Gene superfamily | # protein precursors | # nucleic sequences | Cysteine frameworks | Pharmacological family | # species | Clades | Diet | Geographic location |
---|---|---|---|---|---|---|---|---|
A superfamily | 347 | 354 | I,II,IV,VI/VII,XIV,XXII | α,κ,ρ | 56 | Early,I,II,III,V,VI,VII,IX,X,XI,XII,XIII,XIV,XV,XVII | G,M,P,V | EA,EP,IP,WA |
B1 superfamily | 66 | 7 | 16 | I,II,III,VII,IX,XIV | G,P,V | EA,EP,IP,WA | ||
B2 superfamily | 25 | VIII | 4 | I,II,VI,XII | M,P,V | IP | ||
B3 superfamily | 1 | 1 | XXIV | 1 | XII | V | IP | |
C superfamily | 8 | 9 | 5 | I,II,IV,XII | P,V | IP | ||
D superfamily | 122 | 18 | IV,XIV,XV,XX,XXIV,XXVIII | α | 13 | I,III,IX,XII,XIV,XVII | P,V | EA,EP,IP,WA |
E superfamily | 9 | 3 | XXII | 6 | I,III,VI,VII,XVII | M,P,V | EA,IP,WA | |
F superfamily | 18 | 3 | 6 | I,V,VI,XII | M,P,V | IP | ||
G superfamily | 1 | 1 | XIII | 1 | V | WA | ||
H superfamily | 21 | 5 | VI/VII | 6 | I,II,V,VI | M,P,V | IP | |
I1 superfamily | 33 | 22 | VI/VII,XI,XXII | ι | 22 | Early,I,V,VI,IX,X,XIV,XVII | M,P,V | EP,IP |
I2 superfamily | 85 | 49 | VI/VII,XI,XII,XIII,XIV | κ | 24 | I,V,VI,VII,IX,X,XII,XIII,XIV,XVII | G,M,P,V | IP,WA |
I3 superfamily | 16 | 11 | VI/VII,XI | 9 | Early,II,IX,X,XII,XIV | P,V | IP | |
J superfamily | 47 | 27 | XIV | κ | 16 | I,II,V,VI,IX,X,XII,XIII,XIV,XVII | G,M,P,V | IP |
K superfamily | 6 | 4 | XXIII | 3 | I,VII,XVII | P,V | IP | |
L superfamily | 28 | 11 | XIV,XXIV | α | 11 | Early,I,II,VII,IX,XII,XIV | G,P,V | EP,IP |
M superfamily | 650 | 574 | I,II,III,IV,VI/VII,IX,XIV,XVI,XXXII | α,ι,κ,μ | 54 | Early,I,II,III,IV,V,VI,VII,IX,X,XI,XII,XIII,XIV,XVI,XVII | G,M,P,V | EA,EP,IP |
N superfamily | 5 | 1 | XV | 4 | I,VI,X,XVII | M,P,V | IP | |
O1 superfamily | 709 | 689 | I,VI/VII,IX,XII,XIV,XVI,XXIX | δ,γ,κ,μ,ω | 66 | Early,I,II,III,V,VI,VII,IX,X,XI,XII,XIII,XIV,XV,XVI,XVII | G,M,P,V | EA,EP,IP,WA |
O2 superfamily | 192 | 136 | I,VI/VII,XII,XIV,XV,XVI | γ | 40 | Early,I,II,III,V,VI,VII,IX,X,XI,XII,XIII,XIV,XVI,XVII | M,P,V | EA,EP,IP |
O3 superfamily | 61 | 38 | VI/VII,XVI | 21 | Early,I,II,V,VII,IX,XIII,XIV,XVI | G,M,P,V | EA,IP | |
P superfamily | 22 | 15 | IX,XIV | 11 | I,V,X,XIV,XVII | M,P,V | EP,IP | |
Q superfamily | 23 | 22 | VI/VII,XVI | 5 | VII,X,XIV | V | IP | |
R superfamily | 8 | XIV | 2 | V | WA | |||
S superfamily | 33 | 14 | VIII,XXXIII | α,σ | 15 | Early,I,II,V,VI,X,XIV,XVII | M,P,V | IP |
T superfamily | 280 | 235 | I,V,X,XVI | χ,ε,μ | 39 | Early,I,II,III,V,VI,VII,IX,X,XI,XII,XIII,XIV,XVI,XVII | G,M,P,V | EA,EP,IP,WA |
U superfamily | 9 | 3 | VI/VII | 4 | V | M,V | IP | |
V superfamily | 2 | 2 | XV | 2 | XIII | V | IP | |
Y superfamily | 4 | 1 | VI/VII,XVII | 4 | I,VII,XIV | P,V | IP | |
conodipine superfamily | 5 | 5 | 1 | III | P | EP |
Framework | # mature proteins | Gene superfamilies | Pharmacological family | # species | Clades | Diet | Geographic location |
---|---|---|---|---|---|---|---|
I | 448 | A,M,O1,O2,T | α,ρ | 77 | Early,I,II,III,V,VI,VII,IX,X,XI,XII,XIII,XIV,XV,XVII | G,M,P,V | EA,EP,IP,SA,WA |
II | 7 | A,M | α | 4 | I,XII | P,V | IP |
