of alpha-conotoxin PIA, a novel antagonist of alpha6 subunit containing nicotinic acetylcholine receptors Biochem. Biophys. Res. Commun. (2005) 338: 1990-1997 [P, NA] |
| Clark,R.J., Fischer,H., Dempster,L., Daly,N.L., Rosengren,K.J., Nevin,S.T., Meunier,F.A., Adams,D.J. and Craik,D.J. Engineering stable peptide toxins by means of backbone cyclization: stabilization of the alpha-conotoxin MII Proc. Natl. Acad. Sci. U.S.A. (2005) 102: 13767-13772 [P, NA] |
| Corpuz,G.P., Jacobsen,R.B., Jimenez,E.C., Watkins,M., Walker,C., Colledge,C., Garrett,J.E., McDougal,O., Li,W., Gray,W.R., Hillyard,D.R., Rivier,J., McIntosh,J.M., Cruz,L.J. and Olivera,B.M. Definition of the M-conotoxin superfamily: characterization of novel peptides from molluscivorous Conus venoms Biochemistry (2005) 44: 8176-8186 [P, NA] |
| Dutertre,S., Nicke,A., and Lewis,R.J. Beta2 subunit contribution to 4/7 alpha-conotoxin binding to the nicotinic acetylcholine receptor. J. Biol. Chem. (2005) 280: 30460-30468 [P, NA] |
| Gowd,K.H., Sabareesh,V., Sudarslal,S., Iengar,P., Franklin,B., Fernando,A., Dewan,K., Ramaswami,M., Sarma,S.P., Sikdar,S., Balaram,P. and Krishnan,K.S. Novel peptides of therapeutic promise from Indian Conidae Ann. N. Y. Acad. Sci. (2005) 1056: 462-0 [P, NA] |
| Han,Y.H., Wang,Q., Jiang,H., Miao,X.W., Chen,J.S. and Chi,C.W. Sequence diversity of T-superfamily conotoxins from Conus marmoreus Toxicon (2005) 45: 481-487 [P, NA] |
| Hansen,S.B., Sulzenbacher,G., Huxford,T., Marchot,P., Taylor,P. and Bourne,Y. Structures Of Aplysia Achbp Complexes With Nicotinic Agonists And Antagonists Reveal Distinctive Binding Interfaces And Conformations Embo J. (2005) 24: 3635-0 [P, NA] |
| Huang,X., Dong,F. and Zhou,H.X. Electrostatic recognition and induced fit in the kappa-PVIIA toxin binding to Shaker potassium channel. J. Am. Chem. Soc. (2005) 127: 6836-6849 [P, NA] |
| Kauferstein,S., Melaun,C. and Mebs,D. Direct cDNA cloning of novel conopeptide precursors of the O-superfamily Peptides (2005) 26: 361-367 [P, NA] |
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| Leipold,E., Hansel,A., Olivera,B.M., Terlau,H. and Heinemann,S.H. Molecular interaction of delta-conotoxins with voltage-gated sodium channels FEBS Lett. (2005) 579: 3881-3884 [P, NA] |
| Lima,V., Mueller,A., Kamikihara,S.Y., Raymundi,V., Alewood,D., Lewis,R.J., Chen,Z., Minneman,K.P. and Pupo,A.S. Differential antagonism by conotoxin rho-TIA of contractions mediated by distinct alpha1-adrenoceptor subtypes in rat vas deferens, spleen and aorta Eur. J. Pharmacol. (2005) 508: 183-192 [P, NA] |
| McIntosh,J.M., Plazas,P.V., Watkins,M., Gomez-Casati,M.E., Olivera,B.M. and Elgoyhen,A.B. A novel alpha-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between rat alpha9alpha10 and alpha7 nicotinic cholinergic receptors J. Biol. Chem. (2005) 280: 30107-30112 [P, NA] |
| Moller,C., Rahmankhah,S., Lauer-Fields,J., Bubis,J., Fields,G.B. and Mari,F. A novel conotoxin framework with a helix-loop-helix (Cs alpha/alpha) fold Biochemistry (2005) 44: 15986-15996 [P, NA] |
| Mondal,S., Vijayan,R., Shichina,K., Babu,R.M. and Ramakumar,S. I-superfamily conotoxins: sequence and structure analysis In Silico Biol. (Gedrukt) (2005) 5: 557-571 [P, NA] |
| Nielsen,C.K., Lewis,R.J., Alewood,D., Drinkwater,R., Palant,E., Patterson,M., Yaksh,T.L., McCumber,D. and Smith,M.T. Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain Pain (2005) 118: 112-124 [P, NA] |
| Nilsson,K.P., Lovelace,E.S., Caesar,C.E., Tynngard,N., Alewood,P.F., Johansson,H.M., Sharpe,I.A., Lewis,R.J., Daly,N.L. and Craik,D.J. Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporter Biopolymers (2005) 80: 815-823 [P, NA] |
| Olivera,B.M., Layer,R.T., McIntosh,J.M., Nielsen,J.S. and Jones,R.M. Alpha.-conotoxin peptides Patent: US 6855805 15-FEB-2005 (2005) [P, NA] |
| Olivera,B.M., McIntosh,J.M., Yoshikami,D., Cartier,G.E. and Luo,S. Uses of .alpha.-conotoxin peptides Patent: US 6958323 25-OCT-2005 (2005) [P, NA] |
| Pisarewicz,K., Mora,D., Pflueger,F.C., Fields,G.B. and Mari,F. Polypeptide chains containing D-gamma-hydroxyvaline J. Am. Chem. Soc. (2005) 127: 6207-6215 [P, NA] |
| Sarma,S.P., Kumar,G.S., Sudarslal,S., Iengar,P., Ramasamy,P., Sikdar,S.K., Krishnan,K.S. and Balaram,P. Solution structure of delta-Am2766: a highly hydrophobic delta-conotoxin from Conus amadis that inhibits inactivation of neuronal voltage-gated sodium channels. Chem. Biodivers. (2005) 2: 535-556 [P, NA] |
| Satkunanathan,N., Livett,B., Gayler,K., Sandall,D., Down,J. and Khalil,Z. Alpha-conotoxin Vc1.1 alleviates neuropathic pain and accelerates functional recovery of injured neurones Brain Res. (2005) 1059: 149-158 [P, NA] |
| Teichert,R.W., Jimenez,E.C. and Olivera,B.M. Alpha S-conotoxin RVIIIA: a structurally unique conotoxin that broadly targets nicotinic acetylcholine receptors Biochemistry (2005) 44: 7897-7902 [P, NA] |
| Teichert,R.W., Rivier,J., Torres,J., Dykert,J., Miller,C. and Olivera,B.M. A uniquely selective inhibitor of the mammalian fetal neuromuscular nicotinic acetylcholine receptor J. Neurosci. (2005) 25: 732-736 [P, NA] |
| Vianna Braga,M.C., Konno,K., Portaro,F.C., de Freitas,J.C., Yamane,T., Olivera,B.M. and Pimenta,D.C. Mass spectrometric and high performance liquid chromatography profiling of the venom of the Brazilian vermivorous mollusk Conus regius: feeding behavior and identification of one novel conotoxin Toxicon (2005) 45: 113-122 [P, NA] |
| Wen,L., Yang,S., Qiao,H., Liu,Z., Zhou,W., Zhang,Y. and Huang,P. SO-3, a new O-superfamily conopeptide derived from Conus striatus, selectively inhibits N-type calcium currents in cultured hippocampal neurons Br. J. Pharmacol. (2005) 145: 728-739 [P, NA] |
| West,P.J. and Yoshikami,D. Effects of delta-conotoxins PVIA and SVIE on sodium channels in the amphibian sympathetic nervous system. J Neurophysiol (2005) 94: 3916-3924 [P, NA] |
| Zhao,T.-Y., Cao,Y., Dai,X.-D., Fan,C.-X. and Chen,J.-S. Purification, sequence and disulfide bonding pattern of a novel conotoxin BtIIIB Acta Chim. Sin. (2005) 63: 163-0 [P, NA] |
2004 Al-Sabi,A., Lennartz,D., Ferber,M., Gulyas,J., Rivier,J.E., Olivera,B.M., Carlomagno,T. and Terlau,H. KappaM-conotoxin RIIIK, structural and functional novelty in a K+ channel antagonist. Biochemistry (2004) 43: 8625-8635 [P, NA] |
| Barbier,J., Lamthanh,H., Le Gall,F., Favreau,P., Benoit,E., Chen,H., Gilles,N., Ilan,N., Heinemann,S.H., Gordon,D., Menez,A. and Molgo,J. A delta-conotoxin from Conus ermineus venom inhibits inactivation in vertebrate neuronal Na+ channels but not in skeletal and cardiac muscles J. Biol. Chem. (2004) 279: 4680-4685 [P, NA] |
| Chen,Z., Rogge,G., Hague,C., Alewood,D., Colless,B., Lewis,R.J. and Minneman,K.P. Subtype-selective noncompetitive or competitive inhibition of human alpha1-adrenergic receptors by rho-TIA J. Biol. Chem. (2004) 279: 35326-35333 [P, NA] |
| Chi,S.W., Kim,D.H., Olivera,B.M., McIntosh,J.M. and Han,K.H. Solution conformation of alpha-conotoxin GIC, a novel potent antagonist of alpha3beta2 nicotinic acetylcholine receptors Biochem. J. (2004) 380: 347-352 [P, NA] |
| Chierici,S., Jourdan,M., Figuet,M. and Dumy,P. A case study of 2,2-dimethylthiazolidine as locked cis proline amide bond: synthesis, NMR and molecular modeling studies of a [small delta]-conotoxin EVIA peptide analog Org. Biomol. Chem. (2004) 2: 2437-2441 [P, NA] |
| Craig,A.G., Griffen,D., Olivera,B.M., Watkins,M., Hillyard,D.R., Imperial,J., Cruz,L.J., Wagstaff,J.D., Layer,R.T., Jones,R.M. and McCabe,R.T. Contulakin-G, analogs thereof and uses therefor Patent: US 6696408 24-FEB-2004 (2004) [P, NA] |
| Daly,N.L., Ekberg,J.A., Thomas,L., Adams,D.J., Lewis,R.J. and Craik,D.J. Structures of muO-conotoxins from Conus marmoreus. I nhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons J. Biol. Chem. (2004) 279: 25774-25782 [P, NA] |
| Duda,T.F. Jr. and Palumbi,S.R. Gene expression and feeding ecology: evolution of piscivory in the venomous gastropod genus Conus. Proc. Biol. Sci. (2004) 271: 1165-1174 [P, NA] |