III | 517 | M | α,ι,κ,μ | 54 | I,II,III,IV,V,VI,VII,IX,X,XI,XII,XIII,XIV,XVI,XVII | G,M,P,V | EA,EP,IP,SA |
IV | 105 | A,D,M | α,κ,μ | 23 | I,II,III,V,X,XII,XIV | M,P,V | EA,EP,IP,WA |
V | 259 | T | ε,μ | 44 | Early,I,II,III,V,VI,VII,IX,X,XI,XII,XIII,XIV,XVI,XVII | G,M,P,V | EA,EP,IP,WA |
VI/VII | 935 | A,H,I1,I2,I3,M,O1,O2,O3,Q,U,Y | δ,γ,κ,μ,ω | 75 | Early,I,II,III,IV,V,VI,VII,IX,X,XI,XII,XIII,XIV,XV,XVI,XVII | G,M,P,V | EA,EP,IP,SA,WA |
VIII | 51 | B2,S | α,σ | 21 | Early,I,II,V,VI,VII,IX,X,XII,XIV,XVII | M,P,V | EP,IP |
IX | 68 | M,O1,P | 21 | Early,I,II,V,VII,IX,X,XII,XIV,XVII | G,M,P,V | EP,IP | |
X | 10 | T | χ | 4 | V,VI | M | IP |
XI | 134 | I1,I2,I3 | ι,κ | 35 | Early,I,II,V,VI,VII,IX,X,XII,XIII,XIV,XVII | G,M,P,V | EP,IP,WA |
XII | 64 | I2,O1,O2 | 13 | Early,I,V,VI,VII,IX,XIII,XIV,XVII | G,M,P,V | EP,IP | |
XIII | 4 | G,I2 | 3 | XII | V | IP,WA | |
XIV | 136 | A,D,I2,J,L,M,O1,O2,P,R | α,κ | 30 | Early,I,II,V,VI,VII,IX,X,XII,XIII,XIV,XVI,XVII | G,M,P,V | EP,IP,WA |
XV | 46 | D,N,O2,V | 23 | Early,I,II,V,VI,VII,IX,X,XII,XIII,XIV | M,P,V | IP | |
XVI | 22 | M,O1,O2,O3,Q,T | 15 | Early,I,II,V,VII,IX,XIV,XVII | M,P,V | EP,IP,SA | |
XVII | 4 | Y | 3 | VII,XIV | V | IP | |
XVIII | 2 | 2 | I,X | P,V | IP | ||
XIX | 3 | 3 | Early,IX,XIV | V | IP | ||
XX | 48 | D | α | 12 | III,IX,XII,XIV,XVII | P,V | EA,EP,IP,WA |
XXI | 7 | 5 | II,III,V,IX,XII | M,P,V | EP,IP | ||
XXII | 47 | A,E,I1 | 12 | Early,I,II,III,V,VI,VII,XII,XVII | M,P,V | EA,EP,IP,WA | |
XXIII | 9 | K | 5 | I,VI,VII,XIII,XVII | M,P,V | IP | |
XXIV | 6 | B3,D,L | 2 | XII | V | IP | |
XXV | 1 | 1 | V | WA | |||
XXVI | 1 | 1 | V | EP | |||
XXVII | 19 | 11 | Early,I,IX,XI,XII | P,V | EP,IP | ||
XXVIII | 8 | D | 3 | I,XVII | P,V | IP | |
XXIX | 2 | O1 | 1 | Early | P | EP | |
XXX | 1 | 1 | Early | P | EP | ||
XXXII | 4 | M | 4 | VII | V | IP | |
XXXIII | 2 | S | 1 | I | P | IP |
Pharmacological family | # mature proteins | Gene superfamilies | Cysteine frameworks | # species | Clades | Diet | Geographic location |
---|---|---|---|---|---|---|---|
alpha conotoxin | 113 | A,B3,C,D,J,L,M,O1,S | I,II,III,IV,V,VIII,XIV,XX,XXIV | 46 | I,II,III,IV,V,VI,VII,IX,X,XII,XIII,XIV,XVII | M,P,V | EA,EP,IP,SA,WA |
chi conotoxin | 5 | T | X | 2 | V,VI | M | IP |
delta conotoxin | 23 | O1 | VI/VII,XXXII | 17 | I,III,V,XVI | G,M,P,V | EA,EP,IP,WA |
epsilon conotoxin | 1 | T | V | 1 | V | M | IP |
gamma conotoxin | 5 | O1,O2 | VI/VII | 5 | V | M,V | EP,IP,WA |
iota conotoxin | 2 | I1,M | III,XI | 2 | P,V | IP | |
kappa conotoxin | 12 | A,I2,J,M,O1 | III,IV,VI/VII,XI,XIV,XXXII | 8 | I,III,IX,X,XIII | P,V | EP,IP |
mu conotoxin | 31 | M,O1,T | III,IV,V,VI/VII | 17 | I,II,III,V,VI,X,XVI | M,P,V | EP,IP |
omega conotoxin | 34 | A,O1,O2 | I,VI/VII,IX,XVI,XXVI | 18 | Early,I,II,V,VI,X | G,M,P,V | EP,IP |
rho conotoxin | 2 | A | I,V | 2 | II | P | IP |
sigma conotoxin | 2 | S | VIII | 2 | II,X | P,V | IP |
tau conotoxin | 2 | T | V | 2 | I,VII | P,V | IP |
ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.
The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).
Contacts:
David Craik
Quentin Kaas
Last updated: Tuesday 5 December 2023