| Eliseo,T., Cicero,D.O., Romeo,C., Schinina,M.E., Massilia,G.R., Polticelli,F., Ascenzi,P. and Paci,M. Solution structure of the cyclic peptide contryphan-Vn, a Ca2+-dependent K+ channel modulator Biopolymers (2004) 74: 189-198 [P, NA] |
| Ellison,M., Gao,F., Wang,H.L., Sine,S.M. and Olivera,B.M. Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes. Biochemistry (2004) 43: 16019-16026 [P, NA] |
| Everhart,D., Cartier,G.E., Malhotra,A., Gomes,A.V., McIntosh,J.M. and Luetje,C.W. Determinants of potency on alpha-conotoxin MII, a peptide antagonist of neuronal nicotinic receptors Biochemistry (2004) 43: 2732-2737 [P, NA] |
| Grant,M.A., Hansson,K., Furie,B.C., Furie,B., Stenflo,J. and Rigby,A.C. The metal-free and calcium-bound structures of a gamma-carboxyglutamic acid-containing contryphan from Conus marmoreus, glacontryphan-M J. Biol. Chem. (2004) 279: 32464-32473 [P, NA] |
| Hansson,K., Furie,B., Furie,B.C. and Stenflo,J. Isolation and characterization of three novel Gla-containing Conus marmoreus venom peptides, one with a novel cysteine pattern Biochem. Biophys. Res. Commun. (2004) 319: 1081-1087 [P, NA] |
| Hansson,K., Ma,X., Eliasson,L., Czerwiec,E., Furie,B., Furie,B.C., Rorsman,P. and Stenflo,J. The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus. J. Biol. Chem. (2004) 279: 32453-32463 [P, NA] |
| Hansson,K., Ma,X., Eliasson,L., Czerwiec,E., Furie,B., Furie,B.C., Rorsman,P. and Stenflo,J. The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus. J. Biol. Chem. (2004) 279: 32453-32463 [P, NA] |
| Jakubowski,J.A. and Sweedler, J.V. Sequencing and mass profiling highly modified conotoxins using global reduction/alkylation followed by mass spectrometry Anal. Chem. (2004) 76: 6541-6547 [P, NA] |
| Jakubowski,J.A., Keays,D.A., Kelley,W.P., Sandall,D.W., Bingham,J.P., Livett,B.G., Gayler,K.R. and Sweedler,J.V. Determining sequences and post-translational modifications of novel conotoxins in Conus victoriae using cDNA sequencing and mass spectrometry J Mass Spectrom (2004) 39: 548-557 [P, NA] |
| Jimenez,E.C., Watkins,M. and Olivera,B.M. Multiple 6-bromotryptophan residues in a sleep-inducing peptide Biochemistry (2004) 43: 12343-12348 [P, NA] |
| Kauferstein,S., Huys,I., Kuch,U., Melaun,C., Tytgat,J. and Mebs,D. Novel conopeptides of the I-superfamily occur in several clades of cone snails Toxicon (2004) 44: 539-548 [P, NA] |
| Loughnan,M.L., Nicke,A., Jones,A., Adams,D.J., Alewood,P.F. and Lewis,R.J. Chemical and functional identification and characterization of novel sulfated alpha-conotoxins from the cone snail Conus anemone J. Med. Chem. (2004) 47: 1234-1241 [P, NA] |
| McDougal,O.M. and Dale Poulter,C. Three-dimensional structure of the mini-M conotoxin mr3a Biochemistry (2004) 43: 425-429 [P, NA] |
| McIntosh,J.M., Azam,L., Staheli,S., Dowell,C., Lindstrom,J.M., Kuryatov,A., Garrett,J.E., Marks,M.J. and Whiteaker,P. Analogs of alpha-conotoxin MII are selective for alpha6-containing nicotinic acetylcholine receptors. Mol. Pharmacol. (2004) 65: 944-952 [P, NA] |
| McIntosh,J.M., Olivera,B.M., Cruz,L.J., Corpuz,G.P., Jones,R.M. and Garrett,J.E. Conotoxin peptides Patent: US 6767896 27-JUL-2004 (2004) [P, NA] |
| Miljanich,G.P. Ziconotide: neuronal calcium channel blocker for treating severe chronic pain Curr. Med. Chem. (2004) 11: 3029-3040 [P, NA] |
| Mould,J., Yasuda,T., Schroeder,C.I., Beedle,A.M., Doering,C.J., Zamponi,G.W., Adams,D.J. and Lewis,R.J. The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels. J. Biol. Chem. (2004) 279: 34705-34714 [P, NA] |
| Olivera,B.M., Cartier,G.E., Watkins,M., Hillyard,D.R., McIntosh,J.M., Layer,R.T. and Jones,R.M. O-superfamily conotoxin peptides Patent: US 6762165-A 282 13-JUL-2004; University of Utah Research Foundation and Cognetix, Inc.; Salt Lake City, UT (2004) [P, NA] |
| Olivera,B.M., McIntosh,J.M., Garrett,J.E., Cruz,L.J., Jones,R.M., Cartier,G.E. and Wagstaff,J.D. Mu-conopeptides Patent: US 6727226-A 80 27-APR-2004; University of Utah Research Foundation and Cognetix, Inc.; Salt Lake City, UT (2004) [P, NA] |
| Santos,A.D., McIntosh,J.M., Hillyard,D.R., Cruz,L.J. and Olivera,B.M. The A-superfamily of conotoxins: structural and functional divergence J. Biol. Chem. (2004) 279: 17596-17606 [P, NA] |
| Teichert,R.W., Rivier,J., Dykert,J., Cervini,L., Gulyas,J., Bulaj,G., Ellison,M. and Olivera,B.M. AlphaA-Conotoxin OIVA defines a new alphaA-conotoxin subfamily of nicotinic acetylcholine receptor inhibitors Toxicon (2004) 44: 207-214 [P, NA] |
| Volpon,L., Lamthanh,H., Barbier,J., Gilles,N., Molgo,J., Menez,A. and Lancelin,J.M. NMR solution structures of delta-conotoxin EVIA from Conus ermineus that selectively acts on vertebrate neuronal Na+ channels J. Biol. Chem. (2004) 279: 21356-21366 [P, NA] |
| Walker,C.S., Shetty,R., Jimenez,E.C., McIntosh,J.M., Olivera,B.M., Watkins,M., Jones,R.M. and Shen,G.S. I-superfamily conotoxins Patent: US 6767895-A 440 27-JUL-2004; Cognetix, Inc. and University of Utah Research Foundation; Salt Lake City, UT (2004) [P, NA] |
| Wang,C.Z., Ou,Z.L. and Chi,C.W. Gene cloning and functional studies of alpha conotoxin SII (Unpublished) [P, NA] |
| Watkins,M., Olivera,B.M., Hillyard,D.R., McIntosh,M.J. and Jones,R.M. Patent: 6797808 -US 28-SEP-2004 Patent: 6797808 (2004) [P, NA] |
2003 Adams,D.J., Smith,A.B., Schroeder,C.I., Yasuda,T. and Lewis,R.J. Omega-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals J. Biol. Chem. (2003) 278: 4057-4062 [P, NA] |
| Blanchfield JT, Dutton JL, Hogg RC, Gallagher OP, Craik DJ, Jones A, Adams DJ, Lewis RJ, Alewood PF, Toth I Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of alpha-conotoxin MII. J Med Chem (2003) 46: 1266-1272 [P, NA] |
| Bryan-Lluka,L.J., Bonisch,H. and Lewis,R.J. chi-Conopeptide MrIA partially overlaps desipramine and cocaine binding sites on the human norepinephrine transporter J. Biol. Chem. (2003) 278: 40324-40329 [P, NA] |
| Chi,S.W., Park,K.H., Suk,J.E., Olivera,B.M., McIntosh,J.M. and Han,K.H. Solution conformation of alphaA-conotoxin EIVA, a potent neuromuscular nicotinic acetylcholine receptor antagonist from Conus ermineus J. Biol. Chem. (2003) 278: 42208-42213 [P, NA] |
| Dai,Q., Liu,F., Zhou,Y., Lu,B., Yu,F. and Huang,P. The synthesis of SO-3, a conopeptide with high analgesic activity derived from Conus striatus J. Nat. Prod. (2003) 66: 1276-1279 [P, NA] |
| Dowell,C., Olivera,B.M., Garrett,J.E., Staheli,S.T., Watkins,M., Kuryatov,A., Yoshikami,D., Lindstrom,J.M. and McIntosh,J.M. Alpha-conotoxin PIA is selective for alpha6 subunit-containing nicotinic acetylcholine receptors J. Neurosci. (2003) 23: 8445-8452 [P, NA] |
| Ellison,M.A., McIntosh,J.M. and Olivera,B.M. alpha-Conotoxins ImI and ImII: similar alpha 7 nicotinic receptor antagonists act at different sites J. Biol. Chem. (2003) 278: 757-764 [P, NA] |
| Fainzilber,M., Kits,K.S., Burlingame,A.L., Olivera,B.M., Walker,C., Watkins,M., Shetty,R., Cruz,L.J., Imperial,J. and Colledge,C. Gamma-conopeptides Patent: US 6624288-A 25 23-SEP-2003; Cognetix, Inc. and University of Utah Research Foundation; Salt Lake City, UT (2003) [P, NA] |
| Fan,C.X., Chen,X.K., Zhang,C., Wang,L.X., Duan,K.L., He,L.L., Cao,Y., Liu,S.Y., Zhong,M.N., Ulens,C., Tytgat,J., Chen,J.S., Chi,C.W. and Zhou,Z. A Novel Conotoxin from Conus betulinus, kappa -BtX, Unique in Cysteine Pattern and in Function as a Specific BK Channel Modulator J. Biol. Chem. (2003) 278: 12624-12633 [P, NA] |
| Ferber,M., Sporning,A., Jeserich,G., DeLaCruz,R., Watkins,M., Olivera,B.M. and Terlau,H. A novel conus peptide ligand for K+ channels J. Biol. Chem. (2003) 278: 2177-2183 [P, NA] |
| Hillyard, D.R., Mcintosh, M.J., Jones, R.M., Cartier, E.G., Watkins, M., Olivera, B.M. and Layer, R.T. O-Superfamily Conotoxin Peptides Patent: JP 2003533178-A 1 11-NOV-2003; (2003) [P, NA] |
| Hogg,R.C., Hopping,G., Alewood,P.F., Adams,D.J. and Bertrand,D. Alpha-conotoxins PnIA and [A10L]PnIA stabilize different states of the alpha7-L247T nicotinic acetylcholine receptor. J. Biol. Chem. (2003) 278: 26908-26914 [P, NA] |
| Jimenez,E.C., Shetty,R.P., Lirazan,M., Rivier,J., Walker,C., Abogadie,F.C., Yoshikami,D., Cruz,L.J. and Olivera,B.M. Novel excitatory Conus peptides define a new conotoxin superfamily J. Neurochem. (2003) 85: 610-621 [P, NA] |
| Kauferstein,S., Huys,I., Lamthanh,H., Stocklin,R., Sotto,F., Menez,A., Tytgat,J. and Mebs,D. A novel conotoxin inhibiting vertebrate voltage-sensitive potassium channels Toxicon (2003) 42: 43-52 [P, NA] |
| Keizer,D.W., West,P.J., Lee,E.F., Yoshikami,D., Olivera,B.M., Bulaj,G. and Norton,R.S. Structural basis for tetrodotoxin-resistant sodium channel binding by mu-conotoxin SmIIIA J. Biol. Chem. (2003) 278: 46805-46813 [P, NA] |
| Kim, J.I., Song, W.K. and Park, Y. Double mutant omega conotoxin GVIA epitope and its monoclonalantibody Patent: KR 1020030017307-A 2 20-MAR-2003; (2003) [P, NA] |
| Makino,K., Oshima,K., Kurokawa,K., Yokoyama,K., Uda,T., Tagomori,K., Iijima,Y., Najima,M., Nakano,M., Yamashita,A., Kubota,Y., Kimura,S., Yasunaga,T., Honda,T., Shinagawa,H., Hattori,M. and Iida,T. Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V cholerae Lancet (2003) 361: 743-749 [P, NA] |
| Malmberg,A.B., Gilbert,H., McCabe,R.T. and Basbaum,A.I. Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T Pain (2003) 101: 109-116 [P, NA] |
| Massilia,G.R., Eliseo,T., Grolleau,F., Lapied,B., Barbier,J., Bournaud,R., Molgo,J., Cicero,D.O., Paci,M., Schinina,M.E., Ascenzi,P. and Polticelli,F. Contryphan-Vn: a modulator of Ca2+-dependent K+ channels Biochem. Biophys. Res. Commun. (2003) 303: 238-246 [P, NA] |
| Nicke,A., Loughnan,M.L., Millard,E.L., Alewood,P.F., Adams,D.J., Daly,N.L., Craik,D.J. and Lewis,R.J. Isolation, Structure, and Activity of GID, a Novel alpha 4/7-Conotoxin with an Extended N-terminal Sequence J. Biol. Chem. (2003) 278: 3137-3144 [P, NA] |
| Nicke,A., Samochocki,M., Loughnan,M.L., Bansal,P.S., Maelicke,A. and Lewis,R.J. Alpha-conotoxins EpI and AuIB switch subtype selectivity and activity in native versus recombinant nicotinic acetylcholine receptors. FEBS Lett. (2003) 554: 219-223 [P, NA] |
| Olivera,B.M., Layer,R.T., Watkins,M., Hillyard,D.R., Mcintosh,M.J., Jones,R.M. and Schoenfeld,R. Alpha Conotoxin Peptides JP 2003525582-A 3 02-SEP-2003 (2003) [P, NA] |
| Sandall,D.W., Satkunanathan,N., Keays,D.A., Polidano,M.A., Liping,X., Pham,V., Down,J.G., Khalil,Z., Livett,B.G. and Gayler,K.R. A novel alpha-conotoxin identified by gene sequencing is active in suppressing the vascular response to selective stimulation of sensory nerves in vivo Biochemistry (2003) 42: 6904-6911 [P, NA] |
| Sharpe,I.A., Palant,E., Schroeder,C.I., Kaye,D.M., Adams,D.J., Alewood,P.F. and Lewis,R.J. Inhibition of the norepinephrine transporter by the venom peptide chi-MrIA. Site of action, Na+ dependence, and structure-activity relationship J. Biol. Chem. (2003) 278: 40317-40323 [P, NA] |
| Sharpe,I.A., Thomas,L., Loughnan,M., Motin,L., Palant,E., Croker,D.E., Alewood,D., Chen,S., Graham,R.M., Alewood,P.F., Adams,D.J. and Lewis,R.J. Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA J. Biol. Chem. (2003) 278: 34451-34457 [P, NA] |
| Sudarslal,S., Majumdar,S., Ramasamy,P., Dhawan,R., Pal,P.P., Ramaswami,M., Lala,A.K., Sikdar,S.K., Sarma,S.P., Krishnan,K.S. and Balaram,P. Sodium channel modulating activity in a delta-conotoxin from an Indian marine snail FEBS Lett. (2003) 553: 209-212 [P, NA] |
| Van Wagoner,R.M. and Ireland,C.M. An improved solution structure for psi-conotoxin PiiiE. Biochemistry (2003) 42: 6347-6352 [P, NA] |
| Van Wagoner,R.M., Jacobsen,R.B., Olivera,B.M. and Ireland,C.M. Characterization and three-dimensional structure determination of psi-conotoxin Piiif, a novel noncompetitive antagonist of nicotinic acetylcholine receptors Biochemistry (2003) 42: 6353-6362 [P, NA] |
| Walker,C., Shetty,R., Olivera,B.M., Hooper,D., Jacobsen,R., Steele,D. and Jones,R. Tau-conotoxin peptides Patent: US 6630573 07-OCT-2003 (2003) [P, NA] |
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| Wang,C.Z., Jiang,H., Ou,Z.L., Chen,J.S. and Chi,C.W. cDNA cloning of two A-superfamily conotoxins from Conus striatus Toxicon (2003) 42: 613-619 [P, NA] |
| Williams,A.J., Ling,G., Berti,R., Moffett,J.R., Yao,C., Lu,X.M. and Tortella,F.C. Treatment with the snail peptide CGX-1007 reduces DNA damage and alters gene expression of c-fos and bcl-2 following focal ischemic brain injury in rats. Exp Brain Res (2003) 153: 16-26 [P, NA] |
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2000 Atkinson,R.A., Kieffer,B., Dejaegere,A., Sirockin,F. and Lefevre,J.F. Structural and dynamic characterization of omega-conotoxin MVIIA: the binding loop exhibits slow conformational exchange Biochemistry (2000) 39: 3908-3919 [P, NA] |
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| Sevilla,P., Bruix,M., Santoro,J., Gago,F., Garcia,A.G. and Rico,M. Three-dimensional structure of omega-conotoxin GVIA determined by 1H NMR Biochem. Biophys. Res. Commun. (1993) 192: 1238-1244 [P, NA] |
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1992 Colledge,C.J., Hunsperger,J.P., Imperial,J.S. and Hillyard,D.R. Precursor structure of omega-conotoxin GVIA determined from a cDNA clone Toxicon (1992) 30: 1111-1116 [P, NA] |
| Cruz,L.J., Ramilo,C.A., Corpuz,G.P. and Olivera,B.M. Conus peptides: phylogenetic range of biological activity Biol. Bull. (1992) 183: 159-0 [P, NA] |
| Hillyard,D.R., Monje,V.D., Mintz,I.M., Bean,B.P., Nadasdi,L., Ramachandran,J., Miljanich,G., Azimi-Zoonooz,A., McIntosh,J.M., Cruz,L.J. et al. A new Conus peptide ligand for mammalian presynaptic Ca2+ channels Neuron (1992) 9: 69-77 [P, NA] |
| Olivera,B.M., Johnson,D.S., Azimi-Zonooz,A. and Cruz,L.J. Peptides in the venom of the geography cone, Conus geographus (in) Waters,D., Lavin,M., Maguire,D. and Pearn,J. (Eds.); TOXINS AND TARGETS; Harwood Academic (1992) : 19-28 [P, NA] |
| Ramilo,C., Zafaralla,G.C., Nadasdi,L., Hammerland,L.G., Yoshikami,D., Gray,W.R., Kristipati,R., Ramachandran,J., Miljanich,G.P., Olivera,B.M. and Cruz,L.J. Novel alpha- and omega-conotoxins from Conus striatus venom Biochemistry (1992) 31: 9919-9926 [P, NA] |
| van Kesteren,R.E., Smit,A.B., Dirks,R.W., de With,N.D., Geraerts,W.P. and Joosse,J. Evolution of the vasopressin/oxytocin superfamily: characterization of a cDNA encoding a vasopressin-related precursor, preproconopressin, from the mollusc Lymnaea stagnalis Proc. Natl. Acad. Sci. U.S.A. (1992) 89: 4593-4597 [P, NA] |
| Wakamatsu,K., Kohda,D., Hatanaka,H., Lancelin,J.M., Ishida,Y., Oya,M., Nakamura,H., Inagaki,F. and Sato,K. Structure-activity relationships of mu-conotoxin GIIIA: structure determination of active and inactive sodium channel blocker peptides by NMR and simulated annealing calculations Biochemistry (1992) 31: 12577-12584 [P, NA] |
1991 Fainzilber,M., Gordon,D., Hasson,A., Spira,M.E. and Zlotkin,E. Mollusc-specific toxins from the venom of Conus textile neovicarius Eur. J. Biochem. (1991) 202: 589-595 [P, NA] |
| Horne,W.A., Hawrot,E. and Tsien,R.W. omega-Conotoxin GVIA receptors of Discopyge electric organ. Characterization of omega-conotoxin binding to the nicotinic acetylcholine receptor. J. Biol. Chem. (1991) 266: 13719-13725 [P, NA] |
| Lancelin,J.M., Kohda,D., Tate,S., Yanagawa,Y., Abe,T., Satake,M. and Inagaki,F. Tertiary structure of conotoxin GIIIA in aqueous solution Biochemistry (1991) 30: 6908-6916 [P, NA] |
| Miljanich,G.P., Bitner,R.S., Bowersox,S.S., Fox,J.A., Valentino,K.L. and Yamashiro,D.H. Patent: 5051403, -US 24-SEP-1991; (1991) [P, NA] |
| Myers,R.A., Zafaralla,G.C., Gray,W.R., Abbott,J., Cruz,L.J. and Olivera,B.M. alpha-Conotoxins, small peptide probes of nicotinic acetylcholine receptors Biochemistry (1991) 30: 9370-9377 [P, NA] |
| Ott,K.H., Becker,S., Gordon,R.D. and Ruterjans,H. Solution structure of mu-conotoxin GIIIA analysed by 2D-NMR and distance geometry calculations FEBS Lett. (1991) 278: 160-166 [P, NA] |
1990 Haack,J.A., Rivier,J., Parks,T.N., Mena,E.E., Cruz,L.J. and Olivera,B.M. Conantokin-T. A gamma-carboxyglutamate containing peptide with N-methyl-d-aspartate antagonist activity J. Biol. Chem. (1990) 265: 6025-6029 [P, NA] |
| Hidaka,Y., Sato,K., Nakamura,H., Kobayashi,J., Ohizumi,Y. and Shimonishi,Y. Disulfide pairings in geographutoxin I, a peptide neurotoxin from Conus geographus FEBS Lett. (1990) 264: 29-32 [P, NA] |
| Olivera,B.M., Rivier,J., Clark,C., Ramilo,C.A., Corpuz,G.P., Abogadie,F.C., Mena,E.E., Woodward,S.R., Hillyard,D.R. and Cruz,L.J. Diversity of Conus neuropeptides Science (1990) 249: 257-263 [P, NA] |
| Woodward,S.R., Cruz,L.J., Olivera,B.M. and Hillyard,D.R. Constant and hypervariable regions in conotoxin propeptides EMBO J. (1990) 9: 1015-1020 [P, NA] |
1989 Hillyard,D.R., Olivera,B.M., Woodward,S., Corpuz,G.P., Gray,W.R., Ramilo,C.A. and Cruz,L.J. A molluscivorous Conus toxin: conserved frameworks in conotoxins Biochemistry (1989) 28: 358-361 [P, NA] |
| Kobayashi,Y., Ohkubo,T., Kyogoku,Y., Nishiuchi,Y., Sakakibara,S., Braun,W. and Go,N. Solution conformation of conotoxin GI determined by 1H nuclear magnetic resonance spectroscopy and distance geometry calculations Biochemistry (1989) 28: 4853-4860 [P, NA] |
| Pardi,A., Galdes,A., Florance,J. and Maniconte,D. Solution structures of alpha-conotoxin G1 determined by two-dimensional NMR spectroscopy Biochemistry (1989) 28: 5494-5501 [P, NA] |
| Yoshikami,D. and Olivera,B.M. The inhibitory effects of omega-conotoxins on Ca channels and synapses. Ann. N. Y. Acad. Sci. (1989) 560: 230-248 [P, NA] |
1988 Gray,W.R., Olivera,B.M. and Cruz,L.J. Peptide toxins from venomous Conus snails Annu. Rev. Biochem. (1988) 57: 665-0 [P, NA] |
| Yanagawa,Y., Abe,T., Satake,M., Odani,S., Suzuki,J. and Ishikawa,K. A novel sodium channel inhibitor from Conus geographus: purification, structure, and pharmacological properties Biochemistry (1988) 27: 6256-6262 [P, NA] |
| Zafaralla,G.C., Ramilo,C., Gray,W.R., Karlstrom,R., Olivera,B.M. and Cruz,L.J. Phylogenetic specificity of cholinergic ligands: alpha-conotoxin SI Biochemistry (1988) 27: 7102-7105 [P, NA] |
1987 Cruz,L.J., de Santos,V., Zafaralla,G.C., Ramilo,C.A., Zeikus,R., Gray,W.R. and Olivera,B.M. Invertebrate vasopressin/oxytocin homologs. Characterization of peptides from Conus geographus and Conus straitus venoms J. Biol. Chem. (1987) 262: 15821-15824 [P, NA] |
| Olivera,B.M., Cruz,L.J., de Santos,V., Lecheminant,G.W., Griffin,D., Zeikus,R.D., McIntosh,J.M., Galyean,R., Varga,J., Gray,W.R. and Rivier,J.E. Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using omega-conotoxin from Conus magus venom Biochemistry (1987) 26: 2086-2090 [P, NA] |
| Rivier,J., Galyean,R., Gray,W.R., Azimi-Zonooz,A., McIntosh,J.M., Cruz,L.J. and Olivera,B.M. Neuronal calcium channel inhibitors. Synthesis of omega-conotoxin GVIA and effects on 45Ca uptake by synaptosomes J. Biol. Chem. (1987) 262: 1194-1198 [P, NA] |
1986 Nishiuchi,Y., Kumagaye,K., Noda,Y., Watanabe,T.X. and Sakakibara,S. Synthesis and secondary-structure determination of omega-conotoxin GVIA: a 27-peptide with three intramolecular disulfide bonds Biopolymers (1986) 25 Suppl [P, NA] |
| Ramilo,C.A. Thesis (1986) [P, NA] |
1985 Cruz,L.J., Gray,W.R., Olivera,B.M., Zeikus,R.D., Kerr,L., Yoshikami,D. and Moczydlowski,E. Conus geographus toxins that discriminate between neuronal and muscle sodium channels J. Biol. Chem. (1985) 260: 9280-9288 [P, NA] |
| Olivera BM, McIntosh JM, Clark C, Middlemas D, Gray WR, Cruz LJ. A sleep-inducing peptide from Conus geographus venom. Toxicon (1985) 23: 277-282 [P, NA] |
| Olivera,B.M., Gray,W.R., Zeikus,R., McIntosh,J.M., Varga,J., Rivier,J., de Santos,V. and Cruz,L.J. Peptide neurotoxins from fish-hunting cone snails Science (1985) 230: 1338-1343 [P, NA] |
1984 Gray,W.R., Luque,F.A., Galyean,R., Atherton,E., Sheppard,R.C., Stone,B.L., Reyes,A., Alford,J., McIntosh,M., Olivera,B.M., Cruz,L.J. and Rivier,J. Conotoxin GI: disulfide bridges, synthesis, and preparation of iodinated derivatives Biochemistry (1984) 23: 2796-2802 [P, NA] |
| Kerr,L.M. and Yoshikami,D. A venom peptide with a novel presynaptic blocking action. Nature (1984) 308: 282-284 [P, NA] |
| McIntosh,J.M., Olivera,B.M., Cruz,L.J. and Gray,W.R. Gamma-carboxyglutamate in a neuroactive toxin J. Biol. Chem. (1984) 259: 14343-14346 [P, NA] |
| Olivera,B.M., McIntosh,J.M., Cruz,L.J., Luque,F.A. and Gray,W.R. Purification and sequence of a presynaptic peptide toxin from Conus geographus venom Biochemistry (1984) 23: 5087-5090 [P, NA] |
1983 Gray,W.R., Rivier,J.E., Galyean,R., Cruz,L.J. and Olivera,B.M. Conotoxin MI. Disulfide bonding and conformational states J. Biol. Chem. (1983) 258: 12247-12251 [P, NA] |
| Sato,S., Nakamura,H., Ohizumi,Y., Kobayashi,J. and Hirata,Y. The amino acid sequences of homologous hydroxyproline-containing myotoxins from the marine snail Conus geographus venom FEBS Lett. (1983) 155: 277-280 [P, NA] |
1982 McIntosh,M., Cruz,L.J., Hunkapiller,M.W., Gray,W.R. and Olivera,B.M. Isolation and structure of a peptide toxin from the marine snail Conus magus Arch. Biochem. Biophys. (1982) 218: 329-334 [P, NA] |
| Nishiuchi,Y. and Sakakibara,S. Primary and secondary structure of conotoxin GI, a neurotoxic tridecapeptide from a marine snail FEBS Lett. (1982) 148: 260-262 [P, NA] |
1981 Gray,W.R., Luque,A., Olivera,B.M., Barrett,J. and Cruz,L.J. Peptide toxins from Conus geographus venom J. Biol. Chem. (1981) 256: 4734-4740 [P, NA] |
1976 Tarshis,M.A., Bekkouzjin,A.G. and Panchenko,L.F. Properties of the 3-o-methyl-D-glucose transport system in Acholeplasma laidlawii. J. Bacteriol. (1976) 125: 1-7 [P, NA] |
| Duda,T.F. and Palumbi,S.R. Molecular evolution of four-loop conotoxin precursors from fish-eating Conus (Unpublished) [P, NA] |
| Duda,T.F. Jr. Positive selection and patterns of divergence of orthologous toxin genes among related venomous predatory gastropods (Unpublished) [P, NA] |
| Duda,T.F. Jr. and Palumbi,S.R. Convergent evolution of venoms and feeding ecologies among polyphyletic piscivorous Conus species (Unpublished) [P, NA] |
No Year Liu, L., Chi, C.W. and Wang, C.G. cDNA of S-superfamily conotoxin precursor from Conus caracteristicus Unpublished (0) [P, NA] |
| Lu,B.S., Yu,F., Wang,J.H., Zhao,D., Zhao,S.Q. and Huang,P.T. Cloning of alpha-conotoxin sequences from Conus textile venom duct (Unpublished) [P, NA] |
| Luo,S. and Zhangsun,D. Hainan O-superfamily peptides (Unpublished) [P, NA] |
| Luo,S., Zhang,B. and Zhangsun,D. C11GB conotoxin scaffold VI/VII precursor (Unpublished) [P, NA] |
| Luo,S., Zhang,B. and Zhangsun,D. A11GB conotoxin scaffold VI/VII precursor (Unpublished) [P, NA] |
| Luo,S., Zhangsun,D. and Zhang,B. Hainan O-superfamily peptides (Unpublished) [P, NA] |
| Luo,S., Zhangsun,D., Zhang,B. and Lin,Q. Hainan O-superfamily peptides (Unpublished) [P, NA] |
| Luo,S., Zhangsun,D., Zhang,B. and Lin,Q. Novel O-superfamily conotoxins, and their coding polynucleotides and use (Unpublished) [P, NA] |
| Peng, C., Wu, X., Han, Y., Yuan, D., Chi, C. and Wang, C. Identification of six novel T-1 conotoxins from the venom ducts of Conus pulicarius by molecular cloning Unpublished (0) [P, NA] |
| Peng, C., Wu, X., Wang, Y., Shao, X., Chi, C. and Wang, C. Identification and characterization of a new four-Cys conotoxin (framework 14) from the vermivorous Conus pulicarius, pu14a, a novel antagonist of nicotinic acetylcholine receptors Unpublished (0) [P, NA] |
| Walker,C., Shetty,R., Olivera,B.M., Hooper,D., Jacobsen,R., Steele,D. and Jones,R.M. Tau-conotoxin peptides (Unpublished) [P, NA] |
| Yuan, D., Liu, L., Chi, C. and Guo, Z. New conotoxins define a novel I3-superfamily Unpublished (0) [P, NA] |
| Zhao,D. and Huang,P. Conus imperialis conotoxin ImIIA precursor mRNA (Unpublished) [P, NA] |
Favreau,P. Physico-chemical and pharmacological study of new toxins from the piscivorous cone snail Conus consors Thesis (1999) () [P, NA] |
Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6
ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.
The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).
Contacts:
David Craik
Quentin Kaas
Last updated: Saturday 30 September 2023